Hematological Inflammation Markers in the Prediction of Clinically Significant Prostate Cancer and the Individualization of Biopsy Decisions for PI-RADS 3 Lesions: A Two-Center Retrospective Study [0.03%]
血液炎症标志物在预测临床显著性前列腺癌及个体化PI-RADS 3病变活检决策中的作用：一项两中心回顾性研究
Ali Eroglu,Cem Tugrul Gezmis,Yusuf Arikan et al.
Ali Eroglu et al.
Background: PI-RADS 3 lesions represent a diagnostic "gray zone" in which biopsy decision-making is particularly challenging, with reported clinically significant prostate cancer (csPCa) detection rates ranging from 13% t...
Enhancing Continence Recovery After Robot-Assisted Radical Prostatectomy: A Novel Combined Approach Using Testosterone Therapy and Magnetic Stimulation [0.03%]
机器人辅助根治性前列腺切除术后控便功能恢复的改善：一种新的睾酮治疗和磁刺激联合方案
Yasunari Tanaka,Fumitaka Shimizu,Abulaiti Abudurezake et al.
Yasunari Tanaka et al.
Background: Urinary incontinence (UI) may persist in some patients after robot-assisted radical prostatectomy (RARP), significantly affecting quality of life (QOL). This study investigated the changes in UI and pelvic flo...
Comprehensive Characterization of Metastatic Patterns and a Redefined Prognostic Framework in Metastatic Prostate Cancer [0.03%]
转移性前列腺癌的全面特征刻画及预后体系的重新定义
Shiqiang Zhang,Yiyu Sheng,Yiran Wang et al.
Shiqiang Zhang et al.
Background: Metastatic prostate cancer (mPCa) exhibits highly complex metastatic patterns. Comprehensive evaluation of distinct metastatic patterns and their integrated prognostic impact remains lacking. ...
Real-World Clinical Evaluation of S2,3PSA Test in a Prostate Biopsy Cohort With PSA Level of 4-10 ng/mL [0.03%]
前列腺特异性抗原(S2,3PSA)检测在前列腺活检指征人群中的临床应用价值研究
Jun Furumido,Sho Nonoyama,Chika Hoshi (Hosokawa) et al.
Jun Furumido et al.
Background: Prostate-specific antigen (PSA) is a widely used prostate cancer marker; however, its use is limited by its low specificity. Novel biomarkers are being explored to avoid unnecessary biopsies. A new prostate ca...
Outcomes of Patients With Favorable Intermediate Risk Gleason Grade Group 2 Prostate Cancer Undergoing Radical Prostatectomy in the MRI Era: Refining Active Surveillance Selection Criteria [0.03%]
MRI时代下分期有利于中间风险的格莱森分级组2期前列腺癌患者行根治性前列腺切除术的效果：优化积极监测选择标准
Eric V Li,Eman E Ahmed,Mohamed E Ahmed et al.
Eric V Li et al.
Background: While guidelines state that patients with NCCN favorable intermediate risk (FIR) prostate cancer (PCa) may consider active surveillance (AS), there is a relative lack of longer term follow up data informing AS...
Microbial Differences in Prostate Lesions Between Black and White American Men [0.03%]
美国男性中前列腺病变的微生物差异：黑白人种对比研究
Shiv Verma,Karishma Gupta,Xi Qiao et al.
Shiv Verma et al.
Background: Ethnicity and pathological factors contribute to differences in prostate neoplasm, and this landscape could be influenced by the local microbiome. ...
Spatial Distribution of Prostate Cancer Missed by MRI-Targeted Biopsy, Effect of a Perilesional Template, and Restaging in a Radical Prostatectomy Cohort [0.03%]
前列腺癌磁共振靶向活检漏诊的分布、周围模板的影响以及根治性前列腺切除术队列中的分期评估
Ruth Himmelsbach,Julia Franz,Cordula Jilg et al.
Ruth Himmelsbach et al.
Purpose: Systematic biopsy (SB) remains recommended in addition to MRI-targeted biopsy (TB) because TB alone may miss clinically significant prostate cancer (sPC). We evaluated the spatial distribution of sPC and clinical...
Efficacy, Safety, and Cost-Effectiveness of Reduced versus Full Initial Doses of Androgen Receptor Signaling Inhibitors in Non-Metastatic Castration-Resistant Prostate Cancer: A Multicenter Retrospective Study [0.03%]
减剂量与全剂量雄激素受体信号传导抑制剂治疗非转移性去势抵抗性前列腺癌的疗效、安全性和成本效益：多中心回顾性研究
Himawari Asanuma,Naoki Fujita,Shumon Kato et al.
Himawari Asanuma et al.
Background: The introduction of novel androgen receptor signaling inhibitors (ARSIs) has substantially transformed the systemic treatment landscape for non-metastatic castration-resistant prostate cancer (nmCRPC). Unfortu...
Characterizing the Activity of Inflammasome-Related Genes and Their Association With Oncological Outcomes in Prostate Cancer [0.03%]
前列腺癌中炎症小体相关基因的表达特征及其与临床结局的关系
Alireza Ghoreifi,Mohammed Alshalalfa,Elai Davicioni et al.
Alireza Ghoreifi et al.
Background: Inflammation plays a critical role in cancer cell proliferation; however, the specific role of inflammasomes, multiprotein complexes that regulate inflammation-associated signaling pathways, in prostate cancer...
Prognostic Role of Serum Neuron-Specific Enolase at Baseline and its Early Dynamics in Metastatic Castration-Resistant Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors [0.03%]
基线及早期动力学神经元特异性烯醇化酶在雄激素受体信号抑制剂治疗转移性去势抵抗性前列腺癌中的预后价值
Ondřej Fiala,Michaela Tkadlecová,Zuzana Váchalová et al.
Ondřej Fiala et al.
Background: Outcomes of metastatic castration-resistant prostate cancer (mCRPC) treated with androgen receptor signaling inhibitors (ARSIs) vary widely and may not be fully reflected by PSA and standard clinicopathologic ...