Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis [0.03%]
CBP/p300失活突变在皮肤肿瘤发生中的作用机制探究
Sergio Anastasi,Stefano Alemà,Oreste Segatto
Sergio Anastasi
CBP and p300 are highly homologous lysine acetyltransferases involved in cell cycle regulation, DNA synthesis and DNA repair. Loss of function mutations of CBP and p300 are found in about one-third of cutaneous squamous cell carcinoma (cSCC...
Zehua Li,Ji Wu,Xiuli Zhang et al.
Zehua Li et al.
Vascular calcification is prevalent in patients with chronic kidney disease (CKD) and a major risk factor of cardiovascular disease. Vascular calcification is now recognised as a biological process similar to bone formation involving osteog...
Zehua Li,Ji Wu,Xiuli Zhang et al.
Zehua Li et al.
Vascular calcification is prevalent in patients with chronic kidney disease (CKD) and a major risk factor of cardiovascular disease. Vascular calcification is now recognised as a biological process similar to bone formation involving osteog...
Lamin A/C deficiency in CD4+ T-cells enhances regulatory T-cells and prevents inflammatory bowel disease [0.03%]
Ⅳ型胶原酶佐剂结核菌素皮试在接触性过敏反应中的作用及其与Th1/Th2平衡的关系研究
Raquel Toribio-Fernández,Beatriz Herrero-Fernandez,Virginia Zorita et al.
Raquel Toribio-Fernández et al.
The mechanisms by which lamin A/C in CD4+ T-cells control intestinal homeostasis and can cause inflammatory bowel disease (IBD) are unknown. Here, we explore lamin A/C in a mouse model of IBD. Adoptive transfer to Rag1-/- mice of Lmna-/- CD...
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association [0.03%]
计算病理学定义、最佳实践及对监管指导的建议——数字病理学会白皮书
Esther Abels,Liron Pantanowitz,Famke Aeffner et al.
Esther Abels et al.
In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology, with a focus on its application to histology images analyzed together with their ass...
Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing [0.03%]
糖尿病通过使骨髓祖细胞偏向髓样从而增加伤口巨噬细胞浸润并导致愈合障碍
Pijus K Barman,Norifumi Urao,Timothy J Koh
Pijus K Barman
Diabetes induces dysregulation throughout the spectrum of myeloid lineage cells from progenitors to terminally differentiated cells. Another complication of diabetes is persistent inflammation, including prolonged accumulation of macrophage...
Yuezhen Xue,Boris San Luis,David P Lane
Yuezhen Xue
Genomic alterations in different types of cancer have been identified by comprehensive sequencing methodologies, revealing TP53 as the most frequently mutated gene across the majority of human cancer types. Cytotoxic treatments are still ma...
Autoimmune response and its long-term consequences after exon-skipping therapy in a Duchenne muscular dystrophy mouse model [0.03%]
杜氏肌营养不良小鼠模型中外显子跳读治疗后的自身免疫反应及其长期后果
Joel Z Nordin,Yoshitsugu Aoki
Joel Z Nordin
The progress of antisense-based therapies using first generation Morpholino oligonucleotides for Duchenne muscular dystrophy (DMD) is expected to partially restore dystrophin expression and may prolong the lifespan of DMD patients. In a rec...
Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile [0.03%]
携带PRDM10融合基因的多形性肉瘤具有独特的基因表达谱
Jakob Hofvander,Florian Puls,Nischalan Pillay et al.
Jakob Hofvander et al.
Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2-PRDM10 or a MED12-PRDM10 gene fusion. Preliminary data suggest that these so-called PRDM10-rearranged tumors (...
A miR-194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma [0.03%]
miR-194/PTBP1/CCND3信号轴调节人类肝癌细胞的肿瘤生长
Hoin Kang,Sungeun Heo,Jung Jae Shin et al.
Hoin Kang et al.
Polypyrimidine tract-binding protein 1 (PTBP1) is one of the most investigated multifunctional RNA-binding proteins (RBP), controlling almost all steps of mRNA metabolism and processing. It has been reported that PTBP1 is overexpressed in m...