BioMatics 1.0: A Wasserstein Distance Approach for Next-Generation Multiple Sequence Alignment [0.03%]
BioMatics 1.0：下一代多重序列比对的瓦瑟斯特距离方法
Orkid Coskuner-Weber,Yusuf Emre Ari,Yildiray Efe Berberoglu et al.
Orkid Coskuner-Weber et al.
Accurate multiple sequence alignment (MSA) is central to understanding protein evolution, structure, and function. We present BioMatics 1.0, a novel MSA algorithm that applies optimal transport principles through the Wasserstein first-order...
Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis [0.03%]
一种新的抗侵袭性念珠菌病疫苗候选药物：工程化的HSP90-MP65二价融合抗原
Leszek Wawiórka
Leszek Wawiórka
Invasive candidiasis represents a critical global health challenge, causing approximately 6.5 million bloodstream infections annually with mortality rates exceeding 60%. The emergence of multidrug-resistant Candida strains necessitates nove...
Thomas Gaillard
Thomas Gaillard
Computational protein design (CPD) aims to conceive new proteins or modify existing ones to achieve a functional or structural goal, using numerical methods. Among the various branches of CPD, one consists in predicting sequences given a pr...
Review
Proteins. 2026 Jun 15. DOI:10.1002/prot.70147 2026
Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides [0.03%]
稳定型渗透调节物对人和大鼠胰岛淀粉样多肽构象动力学的影响
Kiara A Kidman,Claudio Pedrick,Cara A Kreck et al.
Kiara A Kidman et al.
The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β-cell dysfunction. In contrast, rat IAPP (rIAPP) is largely no...
Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition [0.03%]
生理pH下骨形态发生蛋白-2的稳定化：CHAPS和精氨酸在聚集抑制中的不同作用
Hirah Amir,Baibhabshri Roy,Aditi Gaur et al.
Hirah Amir et al.
Bone morphogenetic protein-2 (BMP-2) is a key osteoinductive growth factor employed clinically in spinal fusion and fracture repair where bone regeneration is insufficient. However, its therapeutic efficacy is limited by low solubility and ...
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase [0.03%]
解码利什曼原塘菌腺苷磺酸裂解酶功能的结构洞察
Ivan R E Silva,Monique Mantovani,Maria E S D Lino et al.
Ivan R E Silva et al.
One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzy...
Generalizing the Gaussian Network Model: Spanning-Tree Thermodynamics Shows Entropy-Driven KRAS Activation [0.03%]
广义高斯网络模型： spanning-树系综表明熵驱动KRAS激活
Fatma Senguler Ciftci,Burak Erman
Fatma Senguler Ciftci
The GTPase KRAS executes a conformational switch between a GTP-bound active state and a GDP-bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue-contact orga...
Structural Basis for Single-Site Cleavage of Lactoferrin by Diverse Proteases for Prolonged Antibacterial Action: Structure of the Chymotrypsin-Cleaved Lactoferrin C-Lobe [0.03%]
天冬氨酸蛋白酶和胰凝乳蛋白酶切割溶菌酶的单个位点的结构基础：胰凝乳蛋白酶切割的溶菌酶C-lobe的结构
Surabhi Pandit,Nabeel Ahmad,Pradeep Sharma et al.
Surabhi Pandit et al.
The stable lactoferrin C-lobe offers strong potential for therapeutic applications as an antibacterial agent. Lactoferrin is a 78 kDa (Ala1Arg689) iron-binding glycoprotein which is composed of two homologous N- and C-lobes, connected by an...
Universal and Lineage-Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms [0.03%]
ECOD家族在超界和谱系中的分布规律
Rui Guo,Jimin Pei,Jing Zhang et al.
Rui Guo et al.
Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly reso...
Ankh-Score Produces Better Sequence Alignments Than AlphaFold3 [0.03%]
Ankh-Score生成的序列比对优于AlphaFold3
Julia Malec,Karina Rusen,G Brian Golding et al.
Julia Malec et al.
Protein sequence alignment is one of the most fundamental procedures in bioinformatics. Due to its many downstream applications, improvements to this procedure are of great importance. We consider two revolutionary concepts that emerged rec...