Optimizing management of stage IV EGFR mutant non-small cell lung cancer in Asia: An expert opinion [0.03%]
亚洲晚期EGFR突变型非小细胞肺癌的治疗优化——专家意见
Gee-Chen Chang,Akhil Kapoor,Chee Khoon Lee et al.
Gee-Chen Chang et al.
Lung cancer is Asia's most prevalent cancer, accounting for the highest global patient share. A significant number of non-small cell lung cancer (NSCLC) patients in Asia exhibit mutations in the epidermal growth factor receptor (EGFR). Alth...
Serum 25-hydroxyvitamin D, vitamin D-related variants, and risk of chronic liver disease [0.03%]
血清25-羟基维生素D、维生素D相关变异和慢性肝病风险的关系
Qian Shen,Shanshan Shi,Haoxue Wang et al.
Qian Shen et al.
The associations of serum 25-hydroxyvitamin D (25(OH)D) with cirrhosis and liver cancer have not been well examined. It remained unclear whether functional vitamin D-related variants modify these associations. During follow-up of 401,551 UK...
Generation and functional analysis of melanoma antigen-specific CD8+ T cells derived from S/MAR vector-transfected human induced pluripotent stem cells [0.03%]
由S/MAR载体转染的人诱导多能干细胞衍生的黑色素瘤抗原特异性CD8+t细胞的生成及功能分析
Juliane Poelchen,Sandra Pardo,Daniel Novak et al.
Juliane Poelchen et al.
Melanoma accounts for the majority of all skin cancer-related deaths with rising incidence rates. Adoptive cell therapies (ACT) with tumor antigen-specific CD8+ T cells derived from human-induced pluripotent stem cells (hiPSCs) might offer ...
Deciphering dual clinical entities associated with TP53 pathogenic variants: Insights from 53,085 HBOC panel analyses in French laboratories [0.03%]
TP53致病性变异相关双重临床实体的解析——来自法国实验室53085例遗传性癌症综合征基因panel检测的启示
Edwige Kasper,Flavie Boulouard,Noémie Basset et al.
Edwige Kasper et al.
TP53 is included in most cancer predisposition multigene panels, especially those exploring Hereditary Breast and Ovarian Cancer (HBOC) predisposition. The purpose of this study was to define the contribution of TP53 pathogenic variants (PV...
Tracking cancer-related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients [0.03%]
化疗期间追踪癌症相关性疲劳：一项早期乳腺癌患者队列比较研究的见解
Joris Mallard,Elyse Hucteau,Roland Schott et al.
Joris Mallard et al.
Cancer-related fatigue (CRF) is a multifactorial symptom commonly experienced by breast cancer patients treated with chemotherapy (CT) that impairs quality of life and may influence cancer recurrence by reducing treatment compliance. This c...
DNA methylation biomarkers for cervical cancer risk prediction in HIV-positive Nigerian women [0.03%]
用于预测尼日利亚HIV阳性女性宫颈癌风险的DNA甲基化生物标志物
Yinan Zheng,Jingzhe Han,Yishu Qu et al.
Yinan Zheng et al.
Cervical cancer (CC) remains a significant public health issue in low- and middle-income countries (LMICs), especially in Western sub-Saharan Africa and Nigeria. While global CC incidence and mortality have declined, these regions continue ...
Future of population-based cancer registries: A global perspective-A survey of population-based cancer registries [0.03%]
人口为基础的癌症登记处的未来——全球视角：一项基于人口的癌症登记调查研究
Liesbet J Van Eycken,Eleni Giannopoulos,Zuzanna Tittenbrun et al.
Liesbet J Van Eycken et al.
Population-Based Cancer Registries (PBCRs) play a fundamental role in cancer control. They collect data to compile information on the occurrence, extent, and outcome of cancer in geographically defined populations. Whilst the basic reportin...
The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes [0.03%]
儿童不同类型的急性淋巴细胞白血病中环境相关DNA甲基化的潜在作用
Jessica R Saville,Lisa J Russell,Kay Padget et al.
Jessica R Saville et al.
Various genetic aberrations are suggested to initiate the development of acute lymphoblastic leukaemia (ALL) but alone are insufficient for disease onset. Epigenetic alteration, such as DNA methylation changes, plays a key role in human hea...