Molecular dynamics simulations to the bidirectional adhesion signaling pathway of integrin αV β3 [0.03%]
整合素αvβ3双向粘附信号通路的分子动力学模拟研究
Martin Kulke,Walter Langel
Martin Kulke
The bidirectional force transmission process of integrin through the cell membrane is still not well understood. Several possible mechanisms have been discussed in literature on the basis of experimental data, and in this study, we investig...
Unique active site formation in a novel galactose 1-phosphate uridylyltransferase from the hyperthermophilic archaeon Pyrobaculum aerophilum [0.03%]
来源于极端嗜热古菌Pyrobaculum aerophilum的新型半乳糖-1-磷酸尿苷基转移酶中独特的活性中心形成
Tatsuya Ohshida,Junji Hayashi,Kazunari Yoneda et al.
Tatsuya Ohshida et al.
A gene encoding galactose 1-phosphate uridylyltransferase (GalT) was identified in the hyperthermophilic archaeon Pyrobaculum aerophilum. The gene was overexpressed in Escherichia coli, after which its product was purified and characterized...
Structural complementarity of distance constraints obtained from chemical cross-linking and amino acid coevolution [0.03%]
基于化学交联和氨基酸协同进化的距离限制的结构互补性
Ricardo N Dos Santos,Guilherme F Bottino,Fábio C Gozzo et al.
Ricardo N Dos Santos et al.
The analysis of amino acid coevolution has emerged as a practical method for protein structural modeling by providing structural contact information from alignments of amino acid sequences. In parallel, chemical cross-linking/mass spectrome...
High-accuracy protein structures by combining machine-learning with physics-based refinement [0.03%]
结合机器学习与物理基础优化的高精度蛋白质结构预测方法
Lim Heo,Michael Feig
Lim Heo
Protein structure prediction has long been available as an alternative to experimental structure determination, especially via homology modeling based on templates from related sequences. Recently, models based on distance restraints from c...
The tripartite architecture of the eukaryotic integral membrane protein zinc metalloprotease Ste24 [0.03%]
真核膜整合蛋白的金属锌蛋白酶Ste24的三联体结构
Brandon R Goblirsch,Edward E Pryor Jr,Michael C Wiener
Brandon R Goblirsch
Ste24 enzymes, a family of eukaryotic integral membrane proteins, are zinc metalloproteases (ZMPs) originally characterized as "CAAX proteases" targeting prenylated substrates, including a-factor mating pheromone in yeast and prelamin A in ...
RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain [0.03%]
RMSD分析细菌蛋白FimH的结构鉴定其凝集素结构域的五种构象
Pearl Magala,Rachel E Klevit,Wendy E Thomas et al.
Pearl Magala et al.
FimH is a bacterial adhesin protein located at the tip of Escherichia coli fimbria that functions to adhere bacteria to host cells. Thus, FimH is a critical factor in bacterial infections such as urinary tract infections and is of interest ...
Protein adaptation to high hydrostatic pressure: Computational analysis of the structural proteome [0.03%]
蛋白质对高静水压的适应性：结构蛋白组的计算分析
Samvel Avagyan,Daniel Vasilchuk,George I Makhatadze
Samvel Avagyan
Hydrostatic pressure has a vital role in the biological adaptation of the piezophiles, organisms that live under high hydrostatic pressure. However, the mechanisms by which piezophiles are able to adapt their proteins to high hydrostatic pr...
Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment [0.03%]
同源和异源蛋白质复合物的盲预测：CASP13-CAPRI实验
Marc F Lensink,Guillaume Brysbaert,Nurul Nadzirin et al.
Marc F Lensink et al.
We present the results for CAPRI Round 46, the third joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of 20 targets including 14 homo-oligomers and 6 heterocomplexes. Eight of the homo-oligomer targets and...
Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1 [0.03%]
人源肿瘤蛋白Musashi-2氨基端RNA识别模体1的晶体及溶液结构
Lan Lan,Minli Xing,Maithri Kashipathy et al.
Lan Lan et al.
Musashi-2 (MSI2) belongs to Musashi family of RNA binding proteins (RBP). Like Musashi-1 (MSI1), it is overexpressed in a variety of cancers and is a promising therapeutic target. Both MSI proteins contain two N-terminal RNA recognition mot...
Protein structure prediction assisted with sparse NMR data in CASP13 [0.03%]
借助稀疏的NMR数据辅助的蛋白质结构预测(CASP13)
Davide Sala,Yuanpeng Janet Huang,Casey A Cole et al.
Davide Sala et al.
CASP13 has investigated the impact of sparse NMR data on the accuracy of protein structure prediction. NOESY and 15 N-1 H residual dipolar coupling data, typical of that obtained for 15 N,13 C-enriched, perdeuterated proteins up to about 40...