Derivation and Validation of a Predictive Model for Advanced Colorectal Neoplasia Among Average-Risk Adults in China [0.03%]
中国普通成年人群腺瘤性结直肠息肉的预测模型的建立和验证
Yan Liu,Yanxiu Liu,Yukun Feng et al.
Yan Liu et al.
As the burden of colorectal cancer (CRC) continues to rise and current screening methods have limitations in efficiency and accuracy, there is an urgent need particularly in China and other large populations to develop and validate precisio...
Adverse Health Events in Chronic Myeloid Leukaemia Patients Treated With Tyrosine Kinase Inhibitors 2009-2019: A Real-World Study From the UK's Haematological Malignancy Research Network [0.03%]
英国血液恶性肿瘤研究网络2009至2019年酪氨酸激酶抑制剂治疗慢性髓系白血病患者负面健康事件的真实世界研究报告
Eleanor Kane,Alexandra Smith,Debra Howell et al.
Eleanor Kane et al.
Outcomes among patients with chronic myeloid leukaemia (CML) improved markedly when tyrosine kinase inhibitors (TKIs) were introduced into routine clinical practice around the turn of the century. Nonetheless, adverse events still occur, su...
Chemotherapy-Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline-Free Regimen With Docetaxel, Cyclophosphamide-Results From a Randomized Clinical Trial [0.03%]
一项随机临床试验：氟尿嘧啶、表柔比星和环磷酰胺序贯多西他赛与无蒽环类药物的方案 docetaxel-cyclophosphamide 治疗早期乳腺癌患者的恶心呕吐作用的比较（辅助化疗）
Manuel Hörner,Henning Schäffler,Lothar Häberle et al.
Manuel Hörner et al.
Chemotherapy-induced nausea and vomiting (CINV) remains an important side effect despite new antiemetic drugs. This study tried to understand the occurrence of CINV in patients receiving two different chemotherapy regimens. As part of the r...
Targeting HIF as a Promising Approach to Synergize With Immune Checkpoint Inhibitors [0.03%]
靶向HIF与免疫检查点抑制剂协同作用的潜力
Shuai Li,Yi Liu,Xiaoli Liu et al.
Shuai Li et al.
In solid tumors, hypoxia-inducible factor (HIF) is upregulated in various cell types within the tumor microenvironment (TME) due to hypoxia. In tumor cells, HIF signaling acts as a primary driver: it triggers metabolic reprogramming toward ...
HPV-Related Cancers in Solid Organ Transplant Recipients: A Nationwide Danish Cohort Study [0.03%]
丹麦全国范围内与移植器官接受者的HPV相关的癌症关系的队列研究
Signe Timm,Flemming Skjøth,Torben Frøstrup Hansen et al.
Signe Timm et al.
Human papillomavirus (HPV) is a major cause of several epithelial cancers. Solid organ transplant recipients (SOTRs) are chronically immunosuppressed, but population-based estimates of HPV-related cancer risk across transplanted organs and ...
Real-World Outcomes of Nivolumab and Ipilimumab in Metastatic Melanoma as Third Line and Beyond [0.03%]
纳武单抗和伊匹木单抗三线治疗晚期黑色素瘤的临床疗效分析
Yago Garitaonaindia,Søren Kjær Petersen,Louise M Guldbrandt et al.
Yago Garitaonaindia et al.
Nivolumab plus ipilimumab has demonstrated activity after anti-PD-1 failure in advanced melanoma, but its effectiveness in later lines and as rechallenge remains unclear. We aimed to characterize outcomes of nivolumab/ipilimumab administere...
Mental Health Conditions and Incident Cancer: A Prospective Cohort Study of 402,255 UK Biobank Participants [0.03%]
一项针对402255名英国生物银行参与者的前瞻性队列研究：精神健康状况与癌症新发病例的关系
Mohammed Sherif Amin,Solange Parra-Soto,Ziyi Zhou et al.
Mohammed Sherif Amin et al.
Mental health conditions (MHCs) affect both psychological health and biological systems and have also been linked to cancer risk. However, evidence from epidemiological studies regarding this link remains inconsistent. We conducted a popula...
Indirect Comparison of Neoadjuvant Treatment Strategies for Muscle-Invasive Bladder Cancer: ddMVAC and Perioperative Durvalumab-Gemcitabine-Cisplatin Versus Gemcitabine-Cisplatin: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials [0.03%]
新辅助治疗肌层浸润性膀胱癌的间接比较：ddMVAC与围手术期度伐利尤单抗-吉西他滨-顺铂对比单纯吉西他滨-顺 platinum：系统评价和网状meta分析
Maurin Helen Mangold,Gloria Baumann,Victoria Luise Simone Wieland et al.
Maurin Helen Mangold et al.
For cisplatin-eligible patients with muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC), neoadjuvant cisplatin-based chemotherapy (NAC) is standard of care. More intensive regimens such as dose-dense methotrexate, vinb...
Health Care Policy Implementation Trial of Primary Human Papillomavirus-Based Cervical Screening in Denmark [0.03%]
丹麦以人乳头瘤病毒为基础的宫颈癌初筛保健政策实施试验研究
Jesper Bonde,Jeppe Bennekou Schroll,Birgitte Tønnes Pedersen et al.
Jesper Bonde et al.
On mandate from the Danish Health Authority, a nationwide health care policy trial (HCP) of primary HPV screening for women aged 30-59 was initiated in 2021. The aim was to inform on the performance of HPV screening in comparison to existin...
Prognostic Value of Perioperative Anemia in Neurosurgical-Oncological Treatment of Spinal Metastases [0.03%]
脊柱转移瘤神经外科肿瘤治疗中的围手术期贫血预后价值
Marija Janjic,Logman Khalafov,Juliane Dittmer et al.
Marija Janjic et al.
Neurosurgical resection of spinal metastases is an established treatment option for selected patients with advanced malignancies. However, high perioperative morbidity and mortality may further compromise outcomes in this vulnerable populat...