Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis [0.03%]
成纤维细胞特异性的整合素αv调控类型17和类型2驱动的炎症及纤维化
Joshua C Sciurba,Richard L Gieseck,Nikhil Jiwrajka et al.
Joshua C Sciurba et al.
Fibroproliferative diseases affect a significant proportion of the world's population. Despite this, core mechanisms driving organ fibrosis of diverse etiologies remain ill defined. Recent studies suggest that integrin-alpha V serves as a m...
Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia [0.03%]
干扰素-γ直接诱导胃上皮细胞死亡并促进肠上皮化生的发展
Luciana H Osaki,Kevin A Bockerstett,Chun F Wong et al.
Luciana H Osaki et al.
Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern ma...
Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities [0.03%]
黑色素瘤亚型：基因组谱型、预后分子标志物及治疗可能性
Roy Rabbie,Peter Ferguson,Christian Molina-Aguilar et al.
Roy Rabbie et al.
Melanoma is characterised by its ability to metastasise at early stages of tumour development. Current clinico-pathologic staging based on the American Joint Committee on Cancer criteria is used to guide surveillance and management in early...
Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis [0.03%]
动脉粥样血栓形成过程中巨噬细胞、肥大细胞、嗜酸性粒细胞和中性粒细胞产生的胞外诱捕网呈时间依赖性生成
Kartika R Pertiwi,Onno J de Boer,Claire Mackaaij et al.
Kartika R Pertiwi et al.
Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory cell types in coronary atherosclerotic plaque or thrombus also release extracell...
Svenja Loering,Guy J M Cameron,Malcolm R Starkey et al.
Svenja Loering et al.
Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into early adulthood. The process can be separated into five ...
Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations [0.03%]
边缘区B细胞淋巴增生性疾病免疫球蛋白基因库的特征分析
Aliki Xochelli,Vasilis Bikos,Eleftheria Polychronidou et al.
Aliki Xochelli et al.
The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. s...
High expression of CCR5 in melanoma enhances epithelial-mesenchymal transition and metastasis via TGFβ1 [0.03%]
高表达CCR5通过TGFβ1增强黑色素瘤的上皮间质转化和转移能力
Jie Liu,Caihong Wang,Xuhui Ma et al.
Jie Liu et al.
Chemokine receptors are highly expressed in various cancers and play crucial roles in tumor progression. However, their expression patterns and functions in melanoma are unclear. The present study aimed to identify the chemokine receptors t...
What's in a name? Molecular subclassification of sarcomas creates fresh challenges [0.03%]
分子亚型分类使软组织肉瘤的诊断和治疗面临新挑战
Juan Díaz-Martín,Michele Biscuola,Jonatan Benoit et al.
Juan Díaz-Martín et al.
This commentary addresses the issue of the classification of sarcomas in the article written by Watson and colleagues published recently in this journal. The article delves into the molecular characterization and distinct phenotypes of some...
Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia [0.03%]
肠型胃粘膜内新生物的初始和关键基因事件
Hirofumi Rokutan,Hiroyuki Abe,Hiromi Nakamura et al.
Hirofumi Rokutan et al.
Gastric cancer (GC) is one of the most common and life-threatening malignancies. The course of disease and tumor aggressiveness vary among GCs, although how early fate is determined and by what factors remains elusive. To solve this questio...
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis [0.03%]
小胶质细胞CD40信号驱动自身免疫性脑脊髓炎的发展
Suzanne Abm Aarts,Tom Tp Seijkens,Pascal Jh Kusters et al.
Suzanne Abm Aarts et al.
The costimulatory CD40L-CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expressed on MHCII+ B cells, dendritic cells and macrophages in human MS lesions. Here we investigated the role of the CD40 downstream signaling...