Reprogramming innate immunity to overcome endocrine resistance in estrogen receptor-positive breast cancer [0.03%]
重编程先天性免疫以克服雌激素受体阳性乳腺癌的内分泌耐药性
Siti Nur Hasyila Muhammad,Maryam Azlan,Agustine Nengsih Fauzi
Siti Nur Hasyila Muhammad
Estrogen receptor-positive (ER+) breast cancer accounts for the majority of breast cancer cases worldwide, yet the long-term efficacy of endocrine therapy is limited by resistance and recurrence. While tumor-intrinsic mechanisms of endocrin...
Real-world progression-free survival and overall survival in patients with HR+/HER2- advanced breast cancer treated in first-line with ribociclib, endocrine monotherapy or chemotherapy: Results from the observational RIBANNA study [0.03%]
RIBANNA观察性研究：HR+/HER2-一线接受Ribociclib、内分泌单药或化疗的晚期乳腺癌患者的真实世界无进展生存期和总生存期
Peter A Fasching,Cosima Brucker,Thomas Decker et al.
Peter A Fasching et al.
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy are the preferred choice for first-line treatment of patients with HR+/HER2- locally advanced/metastatic breast cancer (aBC). The CDK4/6i ribociclib in com...
PVT1 lincRNA signals an androgen-dependent transcriptional activation program of oncogenes in prostate cancer cells [0.03%]
前列腺癌细胞中PVT1长链非编码RNA信号转导雄激素依赖性原癌基因转录激活程序
Maria Gabriela Berzoti-Coelho,Fabio Nunes de Mello,Ana Carolina Tahira et al.
Maria Gabriela Berzoti-Coelho et al.
Prostate cancer is the most prevalent malignancy among men and is driven by multiple factors, including androgen signaling and its receptor. Long non-coding RNAs, such as PVT1, play key roles in cancer, particularly by regulating gene expre...
Association of predicted body compositions with the risk of colorectal cancer in the Chinese population: A 15-year prospective cohort [0.03%]
基于中国人群的15年前瞻性队列研究：预测体质成分与结直肠癌风险的关系
Junying Hao,Shilong Dai,Mingjun Wang et al.
Junying Hao et al.
Given that body mass index (BMI) fails to distinguish between fat and muscle, and that the relationship between body composition and colorectal cancer (CRC) risk in the Chinese population is insufficiently understood, we prospectively exami...
Long-term benefit from adjuvant tamoxifen therapy for ER+ HER2- breast cancer by PR positivity [0.03%]
阳性孕激素受体对ER阳性HER2阴性乳腺癌辅助托瑞米芬治疗的长期益处
Anna E Nordenskjöld,Magdalena Ríos-Romero,Huma Dar et al.
Anna E Nordenskjöld et al.
We aimed to evaluate the long-term tamoxifen benefit by progesterone receptor (PR) levels in postmenopausal lymph node-negative breast cancer patients with estrogen receptor (ER)-positive/human epidermal growth factor receptor 2-negative (H...
Systemic anti-cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy [0.03%]
系统抗癌治疗诱发周围神经毒性和外周神经病变发生的相关性分析
Cassie Higgins,Lynn R Gauthier,Blair H Smith et al.
Cassie Higgins et al.
The investigation of peripheral neurotoxicity associated with systemic anticancer therapy (SACT) agents is often confined to a small range of chemotherapy agents. This study aimed to identify all SACT agents associated with peripheral neuro...
Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma [0.03%]
黏附连接蛋白表达与食管腺癌新辅助FLOT化疗反应差及促炎性肿瘤微环境相关
Bastian Grothey,Heike Löser,Tillmann Bedau et al.
Bastian Grothey et al.
Esophageal adenocarcinoma (EAC) demonstrates poor survival rates despite multimodal treatments, with significant inter-patient variability in response to standard pre-/perioperative therapies. This study investigates the relationship betwee...
Toward a validated European instrument to measure the socioeconomic impact of cancer [0.03%]
迈向有效的欧洲癌症社会经济影响测量工具
Jasper Ubels,Julie M Vancoppenolle,Josephine Tetteh et al.
Jasper Ubels et al.
A cancer diagnosis can impose a financial burden on patients and their families, defined as socio-economic impact (SEI) within a framework of the Organization of European Cancer Institutes (OECI). The Socio-Economic Consequences of Cancer (...
Risk of childhood and adolescent, and young adult cancer in offspring of men with testicular cancer: A Danish nationwide study [0.03%]
父亲患睾丸癌的儿童及青年人群癌症发病风险：一项丹麦全国性研究
Mikkel Bandak,Susanne Rosthøj,Gitte Lerche Aalborg et al.
Mikkel Bandak et al.
Data on cancer risk in offspring of men with testicular germ cell cancer (TC) remain limited. We assessed the risk of childhood and adolescent and young adult (AYA) cancer in offspring of men with TC. Men diagnosed with TC in the Danish Can...
Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab-paclitaxel [0.03%]
肿瘤治疗场（TTFields）联合吉西他滨/白蛋白结合型紫杉醇在胰腺导管腺癌预临床模型中的疗效和免疫原性作用研究
Tal Kan,Tharwat Haj Khalil,Yiftah Barsheshet et al.
Tal Kan et al.
Tumor Treating Fields (TTFields) are an approved cancer therapy for glioblastoma (GBM), pleural mesothelioma, and non-small cell lung cancer (NSCLC). A recent phase 3 trial of TTFields therapy concomitant with standard-of-care gemcitabine a...