Novel growth pattern-specific digital marker of TILs improves stratification of lung adenocarcinoma patients [0.03%]
新颖的肿瘤浸润淋巴细胞生长模式特异性数字标记物可改善肺腺癌患者的分层治疗效果
Arwa AlRubaian,Ayesha Azam,Nasir M Rajpoot et al.
Arwa AlRubaian et al.
Lung adenocarcinoma (LUAD) is one of the most prevalent forms of cancer and continues to be associated with high mortality rates, despite recent advances in cancer therapy. Effective risk stratification is critical for guiding treatment dec...
Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation [0.03%]
乳腺癌易感基因+2T变异体非典要捐赠剪接位点的生成及其对临床解释的影响
Inés Llinares-Burguet,Lara Sanoguera-Miralles,Elena Bueno-Martínez et al.
Inés Llinares-Burguet et al.
Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5' splice sites (5'ss) are generally strong indicators of...
Clinical outcomes and immune contexture in SMARCA4-deficient gastric cancer patients [0.03%]
SMARCA4缺陷型胃癌患者的临床转归及其免疫微环境研究
Mengyao Sun,Yun Gu,Jieti Wang et al.
Mengyao Sun et al.
Exploiting vulnerabilities in switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes for cancer therapy is a promising therapeutic strategy. The SWI/SNF chromatin remodeling complex acts as a regulatory component of transcri...
Hypoxia-induced regional heterogeneity in proliferative vitreoretinopathy: implications for targeted therapies [0.03%]
缺氧诱导的增生性玻璃体视网膜病变区域性异质性的研究及其对靶向治疗的意义
Wenjie Yin,Miao Xu,Yan Gao et al.
Wenjie Yin et al.
Proliferative vitreoretinopathy (PVR) represents a common and challenging complication leading to blindness following ocular injury. The prevailing view, which guides current drug development efforts, posits that the mesenchymal transition ...
Molecular evidence of a clonal relationship of synchronous/multifocal gastric-type lesions of the female genital tract [0.03%]
女性生殖道同步/多发胃型病变克隆关系的分子证据
Min Shi,Hong Yang,Fang Zhang et al.
Min Shi et al.
Synchronous/multifocal gastric-type lesions (SMGLs) of the female genital tract are heterogeneous diseases that are rare and challenging to diagnose. The core issue is distinguishing between multiple primaries and multifocal metastases from...
Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease [0.03%]
转录组谱分析揭示Hedgehog信号传导作为Menetrier病生物标志物及在疾病发生发展中的作用
Miyoung Shin,Tryston T Gabriel,Fred Kwame Ofosu et al.
Miyoung Shin et al.
Both Ménétrier's disease (MD) and juvenile polyposis syndrome (JPS) are rare premalignant conditions that can lead to gastric cancer. MD is an acquired disease without known causative mutations that is characterized by increased expressio...
Contrastive virtual staining enhances deep learning-based PDAC subtyping from H&E-stained tissue cores [0.03%]
对比虚拟染色增强基于H&E染色组织核心的胰腺导管腺癌亚型的深度学习方法
Maximilian Fischer,Alexander Muckenhuber,Robin Peretzke et al.
Maximilian Fischer et al.
Pancreatic ductal adenocarcinoma (PDAC) subtyping typically relies on immunohistochemistry (IHC) staining for critical markers like HNF1A and KRT81, a labor-intensive manual staining process that introduces variability. Virtual staining met...
mTOR-mediated upregulation of B7-H3 in MiT/TFE translocation renal cell carcinoma [0.03%]
MiT/TFE易位肾细胞癌中mTOR介导的B7-H3上调
Huili Li,Adrianna Amaral,Thiago Vidotto et al.
Huili Li et al.
Clinical trials targeting B7-H3 (CD276), a membranous immunomodulatory molecule in the B7 superfamily, have shown promise in prostate cancer and may be expanded to additional tumor types with high expression, such as those with mTOR signali...
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression [0.03%]
系谱分析配对乳腺癌鉴定与克隆复发和侵袭性进展相关的遗传事件
Tanjina Kader,Maia Zethoven,Sakshi Mahale et al.
Tanjina Kader et al.
Development of ipsilateral breast carcinoma following a diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not always be the case, and it is important to det...
MicroRNA profiling of testicular Leydig cell tumors identifies a microRNA signature associated with malignancy and miR-196b-5p as a potentially useful biomarker [0.03%]
微RNA谱分析发现曲细精管间质细胞肿瘤恶性转化相关微RNA标记及miR-196b-5p作为潜在生物标志物
João Lobo,Nuno Tiago Tavares,Fernanda Fernandes-Pontes et al.
João Lobo et al.
Approximately 10% of testicular Leydig cell tumors (LCTs) are clinically malignant and unresponsive to systemic treatment. Predicting their clinical behavior can be problematic because there are no biomarkers that can consistently discrimin...