Computational Analyses of Bifurcated Inter-Protein Interactions in Protein-Protein Assemblies Reveal Their Pivotal Role in Conferring Stability [0.03%]
计算分析蛋白质复合物中分叉的蛋白-蛋白相互作用揭示了其在赋予稳定性中的关键作用
Sneha Bheemireddy,Revathy Menon,Sreenivas Chavali et al.
Sneha Bheemireddy et al.
Majority of the proteome is constituted by oligomers and their function is governed by underlying protein-protein interactions. Interfacial residues, namely residues right at the interface of two protein chains, are known to confer stabilit...
Protein Involved in Initiation 1 Interaction With Starch Synthase 4 From Arabidopsis thaliana Induces Inhibition of Elongating Activity [0.03%]
来自拟南芥的参与起始1与淀粉合成酶4相互作用的蛋白质可诱发延伸活性抑制
Mélanie Bossu,Rayan Osman,Guillaume Brysbaert et al.
Mélanie Bossu et al.
Starch is the major energy storage compound in plants. It accumulates in the form of insoluble, partly crystalline granules whose number and shape are specific to each plant species. These characteristics are defined very early in starch bi...
Elucidation of Critical Amino Acid Residues for Antibody and Transmembrane Antigen Interactions via Cell-Free Protein Expression-Based Approach [0.03%]
基于细胞自由蛋白表达的方法阐明抗体与跨膜抗原相互作用的关键氨基酸残基
Mikhail S Karbyshev,Kristina O Baskakova,Pavel K Kuzmichev et al.
Mikhail S Karbyshev et al.
The generation of antibodies against integral membrane proteins (IMPs) presents unique challenges due to IMPs' low natural abundance, reduced biosynthesis rate, limited level of extraction, and low purification yield. That stems from their ...
Molecular Dynamics Identify Variances Between Galectin Carbohydrate-Binding Sites That Impact the Binding Site Conformation and Ligand Binding [0.03%]
分子动力学揭示半乳糖凝集素碳水化合物结合位点之间的差异及其对结合构象和配体结合的影响
Rob Marc Go,Chandan Kishor,Alpeshkumar K Malde et al.
Rob Marc Go et al.
Galectins are a family of carbohydrate-binding proteins that aid in the progression of pathological conditions such as inflammation, bone disease, and cancers, making them attractive drug targets. Galectins share a conserved carbohydrate re...
Zsófia E Kálmán,András Czajlik,Brigitta Maruzs et al.
Zsófia E Kálmán et al.
Homer proteins are modular scaffold molecules that constitute an integral part of the protein network within the postsynaptic density. Full-length Homer1 forms a large homotetramer via a long coiled coil region, and can interact with prolin...
Structure of the NAD+ Bound Erythrose-4-Phosphate Dehydrogenase (E4PDH) Reveals the Stabilizing Effect of Polyethylene Glycol on the Quaternary Structure [0.03%]
NAD+结合的erythrose-4-phosphate脱氢酶（E4PDH）结构显示聚乙二醇对四级结构稳定作用
Viswanathan Vijayan,Anjali Kumari,Anamika Singh et al.
Viswanathan Vijayan et al.
Erythrose-4-phosphate dehydrogenase (E4PDH, EC 1.2.1.72) from Acinetobacter baumannii (AbE4PDH) is an essential multifunctional enzyme. E4PDH catalyzes the first step of the deoxyxylulose-5-phosphate (DXP) dependent Vitamin B6 biosynthetic ...
Rieske Iron-Sulfur Cluster Proteins From an Anaerobic Ammonium Oxidizer Suggest Unusual Energetics in Their Parent Rieske/Cytochrome b Complexes [0.03%]
厌氧氨氧化古菌中的瑞斯克铁硫蛋白表明其母型瑞斯克/细胞色素b复合物具有独特的能量属性
David Hauser,Mandy Sode,Elena A Andreeva et al.
David Hauser et al.
Anaerobic ammonium-oxidizing (anammox) bacteria employ a unique, hydrazine-based pathway to obtain energy from nitrite and ammonium. These organisms possess distinct Rieske/cytochrome b complexes whose precise role in anammox metabolism rem...
Haoyang Zhang,Xinning Luan,Mauno Vihinen
Haoyang Zhang
Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense-mediated decay prevents the expression of many nucleotide deletions. Many varian...
Enhancement Effects of α4/α6-Targeted Inhibitors on Eg5-Microtubule Interaction [0.03%]
α4/α6靶向抑制剂对Eg5-微管相互作用的增强效应
Ziling Huo,Jiaxi Li,Jingyu Qin et al.
Ziling Huo et al.
Eg5 is one kind of kinesin motor that participates in various cellular processes, especially in mitosis. The tetrameric structure of Eg5 can crosslink the antiparallel microtubules and generate forces on microtubules to separate chromosomes...
Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16 [0.03%]
CASP16中RNA周围复杂水和离子团簇的盲预测
Rachael C Kretsch,Elisa Posani,Eugene F Baulin et al.
Rachael C Kretsch et al.
Biomolecules rely on water and ions for stable folding, but these interactions are often transient, dynamic, or disordered and thus hidden from experiments and evaluation challenges that represent biomolecules as single, ordered structures....