Oncogenic mutations in histologically normal endometrium: the new normal? [0.03%]
组织学正常的子宫内膜中的致癌突变：新的“正常”吗？
Vivian Lac,Tayyebeh M Nazeran,Basile Tessier-Cloutier et al.
Vivian Lac et al.
The advent of next generation sequencing has vastly improved the resolution of mutation detection, thereby both increasing the resolution of the analysis of cancer tissues and shining light on the existence of somatic driver mutations in no...
Anthony W-H Chan,Zhe Zhang,Charing C-N Chong et al.
Anthony W-H Chan et al.
Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a distinct variant of HCC that is characterized by dense tumor-infiltrating lymphocytes (TILs). Patients with LEL-HCC also show better clinical outcomes compared to conventional H...
Comparative Study
The Journal of pathology. 2019 Oct;249(2):166-172. DOI:10.1002/path.5313 2019
Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking [0.03%]
Rab25丢失通过整合素转运失调促进皮肤鳞状细胞癌的发展
Haengdueng Jeong,Kyung-Min Lim,Kwang H Kim et al.
Haengdueng Jeong et al.
Rab25 can function as both a tumor suppressor and a tumor promoter across different tissues. This study sought to clarify the role of Rab25 as a tumor suppressor in skin squamous cell carcinoma (SCC). Rab25 loss was closely associated with ...
Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice [0.03%]
人工智能在数字病理学中的应用：临床实践常规使用路线图
Richard Colling,Helen Pitman,Karin Oien et al.
Richard Colling et al.
The use of artificial intelligence will transform clinical practice over the next decade and the early impact of this will likely be the integration of image analysis and machine learning into routine histopathology. In the UK and around th...
Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway [0.03%]
FBXO7缺失通过RPL23-MDM2-TP53通路引起类似帕金森病的多巴胺神经元变性
Simon Rw Stott,Suzanne J Randle,Sara Al Rawi et al.
Simon Rw Stott et al.
The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with both sporadic Parkinson's dise...
Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis [0.03%]
线粒体功能紊乱和Harakiri在肌炎发病机制中的作用
Jessica F Boehler,Adam Horn,James S Novak et al.
Jessica F Boehler et al.
The etiology of myositis is unknown. Although attempts to identify viruses in myositis skeletal muscle have failed, several studies have identified the presence of a viral signature in myositis patients. Here we postulate that in individual...
Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium [0.03%]
谱系追踪表明卵巢内输卵管病不是由输卵管上皮逃逸所致
Yisheng Wang,Michael S Sessine,Yali Zhai et al.
Yisheng Wang et al.
Most high-grade serous carcinomas are thought to arise from Fallopian tube epithelium (FTE), but some likely arise outside of the tube, perhaps from ectopic tubal-type epithelium known as endosalpingiosis. Importantly, the origin of endosal...
Mahmut Akgul,Gregory T MacLennan,Liang Cheng
Mahmut Akgul
A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3, and TP53/RB1genes. Neither r...
Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches [0.03%]
一项独特的研究膀胱癌的课题：了解癌症免疫并开发免疫治疗途径
Dongkui Song,Thomas Powles,Lei Shi et al.
Dongkui Song et al.
With the mechanistic understanding of immune checkpoints and success in checkpoint blockade using antibodies for the treatment of certain cancers, immunotherapy has become one of the hottest areas in cancer research, with promise of long-la...
From latency to overt bone metastasis in breast cancer: potential for treatment and prevention [0.03%]
从乳腺癌的隐匿骨转移至明显骨转移：治疗与预防的潜能
Fernando Salvador,Alicia Llorente,Roger R Gomis
Fernando Salvador
Bone metastasis is present in a high percentage of breast cancer (BCa) patients with distant disease, especially in those with the estrogen receptor-positive (ER+ ) subtype. Most cells that escape primary tumors are unable to establish meta...