Super resolution of pathology images with hierarchical feature integration and local image patterns [0.03%]
基于层次特征整合和局部图像模式的病理图像超分辨率重建方法
Feng Xu,Lei Li,Shuyang Wang et al.
Feng Xu et al.
Recent advancements in pathological imaging have facilitated single-cell and subcellular-level analysis based on high-resolution images for tumor subtyping, cytomorphological assessment, and infection detection. As high-resolution imaging i...
DNA-hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53 mutation [0.03%]
无TP53基因突变的胃癌细胞通过过度甲基化DNA来抑制细胞凋亡
Yasunobu Mano,Keisuke Matsusaka,Motoaki Seki et al.
Yasunobu Mano et al.
p53 is one of the most important tumour suppressors exerting antitumour effects primarily via apoptosis. TP53 mutations are common in gastric tumorigenesis; however, nearly half of the gastric cancers (GCs) remain wildtype TP53 (TP53_WT). W...
Expression of SARS-CoV-2 entry-associated proteins in COPD airways: an immunohistochemical study [0.03%]
慢性阻塞性肺疾病气道中SARS-CoV-2入侵相关蛋白的表达：免疫组化研究
Larissa E Vlaming-van Eijk,Zarlasht Sarsam,Janna Bakker et al.
Larissa E Vlaming-van Eijk et al.
Coronavirus disease 2019 (COVID-19) is of special concern to patients with chronic obstructive pulmonary disease (COPD), given their susceptibility to exacerbations caused by respiratory tract infections. As the susceptibility of acquiring ...
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers [0.03%]
KMT2D缺陷增强泌尿系统肿瘤的抗肿瘤免疫并使其对免疫检查点阻断更敏感
Yuedian Ye,Yuanpeng Liao,Yifan Zhang et al.
Yuedian Ye et al.
Immune checkpoint blockade (ICB) therapy has made remarkable advances in cancer treatment. However, the overall response rate remains limited. Here, we aim to explore the role of histone 3 lysine 4 mono-methyltransferase KMT2D in tumor immu...
Androgen receptor-mediated regulation of BRCA1 modulates the antioxidant defense in prostate cancer [0.03%]
雄激素受体介导的BRCA1调节调控前列腺癌中的抗氧化防御功能
Saiganesh Sriraman,Verneri Virtanen,Antti Kukkula et al.
Saiganesh Sriraman et al.
Lethal prostate cancer (PCa) is a genetically heterogeneous disease characterized by evolving androgen receptor (AR) signaling, eventually culminating in castration resistance. The tumor suppressor gene BRCA1 has multiple functions that inc...
Mutation profiling in differential diagnosis between TdT-positive high-grade/large B-cell lymphoma and B-lymphoblastic leukaemia/lymphoma [0.03%]
TdT阳性高级别/大B细胞淋巴瘤与B淋巴母细胞白血病/淋巴瘤的鉴别诊断中的突变谱分析
Maria-Myrsini Tzioni,Francesco Cucco,Lívia Rásó-Barnett et al.
Maria-Myrsini Tzioni et al.
Terminal deoxynucleotidyl transferase (TdT) is occasionally expressed in large B-cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B-lymphoblastic leukaemia/lymphoma (B-ALL/LBL). We reviewed 31 cases of TdT-pos...
Advancing homebrew AI in diagnostic practice: opportunities and barriers† [0.03%]
推进诊断实践中的民间人工智能：机遇与障碍
Zaid H Khoury,Ahmed S Sultan
Zaid H Khoury
In a recent issue of The Journal of Pathology, Calderaro et al present a timely and persuasive argument advocating for the integration of homebrew artificial intelligence (AI) models in diagnostic pathology. Their article is a robust defens...
Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer [0.03%]
肠上皮内瘤变向结直肠癌进展的时空调控机制及早诊标志物研究
Sangkyou Lee,Sung Yun Jung,Pawel Kuś et al.
Sangkyou Lee et al.
Multiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole-organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis...
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing [0.03%]
利用拷贝数和靶向深度测序追溯儿童实体瘤的转移路径
Natalie Andersson,Michele Ferro,Caroline Jansson et al.
Natalie Andersson et al.
The most common cause of death in pediatric cancer patients is a treatment-resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanis...