Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder [0.03%]
膀胱倒置移行细胞乳头状瘤和移行细胞乳头状瘤的基因组景观
Sumit Isharwal,Wenhuo Hu,Judy Sarungbam et al.
Sumit Isharwal et al.
Inverted urothelial papilloma (IUP) and urothelial papilloma (UP) are rare urothelial neoplasms that typically follow a benign clinical course. Oncogenic mutations in FGFR3, HRAS, and the TERT promoter have been reported in these entities b...
Ralph H Hruban,Matthias M Gaida,Elizabeth Thompson et al.
Ralph H Hruban et al.
The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be...
Non-ossifying fibroma: A RAS-MAPK driven benign bone neoplasm [0.03%]
非骨化性纤维瘤是一种RAS-MAPK信号途径驱动的良性骨肿瘤
Judith Vmg Bovée,Pancras Cw Hogendoorn
Judith Vmg Bovée
Non-ossifying fibroma (NOF) has been an intriguing entity since its first description. It is the most common bone tumour, is usually asymptomatic affecting children and adolescents, is composed of a heterogeneous cell population, and underg...
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels [0.03%]
与溃疡相关的细胞系表达参与再生的基因，并且其特征是高水平的中性粒细胞明胶酶相关载脂蛋白(NGAL)
Silje Thorsvik,Atle van Beelen Granlund,Tarjei D Svendsen et al.
Silje Thorsvik et al.
Neutrophil gelatinase-associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for IBD. Here we demonst...
Dane Cheasley,Na Li,Simone M Rowley et al.
Dane Cheasley et al.
Breast cancer (BC) diagnosed after a negative mammogram but prior to the next screening episode is termed an 'interval BC' (IBC). Understanding the molecular differences between IBC and screen-detected BCs (SDBC) could improve mammographic ...
Comparative Study
The Journal of pathology. 2019 Jun;248(2):243-252. DOI:10.1002/path.5251 2019
Androgen receptor variant 12 promotes migration and invasion by regulating MYLK in gastric cancer [0.03%]
胃癌中雄激素受体变异体12通过调节MYLK促进转移和侵袭
Nan Xia,Jiantao Cui,Min Zhu et al.
Nan Xia et al.
Androgen receptor (AR) and its variants (AR-Vs) promote tumorigenesis and metastasis in many hormone-related cancers, such as breast, prostate and hepatocellular cancers. However, the expression patterns and underlying molecular mechanisms ...
N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia [0.03%]
tau和MAP1的N-同型半胱氨酸化在阿尔茨海默病和血管性痴呆的尸检标本中增加
Carine Bossenmeyer-Pourié,A David Smith,Sylvain Lehmann et al.
Carine Bossenmeyer-Pourié et al.
The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear. We investigated the homocysteinylation of microtubule-associated proteins (MAPs) i...
Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology [0.03%]
病理学最新进展《2019年病理学杂志年度评论特刊》
C Simon Herrington,Richard Poulsom,Philip J Coates
C Simon Herrington
In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent adv...
L-PGDS-derived PGD2 attenuates acute lung injury by enhancing endothelial barrier formation [0.03%]
由L-PGDS衍生的PGD2通过增强内皮屏障的形成来缓解急性肺损伤
Daiki Horikami,Naoki Toya,Koji Kobayashi et al.
Daiki Horikami et al.
Acute lung injury (ALI) is caused by various stimuli such as acid aspiration and infection, resulting in severe clinical outcomes with high mortality. Prostaglandin D2 (PGD2 ) is a lipid mediator produced in the lungs of patients with ALI. ...