Lipid and Foam Cell Accumulation as Novel Pathological Features of Benign Prostatic Hyperplasia [0.03%]
脂质和泡沫细胞聚集物为良性前列腺增生的新型病理特征
Dita Julianingsih,Samara V Silver,Thaissa Horne et al.
Dita Julianingsih et al.
Background: Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance-induced lower u...
Outcome Differences Between Subgroups of Favorable Intermediate Risk Prostate Cancer After Radical Prostatectomy [0.03%]
根治术后有利中危前列腺癌不同亚组的结局差异
Matthew T Steidle,Kamil Malshy,Zijing Cheng et al.
Matthew T Steidle et al.
Objective: Grade Group (GG) 1 disease is known to have low metastatic potential, but in the D'Amico risk stratification systems a GG1 tumor with prostate-specific antigen (PSA) of 10-20 ng/mL qualifies as intermediate ris...
Letter to the Editor Regarding "Challenging the Evolving Nomenclature of Ultrasound-Guided Transperineal Prostate Biopsy: A Call for Standardization" [0.03%]
关于“挑战超声引导经会阴前列腺活检术术语的演变：呼吁规范化”的来信
Eriz Özden,Erdem Öztürk,İsa Dağlı
Eriz Özden
Establishment and Characterization of Patient-Derived Xenograft Organoids for Personalized Treatment of Castration-Resistant Prostate Cancer [0.03%]
用于前列腺癌个性化治疗的患者源性异种移植类器官的建立与鉴定
Takuro Sunada,Yuki Kamiyama,Maki Fujiwara et al.
Takuro Sunada et al.
Background: Basic research on castration-resistant prostate cancer (CRPC) is limited by the lack of clinically relevant models. This study aimed to establish patient-derived xenografts (PDX) and PDX-derived organoids from...
Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome [0.03%]
表观遗传调控慢性前列腺炎/慢性骨盆疼痛综合征免疫功能紊乱的研究
Praveen Thumbikat,Goutham Pattabiraman,Farzaneh Sharifzad et al.
Praveen Thumbikat et al.
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms und...
Non-Cancer Causes of Death in Patients With Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Analysis [0.03%]
转移性激素敏感型前列腺癌患者非癌症死因分析：一项真实世界研究
Marta Garcia de Herreros,Clara Rodrigo,Laura Ferrer-Mileo et al.
Marta Garcia de Herreros et al.
Background: As overall survival improves in metastatic hormone-sensitive prostate cancer (mHSPC), non-cancer causes of death are increasingly relevant. Me...
Temporal Patterns and Resolution of Toxicities Following Hypofractionated Salvage Radiotherapy for Biochemical Recurrence of Prostate Cancer After Prostatectomy [0.03%]
前列腺切除术后生化复发前列腺癌患者的挽救性超分割放疗的毒性时间模式及缓解情况
Bum-Sup Jang,Seok-Joo Chun,Jin Ho Kim
Bum-Sup Jang
Background: Hypofractionated salvage radiotherapy is increasingly used for biochemical recurrence of prostate cancer post-prostatectomy, yet its toxicity profile remains underexplored. This study evaluates the incidence, ...
Perioperative Safety and Early Oncologic Outcomes of Salvage Irreversible Electroporation for Radiorecurrent Prostate Cancer [0.03%]
挽救性不可逆电穿孔治疗放射性前列腺癌的围手术期安全性和早期肿瘤学结果
Jarrett Noakes,Katherine Wainwright,Elias Hyams
Jarrett Noakes
Background: Local recurrence after definitive radiotherapy for prostate cancer (PCa) remains a challenging clinical problem. Salvage irreversible electroporation (sIRE) is a non-thermal focal ablation approach with limite...
Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer [0.03%]
基因组突变对局部早期前列腺癌转录通路和肿瘤微环境景观的影响
William Lautert-Dutra,Camila M Melo,Luiz P Chaves et al.
William Lautert-Dutra et al.
Background: The management of intermediate-risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alter...