HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Measurement of Disease Burden in Oropharyngeal Cancer [0.03%]
人乳头瘤病毒血清学和循环型病毒DNA在口咽癌检测、分型及评估疾病负担中的应用
Lucas Penny,Eric Yang Stutheit-Zhao,Birgitta E Michels et al.
Lucas Penny et al.
The incidence of human papillomavirus-positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly, and HPV early antigen serology has been proposed as a scalable and cost-effective early detection test. HPV seropositivity can precede c...
Asymptomatic Cardiotoxicity After High-Dose Anthracycline Treatment in Sarcoma Patients Assessed by Biomarkers and Echocardiography [0.03%]
生物标志物和超声心动图评估高剂量化疗后肉瘤患者的无症状心毒性
Elissa A S Polomski,Frank M Speetjens,J Wouter Jukema et al.
Elissa A S Polomski et al.
Treatment of sarcoma includes high-dose anthracyclines, which can cause cardiotoxicity. This study assesses the correlation of cardiac biomarkers and echocardiographic parameters on asymptomatic cardiotoxicity in sarcoma patients treated wi...
Triage Performance of FAM19A4/miR124-2 Methylation: 18-Month Follow-Up Results From a Prospective Observational Study Within the Dutch Primary HPV-Based Cervical Screening Program [0.03%]
FAM19A4/miR124-2甲基化 triage检测性能：荷兰一级HPV宫颈筛查项目中的前瞻性观察研究的18个月随访结果
Lisanne Verhoef,Mila S Griffioen,Maaike C G Bleeker et al.
Lisanne Verhoef et al.
DNA methylation analysis of the genes FAM19A4 and miR124-2 has emerged as a promising triage strategy for high-risk (hr) human papillomavirus (HPV)-positive women in cervical screening. This study reports a prospective evaluation of the dia...
Adjuvant Chemotherapy Regimens in Resected Biliary Tract Cancers: National, Comparative, Observational Study (TOG/GI-SAFRADJU-2501) [0.03%]
可切除胆道癌辅助化疗方案：一项国家比较观察性研究（TOG/GI-SAFRADJU-2501）
Erman Akkus,Mehmet Kayaalp,Müzeyyen Aslı Ergözoğlu et al.
Erman Akkus et al.
The recommended adjuvant chemotherapy (adj-ChT) regimen for resected biliary tract cancers (BTC) is capecitabine (Cape); yet, the recommendation is based on limited evidence. Although varied adj-ChTs have been employed in practice, robust r...
Clement Richard Boland,Matthew B Yurgelun
Clement Richard Boland
This reviews the historical evolution of our understanding of the familial gastrointestinal cancer syndromes. It begins centuries ago with the appreciation of the gastrointestinal polyposis syndromes and the relationship between adenomatous...
HPV Testing Versus Cytology for Cervical Cancer Screening Among Women 50 Years and Older: Evidence From the HPV FOCAL Randomized Controlled Trial [0.03%]
人乳头瘤病毒检测与细胞学检查在50岁及以上女性宫颈癌筛查中的比较：人乳头瘤病毒FOCAL随机对照试验的证据
Md Saiful Alam,Laurie W Smith,Lovedeep Gondara et al.
Md Saiful Alam et al.
Evidence on the comparative effectiveness of HPV testing versus cytology specifically in women aged ≥ 50 years who are approaching screening cessation remains limited. This analysis included 6471 women aged ≥ 50 at baseline screening in t...
Reassessing the Incidence and Risk Factors of Radiation Pneumonitis in Treatment-Naive EGFR-Mutant NSCLC With Concurrent Third-Generation EGFR-TKI and Thoracic Radiotherapy [0.03%]
第三代EGFR-TKI联合胸部放疗初治EGFR突变型NSCLC放射性肺炎的发病率和危险因素的再评估
Shuyue Zheng,Wenxiao Jia,Xuquan Jing et al.
Shuyue Zheng et al.
This single-center retrospective study evaluated radiation pneumonitis (RP) in 209 treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC) patients receiving first-line third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) plu...
Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival [0.03%]
与乳腺癌生存相关的细胞分裂和衰老的表观遗传标志物
Luca Li,Elaheh Zarean,Danmeng Lily Li et al.
Luca Li et al.
Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this ...
Herpes Zoster as a Marker of Occult Malignancy in Older Adults: A Real-World Cohort Study [0.03%]
带状疱疹作为老年人潜在恶性肿瘤标志的实证队列研究
Shih-Wei Lai,Kuan-Fu Liao
Shih-Wei Lai
This study aimed to evaluate whether herpes zoster (HZ) is associated with an increased short-term probability of newly diagnosed cancer in older adults, and to determine whether HZ may serve as an early clinical marker of occult cancer. We...
Obesity-Driven Early-Onset Colorectal Cancer: Mechanistic Insights and Emerging Clinical Implications [0.03%]
肥胖驱动的早期结直肠癌：机制见解和临床意义的新认识
Jian Liu,Jia Lu,Cuihong Dai et al.
Jian Liu et al.
Early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before 50 years of age, has increased markedly over the past decades, especially in high-income settings. In parallel, obesity and related metabolic disturbances ...