Exploring the Role of Surgery After Systemic Therapy in Locally Advanced Biliary Tract Cancer: Outcomes From a Large Retrospective Multinational Real-World Cohort Treated With Cisplatin, Gemcitabine, and Durvalumab [0.03%]
系统治疗后局部晚期胆道癌手术作用的多国大型真实世界队列研究：顺铂、吉西他滨和度伐利尤单抗的治疗结局
Margherita Rimini,Angela Lamarca,Masafumi Ikeda et al.
Margherita Rimini et al.
Surgery after response to first-line chemoimmunotherapy may offer a potential curative option for patients with locally advanced biliary tract cancer (BTC) initially considered unresectable. However, robust real-world evidence in this setti...
Deni Study: Real-World Data on the Use of Nirogacestat in Patients With Desmoid Tumors in the French Sarcoma Group [0.03%]
尼若加司特治疗_desmoid肿瘤的现实世界研究：法国肉瘤组织患者的用药数据
Pierre Kubicek,Catherine Guérin-Charbonnel,Maud Toulmonde et al.
Pierre Kubicek et al.
The DeFi trial revealed a significant improvement in progression-free survival (PFS) with nirogacestat in patients with desmoid tumors. The DeNi study reports outcomes of patients treated with nirogacestat through the French compassionate u...
Yiyin Ma,Dedian Chen,Sheng Huang
Yiyin Ma
With improved prognosis in early HER2-positive breast cancer, safely de-escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de-escalation strategies for HER2-positive breast cance...
Neoadjuvant Chemotherapy Versus Upfront Surgery for cT2N1 or cT3a-bN0-1 Middle-High Rectal Cancer [0.03%]
局部进展期中高位直肠癌新辅助化疗与 upfront 手术的比较研究
Jiahao Zhou,Yu Shen,Wenyu Huang et al.
Jiahao Zhou et al.
The optimal treatment strategy for patients with middle-high rectal cancer staged as cT2N1 or cT3a-bN0-1 without mesorectal fascia (MRF) involvement remains uncertain. Although guidelines suggest that neoadjuvant chemotherapy (NCT) or upfro...
Global Annualized Recurrence Rates and Dynamic Risk Profiles in Head and Neck Cancer [0.03%]
头颈癌的全球年度复发率和动态风险分析
Yiqiao Fang,Cheng Yi,Ruonan Sun et al.
Yiqiao Fang et al.
Recurrence limits survival in head and neck cancer (HNC), yet its annualized rate remains poorly defined due to heterogeneous follow-up durations across studies. In this systematic review and meta-analysis, we searched four databases from i...
Jing Liu,Marc A Schneider,Julia Held et al.
Jing Liu et al.
BTB and CNC homolog 1 (BACH1) is a redox-sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance...
Effects of Hippocampal Avoidance on Anxiety in Patients With Nasopharyngeal Carcinoma Undergoing Intensity-Modulated Radiotherapy: A Single-Center, Single-Arm, Prospective Clinical Trial [0.03%]
海马回避对接受调强放疗的鼻咽癌患者焦虑的影响：单中心前瞻性临床研究
Xiujuan Gai,Shiqi Huang,Jinru Ye et al.
Xiujuan Gai et al.
This study aimed to investigate whether hippocampal avoidance (D40 < 15 Gy) could reduce anxiety incidence in patients with nasopharyngeal carcinoma (NPC) undergoing intensity modulated radiation therapy (IMRT), and to dynamically assess th...
Timing of Adjuvant Imatinib Initiation and Recurrence-Free Survival After Curative Resection for Intermediate- and High-Risk Gastrointestinal Stromal Tumors: A Multicenter Real-World Cohort Study [0.03%]
辅助伊马替尼起始时机与胃肠道间质瘤根治术后无复发生存的关联：一项多中心真实世界队列研究
Zhiming Cai,Huimei Lin,Zihan Lin et al.
Zhiming Cai et al.
Adjuvant imatinib reduces recurrence risk after curative resection for intermediate- and high-risk gastrointestinal stromal tumors, but the optimal timing of postoperative initiation remains unclear. This multicenter real-world cohort study...
Mid- and Long-Term Risk of Venous Thromboembolism Among Female Breast Cancer Survivors: A Nationwide Cohort Study [0.03%]
丹麦女性乳腺癌幸存者静脉血栓栓塞的中长期风险——全国队列研究
Jihun Kang,Wonyoung Jung,Bongseong Kim et al.
Jihun Kang et al.
Venous thromboembolism (VTE) is a serious complication for breast cancer (BC) survivors. We identified records of female BC survivors from the Korean Health Insurance Service database between January 1, 2010, and December 31, 2016. After ap...
The Association Between Human Papillomavirus and Prostate Cancer: A Systematic Review and Meta-Analysis [0.03%]
人乳头瘤病毒与前列腺癌关系的系统评价和 meta 分析
Sarah Botting-Provost,Kristy Ng,Cassandra Laurie et al.
Sarah Botting-Provost et al.
Human papillomavirus (HPV), the necessary cause of cervical cancer, is associated with an increased risk of other anogenital cancers. While HPV has frequently been detected in prostate specimens, its role in prostate carcinogenesis remains ...