Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles [0.03%]
乳腺癌中Tspan8的表达及其对E-钙粘蛋白/ catenin信号传导和转移以及循环细胞外囊泡增多的影响
Maren Voglstaetter,Andreas R Thomsen,Jerome Nouvel et al.
Maren Voglstaetter et al.
Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in t...
PGC-1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI [0.03%]
缺Pgc-1α导致自发性肾炎及增加肾毒性的急性肾损伤的严重程度
Miguel Fontecha-Barriuso,Diego Martín-Sánchez,Julio M Martinez-Moreno et al.
Miguel Fontecha-Barriuso et al.
PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α, PPARGC1A) regulates the expression of genes involved in energy homeostasis and mitochondrial biogenesis. Here we identify inactivation of the transcriptional regulat...
MAPK pathway activity plays a key role in PD-L1 expression of lung adenocarcinoma cells [0.03%]
MAPK信号通路活性在肺腺癌细胞PD-L1表达中起关键作用
Thijs S Stutvoet,Arjan Kol,Elisabeth Ge de Vries et al.
Thijs S Stutvoet et al.
Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have improved the survival of patients with non-small cell lung cancer (NSCLC). Still, many patients do not respond to these...
Tània Cemeli,Marta Guasch-Vallés,Mireia Nàger et al.
Tània Cemeli et al.
Glioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The cyclin D1 (Ccnd1)/Cdk4-retinoblastoma 1 (RB1) axis is frequently altered in GBM, leading to overproliferation by RB1 dele...
Prosaposin is a biomarker of mesenchymal glioblastoma and regulates mesenchymal transition through the TGF-β1/Smad signaling pathway [0.03%]
Prosaposin是一个间充质胶质母细胞瘤的生物标志物并通过TGF-β1/Smad信号通路调控间充质转化
Yang Jiang,Jinpeng Zhou,Dianqi Hou et al.
Yang Jiang et al.
Mesenchymal glioblastoma (GBM) is the most aggressive subtype of GBM. Our previous study found that neurotrophic factor prosaposin (PSAP) is highly expressed and secreted in glioma and can promote the growth of glioma. The role of PSAP in m...
CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice [0.03%]
CBP/p300对抗EGFR-Ras-Erk信号传导并抑制Ras-Erk信号传导增强引起的小鼠肿瘤发生
Taeko Ichise,Nobuaki Yoshida,Hirotake Ichise
Taeko Ichise
CREB-binding protein (CBP) and p300 have oncogenic properties; both co-operate with pro-oncogenic transcription factors downstream of Ras-Erk signalling to support cell proliferation. By contrast, missense, truncating and in-frame mutations...
YWHAZ amplification/overexpression defines aggressive bladder cancer and contributes to chemo-/radio-resistance by suppressing caspase-mediated apoptosis [0.03%]
YWHAZ扩增/过表达定义了侵袭性膀胱癌并通过抑制半胱天冬酶介导的细胞凋亡来促进化疗和放疗抗性
Chia-Cheng Yu,Chien-Feng Li,I-Hsuan Chen et al.
Chia-Cheng Yu et al.
The objective of this study was to characterize the oncogenic actions of a recently identified cancer-associated gene YWHAZ (also named as 14-3-3 ζ/δ) in urothelial carcinomas of the urinary bladder (UCUB). A genome-wide study revealed YW...
Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells [0.03%]
骨髓源性巨噬细胞通过激活肝星状细胞促进肝脂肪变性炎症纤维化
Juqiang Han,Xiang Zhang,Jennie K-C Lau et al.
Juqiang Han et al.
The role of macrophages in fibrosing steatohepatitis is largely unclear. We characterized the origin and molecular mechanisms of macrophages and its targeted therapy of fibrosing steatohepatitis. Fibrosing steatohepatitis was established in...
Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer [0.03%]
炎症依赖的c-Myc过度表达增强CRL4DCAF4E3连接酶活性并促进ST7在结肠炎相关癌症中的泛素化
Hong Liu,Wenzhu Lu,Hongbo He et al.
Hong Liu et al.
Inflammation is well known as an important driver of the initiation of colitis-associated cancer (CAC). Some cytokines, such as IL-6 and TNF-α can activate expression of the oncogene c-Myc (MYC) and regulate its downstream effects. Cullin-...