Small cell neuroendocrine carcinoma of the cervix: diagnostic challenges and emerging molecular insights† [0.03%]
宫颈小细胞神经内分泌癌的诊断挑战及分子新见解
Alphonse Charbel,Gaëlle Akiki,Sarah-Slim Diwan et al.
Alphonse Charbel et al.
Small cell neuroendocrine carcinoma of the cervix (SCNECC) is a rare and highly aggressive malignancy with poor prognosis that predominantly affects premenopausal women. Histopathological evaluation is central to diagnosis and clinical mana...
Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia [0.03%]
雌激素调节影响前列腺疾病 或可解释男性前列腺增生的种族差异性
Teresa T Liu,Laura E Pascal,Emily A Ricke et al.
Teresa T Liu et al.
Lower urinary tract symptoms (LUTS), associated with benign prostatic hyperplasia (BPH), are an aging-related disease, with more than 210 million cases worldwide. Estrogen exposure and estrogen regulation have been implicated in a variety o...
Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy [0.03%]
高ABCC2乳头状肾细胞癌显示免疫逃避型特征与良好的免疫治疗反应相关
Vincent Francis Castillo,Abraam Zakhary,Fabio Rotondo et al.
Vincent Francis Castillo et al.
The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset...
Novel growth pattern-specific digital marker of TILs improves stratification of lung adenocarcinoma patients [0.03%]
新颖的肿瘤浸润淋巴细胞生长模式特异性数字标记物可改善肺腺癌患者的分层治疗效果
Arwa AlRubaian,Ayesha Azam,Nasir M Rajpoot et al.
Arwa AlRubaian et al.
Lung adenocarcinoma (LUAD) is one of the most prevalent forms of cancer and continues to be associated with high mortality rates, despite recent advances in cancer therapy. Effective risk stratification is critical for guiding treatment dec...
Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation [0.03%]
乳腺癌易感基因+2T变异体非典要捐赠剪接位点的生成及其对临床解释的影响
Inés Llinares-Burguet,Lara Sanoguera-Miralles,Elena Bueno-Martínez et al.
Inés Llinares-Burguet et al.
Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5' splice sites (5'ss) are generally strong indicators of...
Clinical outcomes and immune contexture in SMARCA4-deficient gastric cancer patients [0.03%]
SMARCA4缺陷型胃癌患者的临床转归及其免疫微环境研究
Mengyao Sun,Yun Gu,Jieti Wang et al.
Mengyao Sun et al.
Exploiting vulnerabilities in switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes for cancer therapy is a promising therapeutic strategy. The SWI/SNF chromatin remodeling complex acts as a regulatory component of transcri...
Hypoxia-induced regional heterogeneity in proliferative vitreoretinopathy: implications for targeted therapies [0.03%]
缺氧诱导的增生性玻璃体视网膜病变区域性异质性的研究及其对靶向治疗的意义
Wenjie Yin,Miao Xu,Yan Gao et al.
Wenjie Yin et al.
Proliferative vitreoretinopathy (PVR) represents a common and challenging complication leading to blindness following ocular injury. The prevailing view, which guides current drug development efforts, posits that the mesenchymal transition ...
Molecular evidence of a clonal relationship of synchronous/multifocal gastric-type lesions of the female genital tract [0.03%]
女性生殖道同步/多发胃型病变克隆关系的分子证据
Min Shi,Hong Yang,Fang Zhang et al.
Min Shi et al.
Synchronous/multifocal gastric-type lesions (SMGLs) of the female genital tract are heterogeneous diseases that are rare and challenging to diagnose. The core issue is distinguishing between multiple primaries and multifocal metastases from...
Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease [0.03%]
转录组谱分析揭示Hedgehog信号传导作为Menetrier病生物标志物及在疾病发生发展中的作用
Miyoung Shin,Tryston T Gabriel,Fred Kwame Ofosu et al.
Miyoung Shin et al.
Both Ménétrier's disease (MD) and juvenile polyposis syndrome (JPS) are rare premalignant conditions that can lead to gastric cancer. MD is an acquired disease without known causative mutations that is characterized by increased expressio...