Mutation profiling in differential diagnosis between TdT-positive high-grade/large B-cell lymphoma and B-lymphoblastic leukaemia/lymphoma [0.03%]
TdT阳性高级别/大B细胞淋巴瘤与B淋巴母细胞白血病/淋巴瘤的鉴别诊断中的突变谱分析
Maria-Myrsini Tzioni,Francesco Cucco,Lívia Rásó-Barnett et al.
Maria-Myrsini Tzioni et al.
Terminal deoxynucleotidyl transferase (TdT) is occasionally expressed in large B-cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B-lymphoblastic leukaemia/lymphoma (B-ALL/LBL). We reviewed 31 cases of TdT-pos...
Advancing homebrew AI in diagnostic practice: opportunities and barriers† [0.03%]
推进诊断实践中的民间人工智能：机遇与障碍
Zaid H Khoury,Ahmed S Sultan
Zaid H Khoury
In a recent issue of The Journal of Pathology, Calderaro et al present a timely and persuasive argument advocating for the integration of homebrew artificial intelligence (AI) models in diagnostic pathology. Their article is a robust defens...
Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer [0.03%]
肠上皮内瘤变向结直肠癌进展的时空调控机制及早诊标志物研究
Sangkyou Lee,Sung Yun Jung,Pawel Kuś et al.
Sangkyou Lee et al.
Multiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole-organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis...
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing [0.03%]
利用拷贝数和靶向深度测序追溯儿童实体瘤的转移路径
Natalie Andersson,Michele Ferro,Caroline Jansson et al.
Natalie Andersson et al.
The most common cause of death in pediatric cancer patients is a treatment-resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanis...
Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand [0.03%]
泰国东北部肝内胆管癌的染色体不稳定性及基因组改变
Raksawan Deenonpoe,Molly A Guscott,Sasithorn Watcharadetwittaya et al.
Raksawan Deenonpoe et al.
Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverr...
Periostin-IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation [0.03%]
骨膜素-IHH正向环路通过增强肝纤维化和肿瘤细胞增殖促进肝癌发生发展
Bin Liu,Xuebin Li,Menghao Zhang et al.
Bin Liu et al.
The extracellular matrix protein periostin plays a critical role in the progression of hepatic fibrosis and hepatocellular carcinoma (HCC). However, little is known about how periostin regulates both hepatic fibrosis and tumor growth in the...
Investigating the mechanisms of indocyanine green tumour uptake in sarcoma cell lines and ex vivo human tissue [0.03%]
探究吲哚青绿在肉瘤细胞系和人体外组织中肿瘤摄取的机制
Corey David Chan,Marcus J Brookes,Toni A Pringle et al.
Corey David Chan et al.
Indocyanine green (ICG) is a well-established near-infrared dye which has been used clinically for several decades. Recently, it has been utilised for fluorescence-guided surgery in a range of solid cancer types, including sarcoma, with the...
Sparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer† [0.03%]
吸烟通过驱动三阴性乳腺癌干细胞样特性及上皮间质转化促进肿瘤恶性进展
Christopher Simpkins,Eneda Toska
Christopher Simpkins
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and HER2, and remains one of the most aggressive and therapeutically challenging breast cancer subtypes, marked by early relapse, m...
Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp [0.03%]
NLRP1和IL1B的遗传变异对妊娠期疟疾的影响：NLRP1在Plasmodium spp诱导的炎性小体活化中的作用不容忽视
Vinicius Nc Leal,Jessica A Ribeiro,Leticia Girardi Marra et al.
Vinicius Nc Leal et al.
We hypothesized that variants in inflammasome-related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria-endemic region in northern ...
Andrea Flesken-Nikitin,Matalin G Pirtz,Christopher S Ashe et al.
Andrea Flesken-Nikitin et al.
Serous endometrial carcinoma (SEC) is one of the most lethal types of uterine cancer, responsible for about 40% of all endometrial cancer-related deaths. Cell state dynamics during the early stages of SEC remain largely unknown, thereby hin...