Improving the clinical meaning of surrogate endpoints: An empirical assessment of clinical progression in phase III oncology trials [0.03%]
改善替代终点的临床意义III期肿瘤试验中疾病进展的实证评估
Alexander D Sherry,Timothy A Lin,Zachary R McCaw et al.
Alexander D Sherry et al.
Disease progression in clinical trials is commonly defined by radiologic measures. However, clinical progression may be more meaningful to patients, may occur even when radiologic criteria for progression are not met, and often requires a c...
Overall survival and cause-specific mortality in a hospital-based cohort of retinoblastoma patients in São Paulo, Brazil [0.03%]
巴西圣保罗医院视网膜母细胞瘤患者的总生存率和特殊原因死亡率
Karina B Ribeiro,Lene H S Veiga,Nevicolino P Carvalho Filho et al.
Karina B Ribeiro et al.
Studies are lacking on long-term effects among retinoblastoma patients in low- and middle-income countries. Therefore, we examined cause-specific mortality in a retrospective cohort of retinoblastoma patients treated at Antonio Candido de C...
S100a8/a9 regulated by LPS/TLR4 axis plays an important role in Salmonella-based tumor therapy and host defense [0.03%]
LPS/TLR4轴调节的S100A8/A9在沙门菌肿瘤治疗和宿主防御中起重要作用
Yanxia Guo,Yujie Sun,Zhongying Li et al.
Yanxia Guo et al.
Bacteria are ideal anticancer agents and carriers due to their unique capabilities that are convenient in genetic manipulation, tumor-specific targeting, and deep-tissue penetration. However, the specific molecular mechanisms of bacteria-me...
Genomic alterations associated with resistance and circulating tumor DNA dynamics for early detection of progression on CDK4/6 inhibitor in advanced breast cancer [0.03%]
CDK4/6抑制剂治疗转移性乳腺癌的耐药基因组改变及循环肿瘤DNA动态变化用于进展早期检测的研究
Charlotte K Kindt,Carla L Alves,Sidse Ehmsen et al.
Charlotte K Kindt et al.
Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improves outcome for patients with estrogen receptor-positive (ER+) metastatic breast cancer, but drug resistance and thus disease progression inevitably occur. Herein,...
Cancer risk among people living with Human Immunodeficiency Virus (HIV) in Rwanda from 2007 to 2018 [0.03%]
2007年至2018年卢旺达艾滋病毒(HIV)感染者癌症发病风险研究
Jean Claude Dusingize,Gad Murenzi,Benjamin Muhoza et al.
Jean Claude Dusingize et al.
Assessing the risk of cancer among people living with HIV (PLHIV) in the current era of antiretroviral therapy (ART) is crucial, given their increased susceptibility to many types of cancer and prolonged survival due to ART exposure. Our st...
Benefit of adjuvant chemotherapy on recurrence free survival per consensus molecular subtype in stage III colon cancer [0.03%]
III期结肠癌患者不同共识分子分型下辅助化疗对无复发生存的效益分析
Simone van de Weerd,Arezo Torang,Inge van den Berg et al.
Simone van de Weerd et al.
The consensus molecular subtype (CMS) classification divides colon tumors into four subtypes holding promise as a predictive biomarker. However, the effect of adjuvant chemotherapy on recurrence free survival (RFS) per CMS in stage III pati...
Approaches for Lynch syndrome screening and characteristics of subtypes with mismatch repair deficiency in patients with colorectal carcinoma [0.03%]
遗传性非息肉病性大肠癌筛查方法及错配修复缺陷亚型的临床病理特征研究
Xu Feng,Qianlan Yao,Yuyin Xu et al.
Xu Feng et al.
To evaluate different Lynch syndrome (LS) screening approaches and establish an efficient and sensitive strategy are critical for clinical practice. In total, 583 patients with colorectal carcinoma (CRC) at Fudan University Shanghai Cancer ...
One-carbon metabolism biomarkers and upper gastrointestinal cancer in the Golestan Cohort Study [0.03%]
戈勒斯坦队列研究中的一碳代谢生物标志物和上消化道癌症风险关系
Maki Inoue-Choi,Neal D Freedman,Arash Etemadi et al.
Maki Inoue-Choi et al.
Incidence of esophageal and gastric cancer has been linked to low B-vitamin status. We conducted matched nested case-control studies of incident esophageal squamous cell carcinoma (ESCC; 340 case-control pairs) and gastric cancer (GC; 352 c...
The current therapeutic cancer vaccines landscape in non-small cell lung cancer [0.03%]
当前非小细胞肺癌治疗性癌症疫苗格局
Shaoyi Chen,Sida Cheng,Jingsheng Cai et al.
Shaoyi Chen et al.
Currently, conventional immunotherapies for the treatment of non-small cell lung cancer (NSCLC) have low response rates and benefit only a minority of patients, particularly those with advanced disease, so novel therapeutic strategies are u...
Genomic mutation patterns and prognostic value in de novo and secondary acute myeloid leukemia: A multicenter study from China [0.03%]
中国多中心急性髓系白血病的基因组突变模式及预后价值：初次发病与继发病例的区别
Xi Dou,Chunli Dan,Duanzhong Zhang et al.
Xi Dou et al.
Acute myeloid leukemia (AML) can manifest as de novo AML (dn-AML) or secondary AML (s-AML), with s-AML being associated with inferior survival and distinct genomic characteristics. The underlying reasons for this disparity remain to be eluc...
Multicenter Study
International journal of cancer. 2024 Dec 15;155(12):2253-2264. DOI:10.1002/ijc.35125 2024