Harnessing normalcy: The potential of healthy tissue for patient outcomes [0.03%]
利用正常组织：其对患者预后的潜在价值
Chiara Papulino,Rosaria Benedetti,Lucia Altucci
Chiara Papulino
Patient characteristics associated with delayed time to adjuvant chemotherapy among women treated for stage I-IIIA breast cancer [0.03%]
II至III期乳腺癌患者辅助化疗延迟的相关因素分析
Jenna Bhimani,Kelli O&#x;Connell,Sonia Persaud et al.
Jenna Bhimani et al.
For patients with breast cancer, delays in chemotherapy initiation have been adversely associated with recurrence and survival. We evaluated patient-level factors associated with delayed chemotherapy initiation, from both diagnosis and surg...
Height, body mass index, physical activity, and risk of colorectal cancer in relation to expression of insulin receptor: The Japan Public Health Center-based Prospective Study [0.03%]
基于日本公共卫生中心的前瞻性研究：身高、体质指数、体力活动与结直肠癌风险及其与胰岛素受体表达的关系
Kenshiro Nishihara,Shiori Nakano,Taiki Yamaji et al.
Kenshiro Nishihara et al.
To ascertain the involvement of insulin receptors (IRs) in colorectal carcinogenesis, we investigated the association of height, body mass index (BMI), and physical activity with colorectal cancer (CRC) and two subtypes of CRC according to ...
Contemporary survival in metastatic bladder cancer patients: A population-based study [0.03%]
转移性膀胱癌患者的生存现状：基于人口的队列研究
Francesco Di Bello,Carolin Siech,Letizia Maria Ippolita Jannello et al.
Francesco Di Bello et al.
The overall survival (OS) improvement after the advent of several novel systemic therapies, designed for treatment of metastatic urothelial carcinoma of the urinary bladder (mUCUB), is not conclusively studied in either contemporary UCUB pa...
Personalized dendritic cell vaccine in multimodal individualized combination therapy improves survival in high-risk pediatric cancer patients [0.03%]
个体化树突状细胞疫苗联合治疗改善高危儿童肿瘤预后
Michal Kyr,Peter Mudry,Kristyna Polaskova et al.
Michal Kyr et al.
A lot of hope for high-risk cancers is being pinned on immunotherapy but the evidence in children is lacking due to the rarity and limited efficacy of single-agent approaches. Here, we aim to assess the effectiveness of multimodal therapy c...
Spotlight on the treatment of non-small cell lung cancer with rare genetic alterations and brain metastasis: Current status and future perspectives [0.03%]
少见基因改变非小细胞肺癌及其脑转移的治疗现状与未来展望
Qian Zhang,Kaiyan Chen,Xiaoqing Yu et al.
Qian Zhang et al.
In patients with non-small cell lung cancer (NSCLC), oncogenic variants present in
Head-to-head comparison of treatment sequences in advanced pancreatic cancer-Real-world data from the prospective German TPK clinical cohort study [0.03%]
一线治疗失败后晚期胰腺导管腺癌不同二线治疗方案的直接比较——德国前瞻性TPK临床队列研究的真实世界数据
Norbert Marschner,Nina Haug,Susanna Hegewisch-Becker et al.
Norbert Marschner et al.
There are no clear guidelines regarding the optimal treatment sequence for advanced pancreatic cancer, as head-to-head phase III randomised trials are missing. We assess real-world effectiveness of three common sequential treatment strategi...
Multi-scale brain attributes contribute to the distribution of diffuse glioma subtypes [0.03%]
多尺度脑特征有助于弥漫性胶质瘤亚型的分类分布
Peng Ren,Hongbo Bao,Shuai Wang et al.
Peng Ren et al.
Gliomas are primary brain tumors and are among the most malignant types. Adult-type diffuse gliomas can be classified based on their histological and molecular signatures as IDH-wildtype glioblastoma, IDH-mutant astrocytoma, and IDH-mutant ...
Johannes Knabbe,Thomas Kowalski,Corinna Seliger
Johannes Knabbe
Patients with brain tumors suffer from intense psychosocial distress. Although the prevalence of depressive symptoms in patients with brain tumors is high, the pharmacological antidepressant treatment of those patients is not well defined a...
KCa channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by KCa expression levels [0.03%]
钾钙通道定位损伤患者衍生的胶质母细胞瘤干细胞的DNA修复和侵袭性，这在很大程度上不能仅通过KCa表达水平预测
Katrin Ganser,Nicolai Stransky,Tayeb Abed et al.
Katrin Ganser et al.
Prognosis of glioblastoma patients is still poor despite multimodal therapy. The highly brain-infiltrating growth in concert with a pronounced therapy resistance particularly of mesenchymal glioblastoma stem-like cells (GSCs) has been propo...