Nationwide audit of cervical cancer screening reveals unsatisfactory triage strategies and trends over time in incidence among cytology negative women [0.03%]
全国宫颈癌筛查审计揭示了阴性细胞学检查妇女中不令人满意的分流策略及随时间变化的发病率趋势
Cecilia Kärrberg,Penelope Gray,Kristina Elfgren et al.
Cecilia Kärrberg et al.
Regular audits are essential for monitoring and evaluation of cervical screening. We audited the Swedish cervical screening program during the transition to HPV-based screening using a registry-based cohort design. In total, 5689 consecutiv...
A cost-effectiveness analysis of breast cancer treatment in certified versus non-certified hospitals in Germany [0.03%]
德国认证与非认证医院乳腺癌治疗的成本效益分析
Min-Wai Lwin,Olaf Schoffer,Christoph Streissnig et al.
Min-Wai Lwin et al.
In Germany, the German Cancer Society (Deutsche Krebsgesellschaft [DKG]) accredits hospitals to ensure high-quality cancer treatment through adherence to clinical guidelines and a multidisciplinary approach. Evidence suggests certified hosp...
Cyclin-dependent kinases as therapeutic targets in cancer: Recent advances, challenges, and opportunities [0.03%]
细胞周期依赖性激酶在癌症治疗中的作用：近期进展、挑战和机遇
Ning Ju,Li Zhao,Shanshan Yin et al.
Ning Ju et al.
Dysregulated cell cycle progression drives uncontrolled proliferation and is a fundamental hallmark of cancer, making cyclin-dependent kinases (CDKs), which largely govern cell-cycle progression and cell division, attractive therapeutic tar...
Prevalence and distribution of HPV types in Australian patients with oropharyngeal cancer over time [0.03%]
澳大利亚头颈部鳞癌患者人乳头瘤病毒类型的分布变迁研究
Lachlan Yaksich,Gunter Hartel,Benedict J Panizza et al.
Lachlan Yaksich et al.
The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is increasing in Australia, yet very little is known about the dynamics of the HPV types in OPC over time. Here we used a database to identify oropharyngeal can...
Unraveling glymphatic disruption in brain tumors: Insights from perivascular space network analysis [0.03%]
脑肿瘤甘淋巴系统紊乱的解谜：基于血管周围空间网络分析的见解
Min Gao,Hongjing Zang,Wei Zhao et al.
Min Gao et al.
Brain tumors disrupt the glymphatic system-a critical network for cerebrospinal and interstitial fluid circulation via the perivascular spaces (PVS)-yet the extent and underlying mechanisms of this dysfunction remain poorly defined. In a pr...
Tolerability and efficacy of chemosaturation in combination with systemic therapy for metastatic uveal melanoma [0.03%]
化学饱和联合全身治疗适应性眼脉络膜黑色素瘤的耐受性和疗效
Patrick Kasteleiner,Gerd Grözinger,Jörg Schmehl et al.
Patrick Kasteleiner et al.
Uveal melanoma is the most common primary intraocular malignancy in adults. Metastatic disease occurs in approximately 40%-50% of patients, the liver being the predominant site of metastasis (>90%). Treatment options include immune checkpoi...
Clinicopathological and genomic features of early-onset non-small cell lung cancer across age and ethnicity [0.03%]
基于年龄和种族的早期发病非小细胞肺癌的临床病理及基因组特征分析
Pingzhi Huang,Jialin Song,Jun Liu et al.
Pingzhi Huang et al.
Lung cancer in young patients shows a rising incidence and distinct disease biology but remains understudied. We obtained clinical information and somatic mutation data for two large non-small-cell lung cancer (NSCLC) patient cohorts from t...
Tumor-educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation [0.03%]
肿瘤教育血小板在癌症诊断和预后中的作用：批判性评价及临床转化路线图
Whi-An Kwon,Min-Kyung Lee,Eunyong Ahn et al.
Whi-An Kwon et al.
Tumor-educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor-derived biomolecules. This interaction imprints an integrated molecular signat...
Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer [0.03%]
arp2/3复合物和β1整合素通过适应细胞外基质促进胰腺癌的侵袭性前沿发展
Xiufen Yang,Yina Qiao,Yifeng Sun et al.
Xiufen Yang et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, due to its aggressive invasiveness and resistance to therapy. The dense, stiff extracellular matrix, composed primarily of collagen I and basement membrane compon...
TP53 mutation is associated with improved disease control in patients with advanced RAS wild-type colorectal adenocarcinoma treated with cetuximab and pembrolizumab [0.03%]
TP53突变与西妥昔单抗和派姆单抗治疗的RAS野生型晚期结肠腺癌患者疾病控制改善相关
Christos Fountzilas,Spencer Rosario,Agnieszka K Witkiewicz et al.
Christos Fountzilas et al.
Immunotherapy with checkpoint inhibitors targeting the PD1/PD-L1 and CTLA4 pathways has limited activity in patients with microsatellite stable (MSS) colorectal adenocarcinoma (CRC). In a prior study, the combination of cetuximab and pembro...