Metabolic compartmentalization via glycogenolysis-derived G1P bolsters T cell memory [0.03%]
通过糖原分解衍生的G1P代谢隔室化增强T细胞记忆
Hao Shi,Hongbo Chi
Hao Shi
In this issue of Molecular Cell, Zhou et al.1 show that glycogenolysis-derived glucose-1-phosphate enhances glucose-6-phosphate dehydrogenase oligomerization and activity, promoting the formation of a liquid-liquid phase separation compartm...
Brittney D Bobowski,Yael David
Brittney D Bobowski
In this issue of Molecular Cell, Ingham et al.1 and Matthews et al.2 report CRAMP1 as a key regulator of linker histone transcription in human cells. Cop...
Regulation of somatic hypermutation by higher-order chromatin structure [0.03%]
染色质高级结构对体细胞高突变率的调控作用
Ursula E Schoeberl,Johanna Fitz,Maximilian von der Linde et al.
Ursula E Schoeberl et al.
The generation of protective antibodies by somatic hypermutation (SHM) is essential for antibody maturation and adaptive immunity. SHM involves co-transcriptional mutagenesis of immunoglobulin variable (V) regions regulated by enhancers loc...
Fabian Schildhauer,Petra S J Ryl,Simon M Lauer et al.
Fabian Schildhauer et al.
ATP fuels crucial cellular processes and is obtained mostly by oxidative phosphorylation (OXPHOS) at the inner mitochondrial membrane. While significant progress has been made in mechanistic understanding of ATP production, critical aspects...
Robin Alexander Rothemann,Egor Pavlenko,Mrityunjoy Mondal et al.
Robin Alexander Rothemann et al.
Apoptosis-inducing factor 1 (AIFM1) is a flavoprotein essential for mitochondrial function and biogenesis. Its interaction with MIA40/CHCHD4, the central component of the mitochondrial disulfide relay, accounts for some, but not all, aspect...
The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks [0.03%]
DNA复制检查点限制Okazaki片段积累以保护和重启停滞的叉结构体
Berta Canal,Agostina P Bertolin,Giselle C Lee et al.
Berta Canal et al.
Understanding how DNA replication forks stall and restart and how the DNA replication checkpoint prevents irreversible fork collapse in molecular detail are crucial for understanding how cells maintain stable genomes and how they prevent th...
The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells [0.03%]
DNA复制检查点通过防止PCNA/RFC耗竭来保护人类细胞中的叉子免受HLTF诱导的塌陷
Agostina P Bertolin,Berta Canal,Mona Yekezare et al.
Agostina P Bertolin et al.
The DNA replication checkpoint is crucial for maintaining genome stability after genotoxic stress; without it, stalled DNA replication forks cannot restart normally, excess DNA replication origins are activated, DNA damage and single-strand...
Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation [0.03%]
micro蛋白SMIM26通过丝裂原反应性线粒体翻译驱动氧化代谢
Jiemin Nah,Sreya Mahendran,Baptiste Kerouanton et al.
Jiemin Nah et al.
Mitochondrial small open reading frame (ORF)-encoded microproteins (SEPs) are key regulators and components of the electron transport chain (ETC). Although ETC complex I assembly is tightly coupled to nutrient availability, including serine...
Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer [0.03%]
前列腺癌中NSD3异构体在DNA复制压力下的特异性功能可使肿瘤获得对PARP抑制剂的耐药性
Shouhai Zhu,Huanyao Gao,Dan Jiang et al.
Shouhai Zhu et al.
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients with deleterious BRCA1/2 alterations. Although this marks a significant miles...
BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival [0.03%]
低精氨酸水平感应蛋白BAG2通过释放SAMD4B促进肿瘤细胞存活
Meng-Ying Chen,Chun-Yu Sun,Ru Zhao et al.
Meng-Ying Chen et al.
Cells possess numerous metabolite sensors that detect essential nutrients for growth, with many directly binding to metabolites and responding to their levels. Given the vital role of arginine in various physiological and pathological proce...