High-fat diets influence breast cancer progression by modulating CAF-immune cell interactions through PLAT signaling [0.03%]
高脂饮食通过PLAT信号调节癌相关成纤维细胞-免疫细胞相互作用影响乳腺癌进展
Weihan Li,Jiangshan He,Jingjing Li et al.
Weihan Li et al.
Breast cancer progression is profoundly influenced by interactions within the tumor microenvironment, particularly between cancer-associated fibroblasts and immune cells. This study investigated how cancer-associated fibroblasts impact immu...
APC-related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation [0.03%]
与APC相关的多个唾液腺病变：空间转录组分析揭示了WNT激活的渐进式变化
Fiona Chan-Pak-Choon,Catherine Beaumont,José Camacho Valenzuela et al.
Fiona Chan-Pak-Choon et al.
Attenuated familial adenomatous polyposis (AFAP) is a disorder caused by germline pathogenic variants in APC and is characterized by the presence of
Overexpression of m7G writers METTL1 and BUD23 confers oncogenicity in kidney renal clear cell carcinoma [0.03%]
METTL1和BUD23的过度表达通过m7G修饰促肾细胞癌发生发展
Anni Su,Jessica Tieng,Xueying S Xu et al.
Anni Su et al.
Emerging evidence shows that N7-methylguanosine (m7G) modification and its writers contribute to the development of diverse cancers. However, the role of m7G writers in kidney renal clear cell carcinoma (KIRC) remains unclear. In this study...
Characteristic miRNA profiles represent clinicopathological diversity of small cell lung cancer [0.03%]
特征性微小核糖核酸谱系代表小细胞肺癌的临床病理差异性
Masafumi Horie,Hiroshi Takumida,Hayato Koba et al.
Masafumi Horie et al.
Small cell lung cancer (SCLC) is classified into distinct molecular subtypes based on the expression patterns of four transcription regulators: achaete-scute homolog 1 (ASCL1), neuronal differentiation 1 (NEUROD1), POU class 2 homeobox 3 (P...
STING inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis [0.03%]
STING抑制可减轻实验性腹膜损害：可能对腹膜透析具有治疗意义
Vanessa Marchant,Jorge García-Jiménez,Guadalupe T González-Mateo et al.
Vanessa Marchant et al.
Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end-stage kidney disease. Nevertheless, long-term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultima...
Activation of PI3K and deletion of p53 in keratin 15-expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer [0.03%]
小鼠乳癌细胞中活化PI3K和删除p53以及表达角蛋白15诱导肿瘤异质性和可塑性以类比遗传性乳腺癌
Khoa A Nguyen,Lauren E McLemore,Yao Ke et al.
Khoa A Nguyen et al.
Although relatively rare, metaplastic breast cancer responds poorly to traditional therapies compared to other subtypes. Accordingly, there is a need for novel animal models to understand its pathogenesis and plasticity. Since alterations i...
MS4A4A-positive tumor-associated macrophages associate with poor prognosis and T-cell exhaustion in patients with urothelial carcinoma of the bladder [0.03%]
MS4A4A阳性肿瘤相关巨噬细胞与膀胱尿路上皮癌患者预后不良和T细胞衰竭相关
Tenghao Yang,Xi Sun,Jiaming Chen et al.
Tenghao Yang et al.
Tumor-associated macrophages (TAMs) have multiple potent functions in cancer representing important therapeutic targets. MS4A4A is a functional TAM marker with controversial implications for prognosis. This study aimed to evaluate the assoc...
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions [0.03%]
基于归档的FFPE样本对原发性神经母细胞瘤微环境进行空间转录组学探索，揭示了新的旁分泌相互作用
Joachim T Siaw,Peter Merseburger,Marcus Borenäs et al.
Joachim T Siaw et al.
High-risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single-cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about loca...
Revisionist history uncovers a simplified molecular-based classification of differentiated thyroid cancer [0.03%]
修正历史发现基于分子的分化型甲状腺癌分类被简化
Sylvia L Asa,Zubair Baloch,Chan Kwon Jung et al.
Sylvia L Asa et al.
The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and su...
Increased expression of the PIEZO2 mechanoreceptor in fibroblasts and endothelial cells within the lymphatic and vascular vessels of keloids [0.03%]
成纤维细胞和内皮细胞中的PIEZO2机械受体在瘢痕组织中表达量增加
Shinsuke Akita,Sanae Ikehara,Masahiro Kiuchi et al.
Shinsuke Akita et al.
Keloids are scars that grow abnormally due to excessive extracellular matrix production by fibroblasts and increased angiogenesis. Chronic tension is implicated in their growth, but the exact pathology remains unclear. This study investigat...