Mice with a conditional deletion of Talpid3 (KIAA0586) - a model for Joubert syndrome [0.03%]
Talpid3(KIAA0586)条件性缺陷小鼠——JBTS模型小鼠
Andrew L Bashford,Vasanta Subramanian
Andrew L Bashford
Joubert syndrome (JS) is a ciliopathy associated with mutations in numerous genes encoding cilia components. TALPID3 encoded by KIAA0856 in man (2700049A03Rik in mouse) is a centrosomal protein essential for the assembly of primary cilia. M...
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme [0.03%]
条件性敲除尿生殖窦间充质中Gata2基因导致小鼠尿道平滑肌分化延迟和肾积水形成
Anna-Carina Weiss,Tobias Bohnenpoll,Jennifer Kurz et al.
Anna-Carina Weiss et al.
The establishment of the peristaltic machinery of the ureter is precisely controlled to cope with the onset of urine production in the fetal kidney. Retinoic acid (RA) has been identified as a signal that maintains the mesenchymal progenito...
Mineralocorticoid receptor negatively regulates angiogenesis through repression of STAT3 activity in endothelial cells [0.03%]
矿皮质激素受体通过抑制内皮细胞中信号转导及转录激活因子3活性负向调控血管生成
Xiao-Jun Zheng,Yuan Liu,Wu-Chang Zhang et al.
Xiao-Jun Zheng et al.
The mineralocorticoid receptor (MR) plays important roles in cardiovascular pathogenesis. The function of MR in angiogenesis is still controversial. This study aimed to explore the role of endothelial MR in angiogenesis and to delineate the...
Mis-splicing in breast cancer: identification of pathogenic BRCA2 variants by systematic minigene assays [0.03%]
乳腺癌中的错拼接：通过系统性微型基因测定鉴定致病BRCA2变异体
Eugenia Fraile-Bethencourt,Alberto Valenzuela-Palomo,Beatriz Díez-Gómez et al.
Eugenia Fraile-Bethencourt et al.
Splicing disruption is a common mechanism of gene inactivation associated with germline variants of susceptibility genes. To study the role of BRCA2 mis-splicing in hereditary breast/ovarian cancer (HBOC), we performed a comprehensive analy...
Malcolm R Alison,Wey-Ran Lin
Malcolm R Alison
Extensive bile ductular reactions (DRs) accompany many cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis (PSC) as well as parenchymal liver cell diseases such as alcoholic liver disease, non-a...
Increased expression of neurotensin in high grade serous ovarian carcinoma with evidence of serous tubal intraepithelial carcinoma [0.03%]
高级别浆液性卵巢癌中神经紧张素的表达增强，并有证据表明存在浆液性输卵管上皮内癌
Eric J Norris,Qing Zhang,Wendell D Jones et al.
Eric J Norris et al.
High grade serous ovarian carcinoma (HGSC) without identifiable serous tubal intraepithelial carcinoma (STIC) within the fallopian tube (FT) occurs in approximately 50% of patients. The objective of this study was to use a multisite tumor s...
Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice [0.03%]
反义吗啉寡核苷酸介导的跳跃型外显子剪接在小鼠中诱发抗营养素的细胞和体液免疫反应
Maria C Vila,James S Novak,Margaret Benny Klimek et al.
Maria C Vila et al.
Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne muscular dystrophy (DMD). The potential for newly synthesized dystrophin to trigger an immune response in DMD patient...
IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer [0.03%]
白细胞介素8和趋化因子CXCR1的表达与透明细胞肾癌干细胞样属性有关
Claudia Corrò,Marc E Healy,Stefanie Engler et al.
Claudia Corrò et al.
Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of cancer stem cells (CSCs) that might contribute to tumor heterogeneity, metastasis and therapeutic resistance. Nevertheless, their relevance f...
TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target [0.03%]
TET1重新编程卵巢癌表观基因组并揭示酪蛋白激酶2α作为治疗靶点
Lin-Yu Chen,Rui-Lan Huang,Michael Wy Chan et al.
Lin-Yu Chen et al.
Ten-eleven translocation methylcytosine dioxygenase-1, TET1, takes part in active DNA demethylation. However, our understanding of DNA demethylation in cancer biology and its clinical significance remain limited. This study showed that TET1...
Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma [0.03%]
不典型导管增生是乳腺癌的一种多潜能前体细胞病變
Tanjina Kader,Prue Hill,Magnus Zethoven et al.
Tanjina Kader et al.
The current model for breast cancer progression proposes independent 'low grade (LG)-like' and 'high grade (HG)-like' pathways but lacks a known precursor to HG cancer. We applied low-coverage whole-genome sequencing to atypical ductal hype...