The Predictive Value of the Tumor-Stroma Ratio for Neoadjuvant Endocrine Therapy in Hormone Receptor-Positive Breast Cancer [0.03%]
肿瘤-间质比对激素受体阳性乳腺癌新辅助内分泌治疗疗效预测价值的研究
Layla Andour,Sophie C Hagenaars,Anne Florine de Groot et al.
Layla Andour et al.
Approximately 75% of breast cancers are hormone receptor-positive (HR+). Endocrine therapy may be administered to improve survival. Neoadjuvant therapy may enable breast- and axilla-conserving surgery, but identifying who will benefit remai...
Peri-Operative Detection of Circulating Tumor DNA Using a Customized NGS Tumor-Informed Assay in Patients With HPV-Negative Locally Advanced Head and Neck Squamous Cell Carcinoma [0.03%]
用于人乳头瘤病毒阴性局部晚期头颈部鳞癌患者术前和术后循环肿瘤DNA检测的定制化NGS肿瘤知情检测试验
Ludivine Beaussire-Trouvay,Franchel-Raïs Obongo-Anga,Emilie Lévêque et al.
Ludivine Beaussire-Trouvay et al.
ctDNA is a promising tool to optimize therapeutic strategies in patients treated for locally advanced head and neck cancer that is negative for Human Papilloma Virus (LAHNSCC/HPV-). The objective was to evaluate pre and postoperative detect...
Sphingosine-1-Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis [0.03%]
鞘氨醇-1-磷酸受体1促进卵巢癌肿瘤 sphere增殖和转移
Núria Gendrau-Sanclemente,Agnès Figueras,Ferran Medina-Jover et al.
Núria Gendrau-Sanclemente et al.
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites a...
Effect of Interval Between Neoadjuvant Immunochemotherapy and Radical Resection of Non-Small Cell Lung Cancer: A Multicenter, Retrospective Cohort Study [0.03%]
非小细胞肺癌新辅助免疫化疗与根治性手术间隔时间的的影响：一项多中心回顾性队列研究
Jiayi Wang,Pingping Song,Yong Ge et al.
Jiayi Wang et al.
Radical surgery following neoadjuvant immunochemotherapy (NICT) has emerged as a critical therapeutic strategy in the standardized management of locally advanced non-small cell lung cancer (NSCLC). Robust evidence on the optimal time interv...
Aleksandra Šavrova,Helen Jakoby,Anna Tisler et al.
Aleksandra Šavrova et al.
Effective cervical cancer screening and progress toward WHO elimination targets depend on complete follow-up for women with positive primary screening tests. However, real-world data on this critical step in hrHPV-based screening programs i...
Head-to-head comparison of the diagnostic value of fecal and serum carcinoembryonic antigen for colorectal cancer detection [0.03%]
粪便癌胚抗原与血清癌胚抗原在结直肠癌检测中的诊断价值比较研究
Xianzhe Li,Zitong Zhao,Lara Stassen et al.
Xianzhe Li et al.
This study aimed to conduct a head-to-head comparison of the diagnostic value of serum carcinoembryonic antigen (sCEA) and fecal CEA (fCEA) for colorectal cancer (CRC) detection. Fecal and serum samples from 80 CRC cases at various tumor st...
At what age should people with obesity start colorectal cancer screening? [0.03%]
肥胖人群多大年龄开始进行结直肠癌筛查？
Teresa Seum,Marko Mandic,Fatemeh Safizadeh et al.
Teresa Seum et al.
The incidence of obesity and early-onset colorectal cancer (CRC) has rapidly increased in recent decades. We estimated CRC risk differences by body mass index (BMI) and derived corresponding BMI-specific CRC screening initiation ages across...
Focused Ultrasound-Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri-Focally Localized Glioblastoma Cells [0.03%]
磁定位聚焦超声波机械消融对残存肿瘤及周边 glioblastoma 细胞糖代谢的影响研究
Frieda Bayler,Jonna Holler,Jacqueline Clüver et al.
Frieda Bayler et al.
Glioblastomas (GBMs) are highly aggressive and therapy-resistant brain tumors, mainly driven by stem-like cells and profound metabolic plasticity. Novel treatment strategies, including mechanical high-intensity focused ultrasound (mFUS), ar...
Germline Mutation Landscape of Neuroendocrine Tumors in the Chinese Population [0.03%]
中国人神经内分泌肿瘤种系突变图谱
Yuting Sun,Lin Dong,Huijing Tan et al.
Yuting Sun et al.
Certain hereditary syndromes increase the incidence of neuroendocrine tumors (NETs), suggesting germline variation may play a role in NET pathogenesis. However, the germline mutation spectrum in Chinese NET patients remains unclear. This st...
The 2023 FIGO staging system in uterine serous carcinoma: Exploring prognostic utility and molecular characterization [0.03%]
2023年FIGO子宫浆液性癌分期系统：探讨预后价值和分子特征
Jiang Meng,Li Ge,Xiaoli Wang et al.
Jiang Meng et al.
This study evaluated the prognostic performance of the 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system in Chinese uterine serous carcinoma (USC) patients and defined the disease's molecular landscape. Retros...