Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity [0.03%]
胶质瘤细胞的间充质转化和治疗抵抗性增强与星形胶质细胞活化有关
Mia Niklasson,Tobias Bergström,Malin Jarvius et al.
Mia Niklasson et al.
Grade IV astrocytoma/glioblastoma multiforme (GBM) is essentially incurable, partly due to its heterogenous nature, demonstrated even within the glioma-initiating cell (GIC) population. Increased therapy resistance of GICs is coupled to tra...
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages [0.03%]
POU1F1转录因子通过募集和极化巨噬细胞促进乳腺癌转移
Samuel Seoane,Anxo Martinez-Ordoñez,Noemi Eiro et al.
Samuel Seoane et al.
Cancer progression requires cells surrounding tumors be reeducated and activated to support tumor growth. Oncogenic signals from malignant cells directly influence stromal composition and activation, but the factors mediating this communica...
Cold atmospheric plasma modulates endothelial nitric oxide synthase signalling and enhances burn wound neovascularisation [0.03%]
冷等离子体调节内皮型一氧化氮合酶信号并增强烧伤伤口新生血管生成
Constance Duchesne,Sébastien Banzet,Jean-Jacques Lataillade et al.
Constance Duchesne et al.
Treatment with cold atmospheric plasma (CAP) has been reported to promote wound healing in animals. However, how this process is mediated remains unclear. In this study we examined the mechanisms which underlie the improved wound healing ef...
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy [0.03%]
整合素αvβ6通过多种机制驱动胰腺癌，是治疗的有效靶标
Claire S Reader,Sabari Vallath,Colin W Steele et al.
Claire S Reader et al.
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 4% and desperately needs novel effective therapeutics. Integrin αvβ6 has been linked with poor prognosis in cancer but its potential as a target in PDAC remai...
Multicenter Study
The Journal of pathology. 2019 Nov;249(3):332-342. DOI:10.1002/path.5320 2019
Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension [0.03%]
自噬通过促进骨形态发生蛋白受体Ⅱ型的降解参与肺动脉高压的发展
Maria Catalina Gomez-Puerto,Iris van Zuijen,Christopher Jz Huang et al.
Maria Catalina Gomez-Puerto et al.
Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure which almost invariably leads to right heart failure and premature death. More than 70% of familial PAH and 20% of idiopathic PAH pati...
Neuropilin-2 contributes to tumor progression in preclinical models of small intestinal neuroendocrine tumors [0.03%]
神经退行性肿瘤贡献了小肠神经内分泌肿瘤的前临床模型中的肿瘤进展神经系统素-2
Julien Bollard,Céline Patte,Kristina Radkova et al.
Julien Bollard et al.
The identification of novel regulators of tumor progression is a key challenge to gain knowledge on the biology of small intestinal neuroendocrine tumors (SI-NETs). We recently identified the loss of the axon guidance protein semaphorin 3F ...
Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma [0.03%]
儿童原发性和转移性骨肉瘤的集成基因组分析
Gian Luca Negri,Bruno M Grande,Alberto Delaidelli et al.
Gian Luca Negri et al.
Despite being the most common childhood bone tumor, the genomic characterization of osteosarcoma remains incomplete. In particular, very few osteosarcoma metastases have been sequenced to date, critical to better understand mechanisms of pr...
Multicenter Study
The Journal of pathology. 2019 Nov;249(3):319-331. DOI:10.1002/path.5319 2019
Carina Bernardo,Pontus Eriksson,Nour-Al-Dain Marzouka et al.
Carina Bernardo et al.
Molecular subtypes of urothelial carcinoma may be divided into luminal and nonluminal tumors. Nonluminal tumors are composed of cases with basal/squamous-like or small cell/neuroendocrine features, with a consensus on the molecular characte...
Gamma-secretase complex-dependent intramembrane proteolysis of CD147 regulates the Notch1 signaling pathway in hepatocellular carcinoma [0.03%]
泛分泌酶复合物介导的CD147内膜蛋白水解调控肝癌中Notch1信号通路
Yu-Le Yong,Ren-Yu Zhang,Ze-Kun Liu et al.
Yu-Le Yong et al.
The γ-secretase complex is a presenilin-dependent aspartyl protease involved in the intramembranous cleavage of various type I transmembrane proteins. As a type I transmembrane protein, CD147 is highly expressed in hepatoma cells and promo...
Development of a predictive model for stromal content in prostate cancer samples to improve signature performance [0.03%]
开发预测前列腺癌样本间质含量的模型以提高标志物性能
Nadia Boufaied,Mandeep Takhar,Claire Nash et al.
Nadia Boufaied et al.
Prostate cancer is heterogeneous in both cellular composition and patient outcome, and development of biomarker signatures to distinguish indolent from aggressive tumours is a high priority. Stroma plays an important role during prostate ca...