SPOP Mutations in Veterans With Prostate Cancer and Outcomes With Doublet and Triplet Therapy in De Novo Metastatic Hormone Sensitive Prostate Cancer [0.03%]
前列腺癌退伍军人中SPOP突变和初诊转移性雄激素敏感性前列腺癌伴双重疗法及三联疗法的结果研究
Joseph J Park,Chin-Lin Tseng,Alexandros Giagtzis et al.
Joseph J Park et al.
Background: Inactivating missense mutations in the tumor suppressor gene speckle-type pox virus and zinc finger protein (SPOP) occur in 5%-15% of men with prostate cancer (PC). SPOP mutations increase androgen receptor-me...
Real-World Comparison of Triplet Versus Doublet Therapy in Japanese Patients With High-Volume Metastatic Hormone-Sensitive Prostate Cancer: A Propensity-Weighted Analysis From the YUSHIMA Registry and Exploratory Bayesian Evidence Synthesis [0.03%]
日本YUSHIMA登记数据库中高容量转移性雄激素敏感前列腺癌患者三联疗法与二联疗法的现实世界比较：倾向加权分析和探索性贝叶斯证据综合
Yosuke Yasuda,Soichiro Yoshida,Shugo Yajima et al.
Yosuke Yasuda et al.
Background: To compare the effectiveness of triplet versus doublet therapy for time to castration-resistant prostate cancer (CRPC) in Japanese patients with high-volume metastatic hormone-sensitive prostate cancer and exa...
Exploring the Gut-Prostate Axis: Microbial Signatures Linked to Prostate Volume and Bladder Function [0.03%]
探究肠-前列腺轴：与前列腺体积和膀胱功能相关的微生物标志物
Jonathan Surber,Marie Lork,Yasser Morsy et al.
Jonathan Surber et al.
Background: Benign prostatic hyperplasia (BPH) is a common urologic condition in aging men, often linked to systemic inflammation and metabolic dysfunction. Emerging evidence suggests that the gut microbiome may contribut...
The Prognostic Significance of Radiographic Progression Without PSA Progression in Patients With Metastatic Hormone-Sensitive Prostate Cancer Treated With First-Line ARPI Therapy [0.03%]
转移性激素敏感性前列腺癌患者一线ARPI治疗后出现影像学进展但PSA无进展的预后意义研究
Takeshi Tsutsumi,Shogo Yamazaki,Takuya Matsuda et al.
Takeshi Tsutsumi et al.
Background: Radiographic progression (RP) without prostate-specific antigen (PSA) elevation has emerged as a clinically important pattern in the androgen receptor pathway inhibitors (ARPI) era, but its prevalence and prog...
A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP-00) [0.03%]
关于重新定位普唑嗪改善前列腺癌患者放疗效果的可行性研究（MiniRaP-00）
Liam D King,David Christie,Daniel Cehic et al.
Liam D King et al.
Background: Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1-adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial prese...
Exosomal ZFPL1 Identifies Neuroendocrine and Stem Cell-Like Prostate Cancer Subtypes? [0.03%]
外泌体ZFPL1识别神经内分泌和干细胞样前列腺癌亚型？
Neshat Masud,Johnmesha Sanders,Kenneth A Iczkowski et al.
Neshat Masud et al.
Background: Calcitonin (CT) and its receptor promote prostate cancer (PC) progression and metastasis. Identifying downstream CT-regulated genes may provide clinically useful biomarkers. ...
A Pilot Study of 18F-rhPSMA-7.3-PET/MRI to Reduce Mischaracterization of Active Surveillance and Focal Therapy Candidates With Occult Higher Risk Disease [0.03%]
18F-rhPSMA-7.3-PET/MRI阴性前列腺癌患者中隐匿高危病灶的试点研究
Ridwan Alam,Derek Hesse,Nikki Hubbard et al.
Ridwan Alam et al.
Introduction: PSMA-PET offers an opportunity to reduce the mischaracterization of disease in active surveillance (AS) and focal therapy (FT) candidates. We describe the results of a pilot clinical trial evaluating 18F-rad...
Does Insulin Resistance Predict Lower Urinary Tract Symptoms? Results From the Reduction by Dutasteride of Prostate Cancer (REDUCE) Trial [0.03%]
胰岛素抵抗能否预测下尿路症状？来自减少前列腺癌DUTA试验的结果
Renning Zheng,James P Daniels,James M Mirocha et al.
Renning Zheng et al.
Background: We previously found that higher insulin resistance (IR) was associated with larger prostate size and greater risk of benign prostatic hyperplasia (BPH). Since BPH is the most common cause of lower urinary trac...
Association Between Preoperative Membranous Urethral Length and Urinary Continence Recovery After Retzius Sparing Robotic Assisted Radical Prostatectomy: Results From a Retrospective Single-Center Study [0.03%]
保留Retzius筋膜的机器人辅助根治性前列腺切除术中尿控功能恢复与尿道长度之间的关系：一项回顾性单中心研究结果
Konstantinos Pagonis,Mohamed Noureldin,Eddy Lilly et al.
Konstantinos Pagonis et al.
Background: Urinary incontinence (UI) remains a common complication after radical prostatectomy, even with advancements such as robotic-assisted radical prostatectomy (RARP). Preoperative membranous urethral length (MUL) ...
Surveillance Versus Treatment for Favorable Intermediate-Risk Prostate Cancer and Mortality-Risk [0.03%]
中危有利前列腺癌的监测与治疗及死亡风险的关系
Mutlay Sayan,Yetkin Tuac,Zhiyu Qian et al.
Mutlay Sayan et al.
Background: Active surveillance (AS) is the preferred management approach for patients with low-risk prostate cancer (PC); yet whether younger patients with favorable-intermediate-risk (FIR) PC experience increased mortal...