A new mouse model for the neurodevelopmental ciliopathy Joubert syndrome [0.03%]
一种新的用于神经发育纤毛病Joubert综合征的小鼠模型
Ruxandra Bachmann-Gagescu
Ruxandra Bachmann-Gagescu
Recent recognition of the key role of primary cilia in orchestrating human development and of the dire consequences of their dysfunction on human health has placed this small organelle in the spotlight. While the causal link between mutatio...
Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts [0.03%]
FGF/FGFR信号传导通路抑制对肺腺癌及其癌症相关成纤维细胞的影响研究
Ahmed E Hegab,Mari Ozaki,Naofumi Kameyama et al.
Ahmed E Hegab et al.
Cancer-associated fibroblasts (CAFs) are known to promote tumourigenesis through various mechanisms. Fibroblast growth factor (FGF)/FGF receptor (FGFR)-dependent lung cancers have been described. We have developed a mouse model of lung aden...
'Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction' [0.03%]
"单侧输尿管梗阻后B淋巴细胞肾内募集通过促进单核细胞动员和浸润加重 tubulointerstitial纤维化"
Published Erratum
The Journal of pathology. 2019 Jun;248(2):253. DOI:10.1002/path.5272 2019
Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors [0.03%]
WWOX基因胚系突变及异常转录在多原发肿瘤综合征中的作用
Ao Xu,Wei Wang,Jinfu Nie et al.
Ao Xu et al.
Multiple primary tumors are defined by the presence of two or more independent primary tumors in the same or different organs of an individual patient. However, the underlying genetic cause for the development of multiple primary tumors is ...
Case Reports
The Journal of pathology. 2019 Sep;249(1):19-25. DOI:10.1002/path.5288 2019
Xiao Zhang,Satoshi Yamashita,Kentaro Hara et al.
Xiao Zhang et al.
Mutations in the Matrin 3 (MATR3) gene have been identified as a cause of amyotrophic lateral sclerosis (ALS) or vocal cord and pharyngeal weakness with distal myopathy (VCPDM). This study investigated the mechanism by which mutant MATR3 ca...
c-Met-dependent phosphorylation of RhoA plays a key role in gastric cancer tumorigenesis [0.03%]
c-Met依赖的RhoA磷酸化在胃癌发生中起关键作用
Jianjun Liu,Shun Li,Shangxiang Chen et al.
Jianjun Liu et al.
RhoA has been identified as having a gain-of-function mutation in approximately 20% of diffuse gastric cancer patients. However, the carcinogenic role of RhoA mutations in gastric cancer (GC) is unclear. In the present study, we report that...
Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury [0.03%]
四关节敲除延迟ADPKD模型肾损伤的肾衰竭发生
Chiara Formica,Hester Happé,Kimberley Am Veraar et al.
Chiara Formica et al.
Autosomal Dominant Polycystic Kidney Disease is characterised by the development of fluid-filled cysts in the kidneys which lead to end-stage renal disease (ESRD). In the majority of cases, the disease is caused by a mutation in the Pkd1 ge...
Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis [0.03%]
5-羟色胺合成保护小鼠结肠隐窝免受DNA损伤和大肠肿瘤发生的作用
Juliana Y Sakita,Michael Bader,Emerson S Santos et al.
Juliana Y Sakita et al.
Serotonin (5-HT) signaling pathways are thought to be involved in colorectal tumorigenesis (CRT), but the role of 5-HT synthesis in the early steps of this process is presently unknown. In this study, we used carcinogen treatment in the try...
NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas [0.03%]
NR4A3融合蛋白触发轴突导向转换，以区分EWSR1和TAF15易位的 Extraskeletal肌样软骨肉瘤
Monica Brenca,Silvia Stacchiotti,Kelly Fassetta et al.
Monica Brenca et al.
Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma histotype with uncertain differentiation. EMC is hallmarked by the rearrangement of the NR4A3 gene, which in most cases fuses with EWSR1 or TAF15. TAF15-translocated EMC seem to fe...
Multicenter Study
The Journal of pathology. 2019 Sep;249(1):90-101. DOI:10.1002/path.5284 2019
Intraductal carcinoma of the prostate in the absence of high-grade invasive carcinoma represents a molecularly distinct type of in situ carcinoma enriched with oncogenic driver mutations [0.03%]
无高分级浸润性癌的前列腺导管内癌是一种富含致癌驱动基因突变的原位癌类型
Francesca Khani,Sara E Wobker,Jessica L Hicks et al.
Francesca Khani et al.
Intraductal carcinoma of the prostate (IDC-P) most often appears associated with high-grade invasive prostate carcinoma (PCa), where it is believed to represent retrograde spread. However, IDC-P rarely occurs as an isolated finding at radic...