The innate immune architecture of lung tumors and its implication in disease progression [0.03%]
肺肿瘤的先天免疫架构及其在疾病进展中的作用
Simon Milette,Pierre O Fiset,Logan A Walsh et al.
Simon Milette et al.
Lung malignancies are the leading cause of cancer-related mortality. By virtue of its unique physiological function, the lung microenvironment is highly dynamic and constantly subjected to mechanical, chemical and pathogenic stimuli. Thus, ...
Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells [0.03%]
丙型肝炎病毒感染诱导人胎儿肝脏干细胞内质网应激及细胞凋亡
Xuan Guo,Wei-Li Liu,Dong Yang et al.
Xuan Guo et al.
The cellular mechanisms by which hepatitis C virus (HCV) replication might mediate cytopathic effects are controversial and not entirely clear. In this study, we found that blood-borne HCV (bbHCV) infection could lead to endoplasmic reticul...
Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma [0.03%]
EB病毒致癌基因LMP1通过调控S1PR2促进弥漫大B细胞淋巴瘤侵袭性的分子机制研究
Martina Vockerodt,Katerina Vrzalikova,Maha Ibrahim et al.
Martina Vockerodt et al.
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B-cell (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), yet its contribution to this tumour remains poorly understood. We have focused on the EBV-encoded laten...
NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling [0.03%]
NSD2环状RNA通过靶向miR-199b-5p介导的DDR1和JAG1信号促进结直肠癌转移
Liang-Yan Chen,Zheng Zhi,Lian Wang et al.
Liang-Yan Chen et al.
Liver metastasis is the main cause of death in patients with colorectal cancer (CRC). Here, we searched for CRC metastasis-associated circular RNA in a mouse model of liver metastasis of CRC by using RNA (transcriptome)-sequencing. We ident...
Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms [0.03%]
整合微生物学、分子病理学和流行病学：探索微生物驱动性肿瘤发病机制的新范式
Tsuyoshi Hamada,Jonathan A Nowak,Danny A Milner Jr et al.
Tsuyoshi Hamada et al.
Molecular pathological epidemiology (MPE) is an integrative transdisciplinary field that addresses heterogeneous effects of exogenous and endogenous factors (collectively termed 'exposures'), including microorganisms, on disease occurrence ...
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury [0.03%]
中性粒细胞弹性蛋白酶在缺血/再灌注损伤后静脉基底膜重塑和中性粒细胞穿出过程中起非冗余作用
Mathieu-Benoit Voisin,Giovanna Leoni,Abigail Woodfin et al.
Mathieu-Benoit Voisin et al.
Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies, such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated neutrophils se...
TRPV4 is involved in levonorgestrel-induced reduction in oviduct ciliary beating [0.03%]
TRPV4参与左炔诺孕酮诱导的输卵管纤毛摆动减弱作用
Cheng Li,Yan-Ting Wu,Qian Zhu et al.
Cheng Li et al.
Previous studies revealed the increasing risk of tubal pregnancy following failure of levonorgestrel (LNG)-induced emergency contraception, which was attributed to the reduced ciliary motility in response to LNG. However, understanding of t...
MAPK pathway-activating mutations drive giant cell lesions of the jaws and non-ossifying fibromas of bone [0.03%]
激活MAPK通路的突变驱动颌骨巨大细胞病变及骨非成骨性纤维瘤的发展
Carolina C Gomes,Ricardo S Gomez
Carolina C Gomes
Anna C Wilkins,Emmanuel C Patin,Kevin J Harrington et al.
Anna C Wilkins et al.
Historically, our understanding of the cytotoxicity of radiation has centred on tumour cell-autonomous mechanisms of cell death. Here, tumour cell death occurs when a threshold number of radiation-induced non-reparable double-stranded DNA b...