New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis [0.03%]
新酒装旧皮囊：PGC-1α和NF-κB在肥胖症和急性胰腺炎中的作用
Kalliope N Diakopoulos,Hana Algül
Kalliope N Diakopoulos
Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connect...
LKB1 signaling is activated in CTNNB1-mutated HCC and positively regulates β-catenin-dependent CTNNB1-mutated HCC [0.03%]
CTNNB1突变的肝癌中LKB1信号被激活并正向调控β-catenin依赖性的CTNNB1突变的HCC生长
Sara Charawi,Pierre-Alexandre Just,Mathilde Savall et al.
Sara Charawi et al.
Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β-catenin (CTNNB1-mutated HCC), constitute a very ho...
MicroRNA-374b induces endothelial-to-mesenchymal transition and early lesion formation through the inhibition of MAPK7 signaling [0.03%]
微小核糖核酸374b通过抑制MAPK7信号诱导内皮细胞向间充质细胞转化和早期病灶形成
Byambasuren Vanchin,Emma Offringa,Julian Friedrich et al.
Byambasuren Vanchin et al.
Endothelial-mesenchymal transition occurs during intimal hyperplasia and neointima formation via mechanisms that are incompletely understood. Endothelial MAPK7 signaling is a key mechanosensitive factor that protects against endothelial-mes...
A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1 [0.03%]
一种新的年龄相关性静脉淀粉样变性来源于含表皮生长因子纤维蛋白原样细胞外基质蛋白1
Masayoshi Tasaki,Mitsuharu Ueda,Yoshinobu Hoshii et al.
Masayoshi Tasaki et al.
Most intractable tissue-degenerative disorders share a common pathogenic condition, so-called proteinopathy. Amyloid-related disorders are the most common proteinopathies and are characterized by amyloid fibril deposits in the brain or othe...
Case Reports
The Journal of pathology. 2019 Apr;247(4):444-455. DOI:10.1002/path.5203 2019
shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth [0.03%]
人胶质瘤干细胞中由shRNA介导的PPARα敲低可降低其在体外的增殖并抑制原位异种移植物肿瘤生长
Harry R Haynes,Helen L Scott,Clare L Killick-Cole et al.
Harry R Haynes et al.
The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcri...
Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions [0.03%]
卵巢癌前病变的基因组景观和进化轨迹
Ren-Chin Wu,Pei Wang,Shiou-Fu Lin et al.
Ren-Chin Wu et al.
The clonal relationship between ovarian high-grade serous carcinoma (HGSC) and its presumed precursor lesion, serous tubal intraepithelial carcinoma (STIC), has been reported. However, when analyzing patients with concurrent ovarian carcino...
More expression, less function: cleaved dynamin in glomerular kidney disease [0.03%]
更表达，少功能：肾小球肾脏病中的分裂动力蛋白
Mehmet M Altintas,Jochen Reiser
Mehmet M Altintas
The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes (FPs). Destruction of dynamin, for example by ca...
Silvio R Podmirseg,Jonathan Vosper,Ludger Hengst
Silvio R Podmirseg
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non-small cell lung carcinoma (NSCLC) subtype accounting for the majority of cases. Therefore, an urgent need exists for a more detailed dissection ...
Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone [0.03%]
MAPK信号通路的激活突变定义了骨纤维结构不良
Daniel Baumhoer,Michal Kovac,Jan Sperveslage et al.
Daniel Baumhoer et al.
Non-ossifying fibroma (NOF), which occasionally results in pathologic fracture, is considered the most common benign and self-limiting lesion of the growing skeleton. By DNA sequencing we have identified hotspot KRAS, FGFR1 and NF1 mutation...
Multicenter Study
The Journal of pathology. 2019 May;248(1):116-122. DOI:10.1002/path.5216 2019