Impact of non-genetic heterogeneity of BRAF-mutant colon cancer organoids on growth kinetics, drug sensitivity and Wnt dynamics [0.03%]
BRAF突变型结直肠癌类器官非遗传异质性对生长动力学、药物敏感性和Wnt动态的影响
Viktoria Zieger,Ellen Woehr,Jasmin Traichel et al.
Viktoria Zieger et al.
Patient-derived organoid (PDO) models are powerful systems for studying tumor biology and drug response. By retaining genetic, histological, and functional characteristics of the original tumor, including intra- and interpatient heterogenei...
Real-world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone in patients with or without melanoma brain metastasis: Results from the German noninterventional NICO study [0.03%]
尼伏单抗联合伊匹单抗或单用尼伏单抗治疗伴或不伴黑色素瘤脑转移的患者：德国非干预性NICO研究的有效性和安全性结果
Ralf Gutzmer,Michael Weichenthal,Thomas Eigentler et al.
Ralf Gutzmer et al.
The prospective, German NICO study (ClinicalTrials.gov identifier: NCT02990611) evaluated real-world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone (any-line) in patients with advanced melanoma with/without melan...
Lung cancer as a global health challenge: Multidimensional biomarker research and therapeutic advances [0.03%]
作为全球健康挑战的肺癌：多维度生物标志物研究和治疗进展
Dezhong Jin,Liangwang Zhong,Lai Chen
Dezhong Jin
Lung cancer, the leading cause of global cancer-related mortality, is categorized into small-cell and non-small-cell subtypes. The heterogeneous non-small-cell lung cancer group is further subcategorized primarily into adenocarcinoma, squam...
Treatment patterns and clinical outcomes in real-world patients with small-cell lung cancer in South Korea: A single-center experience [0.03%]
韩国真实世界小细胞肺癌患者的治疗模式和临床结局：单中心经验报告
Sehhoon Park,Danbee Kang,Jin Lee et al.
Sehhoon Park et al.
We examined treatment patterns and overall survival (OS) among patients with small-cell lung cancer (SCLC) in South Korea. This retrospective cohort study included patients with SCLC treated at Samsung Medical Center between January 1, 2018...
Cancer care in Afghanistan: A comprehensive analysis of opportunities and challenges in a low-income and conflict-affected country [0.03%]
阿富汗的癌症护理：一个低收入和冲突国家的机会与挑战的全面分析
Maihan Abdullah,Ikram Hashimi,Jesse B Bump et al.
Maihan Abdullah et al.
The main purpose of this study was to assess the cancer prevention and control capacity in Afghanistan. The study utilized the WHO/IAEA National Cancer Control Programmes (NCCP) Core Capacity Self-Assessment Tool to evaluate Afghanistan's c...
Efficacy and safety of neoadjuvant apatinib plus PD-1 inhibitor with SOX for locally advanced gastric cancer: A multicenter, retrospective cohort study [0.03%]
阿帕替尼联合PD-1抑制剂和SOX新辅助治疗局部进展期胃癌的疗效及安全性：一项多中心回顾性队列研究
Shikang Ding,Hongyun Huang,Can Cao et al.
Shikang Ding et al.
Although neoadjuvant PD-1 inhibitors combined with chemotherapy are promising for locally advanced gastric cancer (LAGC), pathological complete response (pCR) rates remain suboptimal. This multicenter retrospective study (January 2020-Septe...
Quantifying the contribution of modifiable risk factors for progression of MGUS to multiple myeloma in a Veteran population [0.03%]
评估可改变的风险因素对退伍军人群体MGUS病进展为多发性骨髓瘤的贡献大小
Mei Wang,Byron Sigel,Lawrence Liu et al.
Mei Wang et al.
Multiple myeloma (MM) is the most common plasma cell dyscrasia in the United States with tremendously high burden. MM is preceded by a premalignant condition, monoclonal gammopathy of undetermined significance (MGUS). Although several risk ...
ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance [0.03%]
ULK4和CDKN2A多态性影响未明确定义的单克隆丙球蛋白血症的风险
José Manuel Sánchez-Maldonado,Angelica Macauda,Antonio José Cabrera-Serrano et al.
José Manuel Sánchez-Maldonado et al.
Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes i...
Interplay between ER stress and DNA repair pathways in solid tumors under hypoxia [0.03%]
缺氧条件下实体瘤中内质网应激与DNA修复途径的相互作用
Aastha Jadhav,Neeru Singh
Aastha Jadhav
Solid tumors often develop a hypoxic microenvironment that triggers adaptive cellular responses, promoting tumor progression, aggressiveness, and therapeutic resistance. Hypoxia activates HIF1α, a key regulator that modulates the expressio...
Trends in the incidence of cancers of the breast and female genital tract in Harare, Zimbabwe 1990-2019 [0.03%]
1990年至2019年哈拉雷女性乳腺和生殖道癌症的发病率趋势
Eric Chokunonga,Zvavahera Michael Chirenje,Margaret Borok et al.
Eric Chokunonga et al.
Trends in age standardised incidence rates (ASRs) in the black (African) female population of Harare are reported for five cancers-of the breast and genital tract (cervix and corpus uteri, ovary and vulva) over a 30-year period. The inciden...