Blood-Based Circulating Tumor DNA Assays for Early Colorectal Cancer Detection: A Systematic Review of Performance in Asymptomatic Screening Populations [0.03%]
基于血液的循环肿瘤DNA检测在无症状结直肠癌筛查人群中的系统评价
Caroline Ledertoug Kahn,Maria Wissing Rasmussen,Jakob Kleif et al.
Caroline Ledertoug Kahn et al.
Early detection of colorectal cancer (CRC) via population-based screening programs can reduce incidence and mortality. Current screening approaches are limited by cost, accessibility, compliance, and colonoscopy capacity. Blood-based screen...
Transcriptome-Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment [0.03%]
基于转录组的胰腺导管腺癌切除术后的分类可增强辅助治疗后总体生存率预测模型的准确性
Marjolein F Lansbergen,Vincent R Lanting,Paul Manoukian et al.
Marjolein F Lansbergen et al.
In pancreatic ductal adenocarcinoma, patient outcomes after resection remain highly variable. Prognostic models are often inaccurate. Our study aimed to improve survival prediction by adding transcriptome-based classification to a validated...
The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition [0.03%]
新型评分系统预测免疫检查点抑制剂治疗黑色素瘤患者血栓事件的风险
Tim Zell,Julian Kött,Noah Zimmermann et al.
Tim Zell et al.
Venous and arterial thromboembolic events (TEEs) represent a substantial threat for melanoma patients treated with immune checkpoint inhibition (ICI) and have a significant impact on quality of life, therapy outcome, and survival. Existing ...
Lymphocyte Micronucleus Formation Is Driven by Inflammation-Induced Oxidative DNA Damage in Oesophageal Cancer Development [0.03%]
氧化DNA损伤驱动淋巴细胞微核形成参与食管癌发生发展
Kathryn Munn,Rachel Lawrence,Hasan Haboubi et al.
Kathryn Munn et al.
We investigated mechanisms underlying circulating DNA damage across the gastro-oesophageal reflux disease (GORD), Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) spectrum using the lymphocyte micronucleus (MN) assay. MN frequ...
Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average-Risk Populations, and Future Directions [0.03%]
人工智能在林奇综合征结肠镜监测中的应用：现有证据、从普通风险人群中学到的经验及未来发展方向
Robert Hüneburg,Querijn N E van Bokhorst,Evelien Dekker et al.
Robert Hüneburg et al.
Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma-carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally...
Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma [0.03%]
异体CAR-T的制备可避免胶质母细胞瘤患者自体CAR-T功能缺陷的问题
Sabra K Salim,Muhammad Vaseem Shaikh,Jeffrey Wei et al.
Sabra K Salim et al.
Glioblastoma (GBM) is the most common malignant brain tumor in adults, with a poor prognosis despite aggressive standard of care. Chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results in liquid malignancies, but clini...
Tumor Infiltrating Lymphocyte Therapy Combined With PD-1/LAG-3 Inhibition in Patients With Recurrent Platinum-Resistant Ovarian Cancer [0.03%]
肿瘤浸润淋巴细胞联合PD-1/LAG-3抑制在复发性铂耐药卵巢癌患者中的治疗效果研究
Tine J Monberg,Cathrine L Lorentzen,Marie C W Westergaard et al.
Tine J Monberg et al.
Patients with ovarian cancer (OC) have not yet benefitted from the advances in immuno-oncology. While tumor infiltrating lymphocytes (TILs) can be expanded from OC tumors, previous trials have not demonstrated lasting responses. High expres...
Association of Cancer Care Quality Certification With Survival Across Multiple Cancer Types: A Population-Based Cohort Study in Taiwan [0.03%]
台湾多中心癌症的癌症护理质量认证与生存关系：基于人口的队列研究
Hsiao-Chen Chiu,Chun-Ju Chiang,Jing-Rong Jhuang et al.
Hsiao-Chen Chiu et al.
Cancer remains a major global health burden. Taiwan launched the Cancer Care Quality Certification (CCQC) program in 2008; however, comprehensive evaluations of its association with survival across multiple cancer types remain limited. A to...
Clinical Benefit and Safety of Combined Immunotherapy and Targeted Therapy in Prostate Cancer [0.03%]
前列腺癌免疫治疗与靶向治疗联合应用的临床疗效及安全性
Zeyu Han,Xianyanling Yi,Yaxiong Tang et al.
Zeyu Han et al.
Although immunotherapy has transformed the treatment of several genitourinary malignancies, its role in prostate cancer remains limited. Combining immunotherapy with targeted therapies has emerged as a promising approach to enhance immune r...
Evaluating the Impact of Age on Prostate Cancer Overdiagnosis Using Long-Term Follow-Up From the CAP Randomised Trial [0.03%]
CAP随机试验长期随访评估年龄对前列腺癌过诊断影响的研究
Adam R Brentnall,Matejka Rebolj,Peter Sasieni et al.
Adam R Brentnall et al.
Prostate cancer overdiagnosis is detection of prostate cancer through PSA testing that otherwise would not have been diagnosed within the patient's lifetime. It is a major concern to policymakers due to its impact on quality of life. We use...