A Gene Expression Tumor Signature Optimizing Partial Area-Under-the-Curve (pAUC) to Improve Specificity for Indolent Prostate Cancer [0.03%]
Travis A Gerke,Svitlana Tyekucheva,Konrad H Stopsack et al.
Travis A Gerke et al.
Purpose: A key clinical challenge in prostate cancer is the identification and validation of biomarkers with high specificity for indolent long-term outcomes. We applied a novel statistical method to identify tumor transc...
Brian T Helfand,Zhuqing Shi,Ashley J Mulford et al.
Brian T Helfand et al.
Background: Chronic nonurological complications are common among prostate cancer (PCa) survivors; however, their spectrum, magnitude, and genetic contribution remain poorly characterized. ...
The Clinical Significance of Gallium-68 PSMA-11 PET-Derived SUVmax in the Management of Metastatic Hormone-Sensitive Prostate Cancer [0.03%]
68镓PSMA-11 PET最大标准摄取值在转移性激素敏感型前列腺癌管理中的临床意义
Cevat İlteriş Kıkılı,Caner Kapar,Feyyaz Hazar Yağmur et al.
Cevat İlteriş Kıkılı et al.
Purpose: Previous studies have demonstrated an association between PSMA-PET SUVmax and poorer survival outcomes in patients with mCRPC. However, limited data are available in mHSPC. We aim to investigate the relationship ...
Human Epidermal Growth Factor Receptor 2 Expression in Prostatic Carcinomas: A Systematic Review and Meta-Analysis of a Potential Therapeutic Target [0.03%]
人表皮生长因子受体2在前列腺癌中的表达：可能的治疗靶点系统评价和 meta 分析
Jacky T F Luk,Alex H Lin,Esther K C Cheung et al.
Jacky T F Luk et al.
Introduction: The clinical relevance of HER2 expression profile in solid cancers has expanded with the evolving landscape of HER2 targeting agents. This systematic review and meta-analysis aim to detail the prevalence of ...
Impact of the Nadir Androgen Receptor Signaling Inhibitor-Derived Integrative Response Model in Real-World Patients With Metastatic Castration-Sensitive Prostate Cancer [0.03%]
去势敏感性转移性前列腺癌真实世界患者的恩扎卢胺衍生整合反应模型的预测效果评估研究
Kazuma Yukihiro,Yohei Sekino,Keisuke Goto et al.
Kazuma Yukihiro et al.
Background: Early deep prostate-specific antigen (PSA) decline after the initiation of androgen receptor signaling inhibitor (ARSI) therapy is associated with favorable long-term outcomes in metastatic castration-sensitiv...
Safety and Efficacy of Bipolar Transurethral Vaporization of the Prostate and Bipolar Transurethral Resection of the Prostate in the Management of Large Volume Benign Prostatic Hyperplasia: A Prospective Randomized Study [0.03%]
经尿道双极汽化术与经尿道双极切除术治疗大体积良性前列腺增生的疗效分析：前瞻性随机研究
Amr M Lotfy,Maged Mostafa Kamel,Mahmoud Abdallah et al.
Amr M Lotfy et al.
Purpose: The aim of the study was to compare the functional and sexual outcomes of bipolar transurethral vaporization of the prostate (TUVP) and bipolar transurethral resection of the prostate (TURP) in patients with infr...
Assessment of Circulating Neuroendocrine Tumor Markers at Prostate Cancer Diagnosis: An Investigation of Prostate Cancer With Neuroendocrine Features [0.03%]
前列腺癌诊断时循环神经内分泌肿瘤标志物的评估：一项具有神经内分泌特征的前列腺癌调查研究
Tatsuya Shimomura,Masaya Murakami,Kanako Kasai et al.
Tatsuya Shimomura et al.
Background: Neuroendocrine prostate cancer (NEPC) is characterized by its aggressive biological behavior and poor prognosis, distinguishing it from prostate adenocarcinoma. Although several studies have investigated tumor...
Protein Kinase D1 Translocates PARP1 to the Membrane and Is Associated With Increased Sensitivity to Cell Viability Inhibition by PARP1 Inhibitor Olaparib [0.03%]
蛋白激酶D1将PARP1转位至细胞膜并与其协同作用增强奥拉帕尼对细胞存活的抑制作用
Sanjeev Shukla,Joseph McGrath,Robert Willis et al.
Sanjeev Shukla et al.
Background: There are four FDA-approved poly (ADP-ribose) polymerase inhibitors (PARPi) for treating metastatic castration-resistant prostate cancer. However, dose-limiting toxicities may reduce efficacy when treatment is...
Second Therapeutic Freeze After Salvage Cryoablation for Localized Radiorecurrent Prostate Cancer [0.03%]
局部放疗后复发前列腺癌挽救性冷冻消融后的第二次治疗冷冻疗法
Sudharshanan Balaji,Mahdi Mottaghi,Paul P Koffer et al.
Sudharshanan Balaji et al.
Objective: To report long-term oncologic and functional outcomes of a second therapeutic freeze (STF) after salvage cryoablation (sCryo) for biopsy-proven persistence following radiotherapy for localized prostate cancer. ...
Sheila Jonnatan,Luka Cavka,Angelo M De Marzo et al.
Sheila Jonnatan et al.
Background: Prostate cancer can be an indolent disease with which patients can live for many years. Thus, an understanding of how therapy and its ensuing resistance affect prostate cancer kinetics may guide efforts to det...