Contrastive virtual staining enhances deep learning-based PDAC subtyping from H&E-stained tissue cores [0.03%]
对比虚拟染色增强基于H&E染色组织核心的胰腺导管腺癌亚型的深度学习方法
Maximilian Fischer,Alexander Muckenhuber,Robin Peretzke et al.
Maximilian Fischer et al.
Pancreatic ductal adenocarcinoma (PDAC) subtyping typically relies on immunohistochemistry (IHC) staining for critical markers like HNF1A and KRT81, a labor-intensive manual staining process that introduces variability. Virtual staining met...
mTOR-mediated upregulation of B7-H3 in MiT/TFE translocation renal cell carcinoma [0.03%]
MiT/TFE易位肾细胞癌中mTOR介导的B7-H3上调
Huili Li,Adrianna Amaral,Thiago Vidotto et al.
Huili Li et al.
Clinical trials targeting B7-H3 (CD276), a membranous immunomodulatory molecule in the B7 superfamily, have shown promise in prostate cancer and may be expanded to additional tumor types with high expression, such as those with mTOR signali...
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression [0.03%]
系谱分析配对乳腺癌鉴定与克隆复发和侵袭性进展相关的遗传事件
Tanjina Kader,Maia Zethoven,Sakshi Mahale et al.
Tanjina Kader et al.
Development of ipsilateral breast carcinoma following a diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not always be the case, and it is important to det...
MicroRNA profiling of testicular Leydig cell tumors identifies a microRNA signature associated with malignancy and miR-196b-5p as a potentially useful biomarker [0.03%]
微RNA谱分析发现曲细精管间质细胞肿瘤恶性转化相关微RNA标记及miR-196b-5p作为潜在生物标志物
João Lobo,Nuno Tiago Tavares,Fernanda Fernandes-Pontes et al.
João Lobo et al.
Approximately 10% of testicular Leydig cell tumors (LCTs) are clinically malignant and unresponsive to systemic treatment. Predicting their clinical behavior can be problematic because there are no biomarkers that can consistently discrimin...
Identification of actionable targets using DEPArray-based sorting of pure carcinoma and stromal populations from formalin-fixed paraffin-embedded tissues followed by shallow whole-genome sequencing [0.03%]
基于DEPArray的富集纯癌和间质细胞群体进行浅层全基因组测序以鉴定可操作靶点
Georgios Nteliopoulos,Evie Wren,Amelia Rushton et al.
Georgios Nteliopoulos et al.
Formalin-fixed paraffin-embedded (FFPE) tissue specimens represent precious resources for clinical genomic profiling studies, especially when coupled with comprehensive medical records. Even though next-generation sequencing (NGS) is an eff...
Issues and missed opportunities in lymph node assessment after neoadjuvant chemotherapy [0.03%]
新辅助化疗后淋巴结评估中的问题与缺失的机会
Lucy Ryan,Elena Provenzano,Anita Grigoriadis et al.
Lucy Ryan et al.
Assessment of axillary lymph nodes in breast cancer patients following neoadjuvant chemotherapy (NACT) is a crucial part of the clinical and pathological assessment of the disease and has prognostic and management implications. This, howeve...
Carmen Al Youssef,Mansour Alkobtawi,Rémi Safi et al.
Carmen Al Youssef et al.
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and is most often caused by cumulative UV exposure. However, cSCC may also arise independently of UV exposure, on sites of sustained skin damage like chronic ulc...
Fibroblast-specific palladin drives kidney fibrosis via MRTF-SRF signaling [0.03%]
成纤维细胞特异性Palladin通过MRTF-SRF信号促进肾纤维化
Naoki Yamamoto,Norihiko Sakai,Yuta Yamamura et al.
Naoki Yamamoto et al.
Fibrosis is a common end-stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin-related transcription factor (MRTF)-serum response factor (SRF) signaling drives the expression of fibrosis-related mol...
Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension [0.03%]
乳酸通过GPR81激活调控低氧条件下慢性髓性白血病细胞中BCR/Abl蛋白的表达
Giulio Menegazzi,Dayana Desideri,Alessio Biagioni et al.
Giulio Menegazzi et al.
Chronic myeloid leukemia (CML) is a stem cell-driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the ...
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts† [0.03%]
胰腺癌癌前病变的转化：简单黏液囊肿的作用
Paolo Riccardo Camisa,Daniele Campa,Irene Esposito et al.
Paolo Riccardo Camisa et al.
Pancreatic cystic lesions present a unique opportunity to identify and potentially prevent pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Until now, research has primarily focused on intraductal papillary mucino...