The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis [0.03%]
ASPM各异构体的分布差异及其在Wnt信号传导、细胞周期进程和胰腺癌预后中的作用
Chung-Chi Hsu,Wen-Ying Liao,Tze-Sian Chan et al.
Chung-Chi Hsu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and treatment-resistant malignancy. The lack of pathway-informed biomarkers hampers the development of rational diagnostics or therapies. Recently, the protein abnormal spindle-...
The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma [0.03%]
转录因子FOXM1调控头颈鳞状细胞癌增殖和分化失常间的平衡
Vincent Roh,Agnès Hiou-Feige,Vinko Misetic et al.
Vincent Roh et al.
Sustained expression of FOXM1 is a hallmark of nearly all human cancers including squamous cell carcinomas of the head and neck (HNSCC). HNSCCs partially preserve the epithelial differentiation program, which recapitulates fetal and adult t...
Next generation pathology: artificial intelligence enhances histopathology practice [0.03%]
下一代病理学：人工智能增强组织病理学实践
Balazs Acs,Johan Hartman
Balazs Acs
Deep learning algorithms have shown benefits for pathology in the context of risk stratification of tumors. Although the results are promising, several steps have to be made to confirm clinical utility. In a recent issue of The Journal of P...
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease [0.03%]
一种抗癌药物治疗肥厚型心脏病的新用途
Matthew Dukinfield,Eleni Maniati,Louise E Reynolds et al.
Matthew Dukinfield et al.
Coronary microvascular dysfunction combined with maladaptive cardiomyocyte morphology and energetics is a major contributor to heart failure advancement. Thus, dually enhancing cardiac angiogenesis and targeting cardiomyocyte function to sl...
IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis [0.03%]
浆细胞样树突状细胞的白介素10促进子宫内膜异位症早期阶段的血管生成
Jau-Ling Suen,Yu Chang,Yu-Shiang Shiu et al.
Jau-Ling Suen et al.
An elevated level of IL-10 has been considered a critical factor for the development of endometriosis; however, its detailed mechanism and causal relationship remain unclear. This study explored the cellular source and angiogenic activity o...
Corrigendum [0.03%]
勘误表
Published Erratum
The Journal of pathology. 2019 Sep;249(1):137. DOI:10.1002/path.5329 2019
Genomic characterisation of breast fibroepithelial lesions in an international cohort [0.03%]
国际队列中乳腺纤维上皮性病变的基因组特征分析
Nur Diyana Md Nasir,Cedric Chuan Young Ng,Vikneswari Rajasegaran et al.
Nur Diyana Md Nasir et al.
Fibroepithelial lesions (FELs) are a heterogeneous group of tumours comprising fibroadenomas (FAs) and phyllodes tumours (PTs). Here we used a 16-gene panel that was previously discovered to be implicated in pathogenesis and progression, to...
Comparative Study
The Journal of pathology. 2019 Dec;249(4):447-460. DOI:10.1002/path.5333 2019
Overactivity or blockade of transforming growth factor-β each generate a specific ureter malformation [0.03%]
转化生长因子-β过度活化或被阻滞分别导致特定的输尿管畸形
Filipa M Lopes,Neil A Roberts,Leo Ah Zeef et al.
Filipa M Lopes et al.
Transforming growth factor-β (TGFβ) has been reported to be dysregulated in malformed ureters. There exists, however, little information on whether altered TGFβ levels actually perturb ureter development. We therefore hypothesised that T...
Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis [0.03%]
CBP/P300失活突变在皮肤肿瘤发生中的作用机制研究
Sergio Anastasi,Stefano Alemà,Oreste Segatto
Sergio Anastasi
CBP and p300 are highly homologous lysine acetyltransferases involved in cell cycle regulation, DNA synthesis and DNA repair. Loss of function mutations of CBP and p300 are found in about one-third of cutaneous squamous cell carcinoma (cSCC...