Optimal therapeutic strategies for hepatic metachronous oligometastatic nasopharyngeal carcinoma: Insights from a retrospective study [0.03%]
晚发寡转移性鼻咽癌肝转移的治疗策略选择：一项回顾性研究的启示
Haoyang Huang,Yuping Zhao,Ying Deng et al.
Haoyang Huang et al.
Hepatic metachronous oligometastatic nasopharyngeal carcinoma (hmoNPC) exhibits distinct clinical characteristics compared to other types of metastatic NPC. We investigated the optimal therapy for hmoNPC. 160 patients with hmoNPC treated in...
Adherence to melanoma screening and surveillance skin check schedules tailored to personal risk [0.03%]
遵循针对个人风险量身定制的黑色素瘤筛查和监测皮肤检查时间表
Methmi M Perera,Amelia K Smit,Andrea L Smith et al.
Methmi M Perera et al.
Population-wide skin cancer screening is not currently recommended in most countries. Instead, most clinical guidelines incorporate risk-based recommendations for skin checks, despite limited evidence around implementation and adherence to ...
Optimizing treatment sequence for inoperable locally advanced breast cancer: Long-term outcomes of surgery first versus neoadjuvant chemotherapy in a real-world setting [0.03%]
不可手术的局部晚期乳腺癌的最佳治疗顺序：真实世界环境下外科手术优先和新辅助化疗长期结果的对比研究
Bowen Liu,Yu Song,Ying Xu et al.
Bowen Liu et al.
Locally advanced breast cancer (LABC) is challenging with limited treatment options. This study investigates the feasibility and long-term outcomes of upfront surgery compared to neoadjuvant chemotherapy (NAC) in a real-world cohort. This r...
Comparative Study
International journal of cancer. 2025 Jan 15;156(2):368-378. DOI:10.1002/ijc.35140 2025
Does ambient particulate matter 1 increase the risk of gastric cancer in the northwest of China? [0.03%]
中国西北地区环境颗粒物(PM₁)与胃癌发病风险关系的队列研究
Jie Liu,Ting Gan,Wenbiao Hu et al.
Jie Liu et al.
Gastric cancer (GC) remains a significant health concern in Gansu province, China, with morbidity and mortality rates surpassing national averages. Despite the recognized health risks associated with ambient particulate matter with an aerod...
Tripokin: A multi-specific immunocytokine for cancer immunotherapy [0.03%]
用于癌症免疫治疗的多特异免疫细胞因子Trapokin
Eleonora Prodi,Riccardo Corbellari,Lorenzo Ghezzi et al.
Eleonora Prodi et al.
Antibodies that target the tumor microenvironment can be used to deliver pro-inflammatory payloads, such as cytokines. Cytokines are small proteins able to modulate the activity of the immune system, and antibody-cytokine fusion proteins ha...
B cells critical for outcome in high grade serous ovarian carcinoma [0.03%]
高级别浆液性卵巢癌中B细胞对预后的影响关键性研究
Annegé Vledder,Sterre T Paijens,Dominik Loiero et al.
Annegé Vledder et al.
Recent work has shown evidence for the prognostic significance of tumor infiltrating B cells (B-TIL) in high grade serous ovarian carcinoma (HGSOC), the predominant histological subtype of ovarian cancer. However, it remains unknown how the...
Prolonged inhibition of intratumoral mast cells enhances efficacy of low-dose antiangiogenic therapy [0.03%]
长效抑制瘤内肥大细胞可增强低剂量抗血管生成药物的疗效
Nikolaus Berenbrok,Maria Elena Vargas-Delgado,Antonia Beitzen-Heineke et al.
Nikolaus Berenbrok et al.
Low-dose antiangiogenic therapies have demonstrated the ability to enhance normalization of tumor vessels, consequently improving hypoxia levels, drug delivery, and promoting anticancer immune responses. Mast cells have been identified as c...
Recurrent cervical cancer detection using DNA methylation markers in self-collected samples from home [0.03%]
基于自我收集样本的宫颈癌复发检测——DNA甲基化标志物分析在家中的应用
Mirte Schaafsma,Rianne van den Helder,Constantijne H Mom et al.
Mirte Schaafsma et al.
Early detection of recurrent cervical cancer is important to improve survival rates. The aim of this study was to explore the clinical performance of DNA methylation markers and high-risk human papillomavirus (HPV) in cervicovaginal self-sa...
Representation of women in clinical trials supporting FDA-approval of contemporary cancer therapies [0.03%]
当代癌症治疗FDA批准临床试验中女性的代表性分析
Sujay Kalathoor,Sanam Ghazi,Beryl Otieno et al.
Sujay Kalathoor et al.
Contemporary anticancer therapies frequently have different efficacy and side effects in men and women. Yet, whether women are well-represented in pivotal trials supporting contemporary anticancer drugs is unknown. Leveraging the Drugs@FDA ...
Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses [0.03%]
胆囊切除与智利消化系统癌症的关联：来自时间序列分析和数据汇总结果的补充证据
Constanza Gonzalez,Alfonso García-Pérez,Bruno Nervi et al.
Constanza Gonzalez et al.
Gallbladder cancer (GBC) mortality in Chile is among the highest worldwide. In 2006, the Chilean government launched a programme guaranteeing access to gallbladder surgery (cholecystectomy) for patients aged 35-49 years. We evaluated the im...