Oncotype DX: Clinical Utility, Evidence, and Future Trends in Personalized Breast Cancer Management [0.03%]
OncoType Dx：个性化乳腺癌管理的临床应用价值、证据及未来趋势
Robert Le Yang,Yiran Liang
Robert Le Yang
The Oncotype DX assay has revolutionized the management of early-stage, hormone receptor-positive, HER2-negative breast cancer. Developed in 2004, it quantifies 21 genes to generate a recurrence score that predicts distant recurrence risk a...
Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers [0.03%]
BRCA1和BRCA2基因突变携带者感染幽门螺旋杆菌的情况及其危险因素分析
Kole H Buckley,Yuhan Zhu,Kevin Dinh et al.
Kole H Buckley et al.
Recent evidence suggests that carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 may have an increased risk of gastric cancer (GC). However, the specific mechanisms underlying gastric carcinogenesis remain uncertain. Striking...
Comments on "Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average-Risk Populations, and Future Directions" [0.03%]
关于“Lynch综合征结肠镜监测的人工智能：来自普通风险人群的新兴证据、经验教训和未来方向”的评论
Zekai Yu,Wei Xiong,Haoyang Hu et al.
Zekai Yu et al.
Liver Cancer Risk and Incidence Attributable to Human Immunodeficiency Virus: A Meta-Analysis and Population-Attributable Modeling Study of Over 1.2 Million Individuals [0.03%]
一项针对120多万人的meta分析和人群归因模型研究：人类免疫缺陷病毒感染带来的肝癌风险及发病率
Jianhui Zhao,Kangning Li,Yixuan Zhang et al.
Jianhui Zhao et al.
HIV-induced immune suppression and chronic inflammation elevate the risk of cancer progression. We conducted a systematic review and meta-analysis of studies published between January 1, 1984 and October 13, 2023 to assess the association b...
Clinical Utility of Cytological Methylation Assay in Cervical Cancer Screening Across Various Cervical Transformation Zones [0.03%]
宫颈转化区不同区域细胞学甲基化检测筛查宫颈癌的临床应用价值研究
Xiaoying Zhong,Xitong Jin,Yanan Cheng et al.
Xiaoying Zhong et al.
Type I to III cervical transformation zones (TZ-1 to TZ-3) may have various effects on cervical cancer screening and diagnostic outcomes. This study aims to evaluate the clinical utility of the cytological PAX1/JAM3 methylation (CISCER) ass...
Surgical Removal of Residual Tumor Masses in Patients Undergoing Targeted Therapy for EGFR-Mutated Locally Advanced or Metastatic Lung Cancer [0.03%]
表皮生长因子受体突变的局部晚期或转移性肺癌靶向治疗患者残存肿瘤组织的手术切除疗效分析
Fedor Moiseenko,Daniil Stroyakovskiy,Evgeniy Levchenko et al.
Fedor Moiseenko et al.
Non-small cell lung cancer (NSCLC) patients with EGFR mutations usually receive continuous treatment with tyrosine kinase inhibitors (TKIs) until disease progression. We evaluated whether surgical excision of residual tumor masses offers a ...
Photodynamic Effect of Bioactive Titanium Metal Initiated by X-Ray and Its Potential Application for Bone Tumor Treatment [0.03%]
生物活性钛金属材料的光动力效应及其潜在的骨肿瘤治疗价值研究
Jun Chen,Yifan Cui,Dechao Yuan et al.
Jun Chen et al.
Bioactive titanium metals with titania/titanate surface were prepared with anodic oxidation, alkali heat, or acid-base treatment methods. It was found that the bioactive Ti could be initiated with a photodynamic effect by X-ray used for bon...
Real-World Evidence on the Efficacy of Icaritin for Unresectable Advanced Hepatocellular Carcinoma: A Multicenter Retrospective Study [0.03%]
伊卡秋汀治疗不可切除的晚期肝细胞癌真实世界疗效研究：一项多中心回顾性分析
Dinghu Zhang,Qinfen Xie,Zhewei Zhang et al.
Dinghu Zhang et al.
Icaritin's efficacy was evaluated for unresectable advanced hepatocellular carcinoma (HCC), a major global burden with limited advanced-stage treatment options. A multicenter retrospective real-world study (May 2022-May 2024) included 163 p...