Uncovering Sequence and Structural Characteristics of Fungal Expansin-Related Proteins With Potential to Drive Substrate Targeting [0.03%]
具有靶向底物潜力的真菌扩张相关蛋白的序列和结构特征研究
Anna Pohto,Taru Koitto,Deepika Dahiya et al.
Anna Pohto et al.
Expansins loosen plant cell wall networks through disrupting non-covalent bonds between cellulose microfibrils and matrix polysaccharides. Whereas expansins were first discovered in plants, expansin-related proteins have since been identifi...
Ligand Binding Prediction on Pharmaceutical and Nucleic Acid Targets by the CoDock Group in CASP16 [0.03%]
中国科学院蛋白质科学研究平台蛋白设施在第十三届关键评估中的配体结合预测成果
Ren Kong,Zunyun Jiang,Xufeng Lu et al.
Ren Kong et al.
Ligand binding prediction is a critical component of structure-based drug design, gaining prominence in Critical Assessment of protein Structure Prediction (CASP) since its introduction in CASP15. In CASP16, the challenges expanded to inclu...
Rationalizing Enhanced Affinity of Engineered T-Cell Receptors in Cancer Immunotherapy Through Interaction Energy Calculations and Residue Correlation Analysis [0.03%]
基于相互作用自由能计算和残基相关性分析理性设计肿瘤免疫治疗中工程T细胞受体的亲和力
Mario Frezzini,Daniele Narzi
Mario Frezzini
The advancement of T cell engineering has significantly transformed the field of cancer immunotherapy. In particular, T cells equipped with modified T cell receptors present a promising therapeutic strategy, especially for addressing solid ...
The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα-Fold Arrangement [0.03%]
人类运输和高尔基体组织2同系物(TANGO2)蛋白的晶体结构显示其具有αββα折叠构型
Anne Cooper,Alyssa Powers,Kevin P Battaile et al.
Anne Cooper et al.
Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi-systemic abnormalities and significant phenotypic variability including neurodevelopmental d...
Structural and Enzymological Characterization of Phosphoserine Phosphatase From Brucella melitensis [0.03%]
布鲁氏菌磷丝氨酸磷酸酶的结构与酶学研究
Tanguy Scaillet,Élise Pierson,Marianne Fillet et al.
Tanguy Scaillet et al.
Amino acid L-serine (L-Ser) is a precursor of various biomolecules, including other amino acids, glutathione, and nucleotides. The metabolism of this amino acid is crucial in diseases such as brucellosis. Previous studies have revealed that...
Responses to Ligand Binding in the Bacterial DNA Sliding Clamp "β-Clamp" Manifest in Dynamic Allosteric Effects [0.03%]
细菌DNA滑动夹具"β-钳"对配体结合的反应表现为动态别构效应
Signe Simonsen,Andreas Prestel,Eva C Østerlund et al.
Signe Simonsen et al.
The homo-dimeric, ring-shaped bacterial DNA sliding clamp, β-clamp, is a central hub in DNA replication and repair. It interacts with a plethora of proteins via their short linear motifs, binding to the same hydrophobic binding pocket on ...
Structural Variability of Pfam Domains Based on Alphafold2 Predictions [0.03%]
基于AlphaFold2预测的Pfam家族结构变异分析
Elly Poretsky,Carson M Andorf,Taner Z Sen
Elly Poretsky
Understanding the biological functions of proteins is one of the main goals of functional genomics. Such understanding will help control and manipulate biological processes to enhance desirable traits, including improved abiotic and biotic ...
The SIRT1 N-Terminal Domain as a Common Binding Interface for PPARγ Anchoring [0.03%]
SIRT1的N端结构域作为PPARγ结合的通用界面
Caique Camargo Malospirito,Gabriel Ernesto Jara,Víctor Ulian Antunes et al.
Caique Camargo Malospirito et al.
Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Prolifer...
Biomolecular Interaction Prediction in the Pre- and Post-AlphaFold Era: The 8th CAPRI Evaluation [0.03%]
AlphaFold时代之前与之后的生物分子互作预测：CAPRI评估第八期
Marc F Lensink,Nessim Raouraoua,Guillaume Brysbaert et al.
Marc F Lensink et al.
We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID-related Rounds), which have witnessed the transition to AI-driven prediction tools such as AlphaFold and related a...
Supervised Learning of Protein Melting Temperature: Cross-Species vs. Species-Specific Prediction [0.03%]
基于监督学习的蛋白质熔解温度预测：跨物种与特定物种的对比
Sebastián García López,Jesper Salomon,Wouter Boomsma
Sebastián García López
Protein melting temperatures are important proxies for stability, and frequently probed in protein engineering campaigns, for instance for enzyme discovery and protein optimization. With the emergence of large datasets of melting temperatur...