Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma [0.03%]
儿童原发性和转移性骨肉瘤的集成基因组分析
Gian Luca Negri,Bruno M Grande,Alberto Delaidelli et al.
Gian Luca Negri et al.
Despite being the most common childhood bone tumor, the genomic characterization of osteosarcoma remains incomplete. In particular, very few osteosarcoma metastases have been sequenced to date, critical to better understand mechanisms of pr...
Multicenter Study
The Journal of pathology. 2019 Nov;249(3):319-331. DOI:10.1002/path.5319 2019
Carina Bernardo,Pontus Eriksson,Nour-Al-Dain Marzouka et al.
Carina Bernardo et al.
Molecular subtypes of urothelial carcinoma may be divided into luminal and nonluminal tumors. Nonluminal tumors are composed of cases with basal/squamous-like or small cell/neuroendocrine features, with a consensus on the molecular characte...
Gamma-secretase complex-dependent intramembrane proteolysis of CD147 regulates the Notch1 signaling pathway in hepatocellular carcinoma [0.03%]
泛分泌酶复合物介导的CD147内膜蛋白水解调控肝癌中Notch1信号通路
Yu-Le Yong,Ren-Yu Zhang,Ze-Kun Liu et al.
Yu-Le Yong et al.
The γ-secretase complex is a presenilin-dependent aspartyl protease involved in the intramembranous cleavage of various type I transmembrane proteins. As a type I transmembrane protein, CD147 is highly expressed in hepatoma cells and promo...
Development of a predictive model for stromal content in prostate cancer samples to improve signature performance [0.03%]
开发预测前列腺癌样本间质含量的模型以提高标志物性能
Nadia Boufaied,Mandeep Takhar,Claire Nash et al.
Nadia Boufaied et al.
Prostate cancer is heterogeneous in both cellular composition and patient outcome, and development of biomarker signatures to distinguish indolent from aggressive tumours is a high priority. Stroma plays an important role during prostate ca...
Oncogenic mutations in histologically normal endometrium: the new normal? [0.03%]
组织学正常的子宫内膜中的致癌突变：新的“正常”吗？
Vivian Lac,Tayyebeh M Nazeran,Basile Tessier-Cloutier et al.
Vivian Lac et al.
The advent of next generation sequencing has vastly improved the resolution of mutation detection, thereby both increasing the resolution of the analysis of cancer tissues and shining light on the existence of somatic driver mutations in no...
Anthony W-H Chan,Zhe Zhang,Charing C-N Chong et al.
Anthony W-H Chan et al.
Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a distinct variant of HCC that is characterized by dense tumor-infiltrating lymphocytes (TILs). Patients with LEL-HCC also show better clinical outcomes compared to conventional H...
Comparative Study
The Journal of pathology. 2019 Oct;249(2):166-172. DOI:10.1002/path.5313 2019
Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking [0.03%]
Rab25丢失通过整合素转运失调促进皮肤鳞状细胞癌的发展
Haengdueng Jeong,Kyung-Min Lim,Kwang H Kim et al.
Haengdueng Jeong et al.
Rab25 can function as both a tumor suppressor and a tumor promoter across different tissues. This study sought to clarify the role of Rab25 as a tumor suppressor in skin squamous cell carcinoma (SCC). Rab25 loss was closely associated with ...
Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice [0.03%]
人工智能在数字病理学中的应用：临床实践常规使用路线图
Richard Colling,Helen Pitman,Karin Oien et al.
Richard Colling et al.
The use of artificial intelligence will transform clinical practice over the next decade and the early impact of this will likely be the integration of image analysis and machine learning into routine histopathology. In the UK and around th...
Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway [0.03%]
FBXO7缺失通过RPL23-MDM2-TP53通路引起类似帕金森病的多巴胺神经元变性
Simon Rw Stott,Suzanne J Randle,Sara Al Rawi et al.
Simon Rw Stott et al.
The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with both sporadic Parkinson's dise...
Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis [0.03%]
线粒体功能紊乱和Harakiri在肌炎发病机制中的作用
Jessica F Boehler,Adam Horn,James S Novak et al.
Jessica F Boehler et al.
The etiology of myositis is unknown. Although attempts to identify viruses in myositis skeletal muscle have failed, several studies have identified the presence of a viral signature in myositis patients. Here we postulate that in individual...