Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy [0.03%]
膀胱癌多区域测序揭示肿瘤进化、膀胱癌表型和靶向治疗意义
Timon Heide,Angela Maurer,Monika Eipel et al.
Timon Heide et al.
We present an evolutionary analysis of the relative time of genetic events underlying tumorigenesis in human bladder cancers from 10 whole cystectomy specimens using multiregional whole-exome sequencing. We timed bladder cancer drivers, mut...
F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function [0.03%]
F盒蛋白FBXO16通过抑制核β-catenin功能发挥肿瘤抑制作用
Debasish Paul,Sehbanul Islam,Rajesh Kumar Manne et al.
Debasish Paul et al.
Aberrant activation of β-catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β-catenin-signaling pathways is still poorly understood. In this study, ...
Plasma Epstein-Barr virus DNA as an archetypal circulating tumour DNA marker [0.03%]
血浆EB病毒DNA作为循环肿瘤DNA标志物的典范
Wai Kei Jacky Lam,Kwan Chee Allen Chan,Yuk Ming Dennis Lo
Wai Kei Jacky Lam
Analysis of circulating tumour DNA (ctDNA), as one type of 'liquid biopsy', has recently attracted great attention. Researchers are exploring many potential applications of liquid biopsy in many different types of cancer. In particular, it ...
RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway [0.03%]
通过调节ERK / MAPK-cyclin D1 / CDK4途径，RN181在胃癌中起抑癌作用
Suihai Wang,Xiaobo Wang,Yanjun Gao et al.
Suihai Wang et al.
RN181, a RING finger domain-containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are obscure. Here, we report that RN181 expression is significantly down-regulated in 16...
Wulf Tonnus,Claudia Meyer,Alexander Paliege et al.
Wulf Tonnus et al.
Necrosis of a cell is defined by the loss of its plasma membrane integrity. Morphologically, necrosis occurs in several forms such as coagulative necrosis, colliquative necrosis, caseating necrosis, fibrinoid necrosis, and others. Biochemic...
Local hyperthyroidism promotes pancreatic acinar cell proliferation during acute pancreatitis [0.03%]
局部甲状腺功能亢进在急性胰腺炎时促进胰腺外分泌细胞增殖
Ermanno Malagola,Rong Chen,Marta Bombardo et al.
Ermanno Malagola et al.
Proliferation of pancreatic acinar cells is a critical process in the pathophysiology of pancreatic diseases, because limited or defective proliferation is associated with organ dysfunction and patient morbidity. In this context, elucidatin...
TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG [0.03%]
TBX3通过诱导上皮间质转化和直接上调SLUG来促进乳腺癌前侵袭性细胞的进展
Milica Krstic,Bart Kolendowski,Matthew J Cecchini et al.
Milica Krstic et al.
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecula...
Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma [0.03%]
肝细胞癌和肝内胆管癌的基因组特征相似性研究
Nancy M Joseph,Christos G Tsokos,Sarah E Umetsu et al.
Nancy M Joseph et al.
Combined hepatocellular-cholangiocarcinomas (CHC) are mixed tumours with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) components. CHC prognosis is similar to intrahepatic CC (ICC) and worse than HCC; staging and treatment...
Comparative Study
The Journal of pathology. 2019 Jun;248(2):164-178. DOI:10.1002/path.5243 2019
Takuto Yoshioka,Akihisa Fukuda,Osamu Araki et al.
Takuto Yoshioka et al.
In the mammalian stomach, the isthmus has been considered as a stem cell zone. However, various locations and proliferative activities of gastric stem cells have been reported. We focused here on the stem cell marker Bmi1, a polycomb group ...
Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury [0.03%]
第2组固有淋巴样细胞在急性肾损伤中的治疗潜力
Guy J M Cameron,Simon H Jiang,Svenja Loering et al.
Guy J M Cameron et al.
Acute kidney injury (AKI) remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an AKI are at increased risk of developing chronic kidney disease and end stage renal failu...