Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization [0.03%]
自噬相关基因多态性作为胰腺癌易感生物标志物的-meta分析及功能表型研究
Fernando Gálvez-Montosa,Giulia Peduzzi,José Manuel Sanchez-Maldonado et al.
Fernando Gálvez-Montosa et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy-relat...
The risk of treatment-related toxicities with PD-1/PD-L1 inhibitors in patients with lung cancer [0.03%]
肺癌患者使用PD-1/PD-L1抑制剂治疗的相关毒性风险
Hao Hu,Qian Zhu,Hua Tang et al.
Hao Hu et al.
The risk of treatment-related toxicities with programmed cell death 1 and its ligand (PD-1/PD-L1) inhibitors in patients with lung cancer is unclear and inconclusive. PubMed, EMBASE, and the Cochrane Library databases were systematically se...
Potentially functional variants of PARK7 and DDR2 in ferroptosis-related genes predict survival of non-small cell lung cancer patients [0.03%]
与铁死亡相关基因PARK7和DDR2的潜在功能性变异预测非小细胞肺癌患者的生存率
Huilin Wang,Hongliang Liu,Xiaozhun Tang et al.
Huilin Wang et al.
Ferroptosis, a form of regulated cell death, is characterized by iron-dependent lipid peroxidation. It is recognized increasingly for its pivotal role in both cancer development and the response to cancer treatments. We assessed association...
Oligometastatic non-small cell lung cancer: Impact of local and contemporary systemic treatment approaches on clinical outcome [0.03%]
寡转移非小细胞肺癌：局部及当代系统性治疗对临床结局的影响
Marcel Wiesweg,Claudia Küter,Johannes Schnorbach et al.
Marcel Wiesweg et al.
Oligometastatic (OMD) non-small cell lung cancer (NSCLC) is a distinct but heterogeneous entity. Current guidelines recommend systemic therapy and consolidation with local ablative therapy (LAT). However, evidence regarding the optimal choi...
Multicenter Study
International journal of cancer. 2025 Feb 15;156(4):776-787. DOI:10.1002/ijc.35199 2025
Johannes Duell,Jason Westin
Johannes Duell
With the introduction of anti-CD19 chimeric antigen receptor (CAR) T-cell (CAR T) therapies, bispecific CD3/CD20 antibodies and anti-CD19 antibodies, immunotherapy continues to transform the treatment of diffuse large B-cell lymphoma (DLBCL...
Clinically validated HPV assays offer comparable long-term safety in primary cervical cancer screening: A 9-year follow-up of a population-based screening cohort [0.03%]
临床验证过的HPV检测在初次宫颈癌筛查中的长期安全性能相仿：一项基于人群的筛查队列的9年随访研究
Anja Oštrbenk Valenčak,Kelsi R Kroon,Danijela Fabjan et al.
Anja Oštrbenk Valenčak et al.
Molecular testing for human papillomaviruses (HPV) is gradually replacing cytology in cervical cancer screening. In this longitudinal population-based cohort study, 4140 women 20 to 64 years old attending organized screening were tested at ...
Circulating tryptophan-kynurenine pathway metabolites are associated with all-cause mortality among patients with stage I-III colorectal cancer [0.03%]
色氨酸犬尿素途径代谢物与I-III期结直肠癌患者全因死亡率相关性研究
Victoria Damerell,Niels Klaassen-Dekker,Stefanie Brezina et al.
Victoria Damerell et al.
Alterations within the tryptophan-kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we i...
New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities [0.03%]
肾细胞癌骨转移领域的新角色和治疗机会
Beatrice Cesana,Claude Cochet,Odile Filhol
Beatrice Cesana
Approximately one-third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective of seminal studies on bone metastasi...
Profound primary prevention of liver cancer following a natural experiment in China: A 50-year perspective and public health implications [0.03%]
中国一次自然实验后深度预防肝癌的深远影响：50年回顾与公共卫生启示
Jian-Guo Chen,Thomas W Kensler,Jian Zhu et al.
Jian-Guo Chen et al.
Liver cancer causes upwards of 1 million cancer deaths annually and is projected to rise by at least 55% over the next 15 years. Two of the major risk factors contributing to liver cancer have been well documented by multiple epidemiologic ...
Postmarketing adverse events of tamoxifen in male and female patients with breast cancer [0.03%]
他莫昔芬在男性和女性乳腺癌患者中的上市后不良事件
Chengjie Ke,Maohua Chen,Li Lin et al.
Chengjie Ke et al.
Tamoxifen (TAM), a selective estrogen receptor (ER) modulator, has received approval for use in patients with breast cancer (BC) exhibiting positive ER expression. Given the widespread clinical use of TAM, a comprehensive real-world study o...