Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance [0.03%]
肺癌中的线粒体重构：一个治疗弱点及克服耐药性的策略
Woo Hyun Park
Woo Hyun Park
The conceptualization of mitochondria, previously restricted to their function as cellular 'powerhouses', has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and f...
Exploring adenoid basal carcinoma to squamous cell carcinoma of the uterine cervix transformation using spatial transcriptomics [0.03%]
利用空间转录组学探索宫颈腺基底细胞癌向鳞状细胞癌转化规律
Ruyi Ma,Yan Jin,Zhe Lei et al.
Ruyi Ma et al.
Adenoid basal carcinoma (ABC) is a rare cervical tumor that generally carries a favorable prognosis. However, when ABC is mixed with an invasive carcinoma, particularly squamous cell carcinoma (SCC), the prognosis is poor. Moreover, transit...
Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease [0.03%]
克罗恩病纤维化狭窄肠壁中血管丛与淋巴组织聚集体及固有肌层纤维化的共定位分布特点研究
Michael Glinka,Gregory J Wickham,Francesca Nadalin et al.
Michael Glinka et al.
Crohn's disease (CD) involves chronic transmural inflammation of the intestines, leading to progressive wall fibrosis with stenosis and luminal obstruction, predominantly in the terminal ileum. Fibrosis is a significant therapeutic challeng...
Roles of THBS2+ fibroblasts in malignant transformation of colorectal polyp to cancer [0.03%]
THBS2+纤维细胞在结直肠息肉恶性转化中的作用
Qizheng Han,Lu Liu,Jingyu Wang et al.
Qizheng Han et al.
Colorectal cancer (CRC) typically originates from benign polyps within the colorectum. However, the mechanisms driving this transformation remain poorly understood. In this study, we employed a comprehensive multi-omics approach, incorporat...
Characterisation of bacteria-induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease [0.03%]
细菌诱导的裸鼹鼠结肠炎的特征及其对益生菌的调节作用：急性炎症病的新哺乳动物模型
Daniel W Hart,Aik Seng Ng,Patrycja Gazińska et al.
Daniel W Hart et al.
Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobi...
Ariunbuyan Sukhbaatar,Mishra Radhika,Akira Nakamura et al.
Ariunbuyan Sukhbaatar et al.
Understanding the lymphatic network is crucial for immunological research. Currently, a complete map of lymphatic drainage in mice is lacking. We present a detailed lymphatic system flow dynamic of two mouse strains with swollen lymph nodes...
Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis [0.03%]
肝内胆管细胞癌合并胆道肿瘤栓（管内息肉样生长）的临床病理和基因组分析
Ayaka Mitsui,Minoru Esaki,Satoshi Nara et al.
Ayaka Mitsui et al.
Bile duct tumor thrombus (BDTT), a tumor cluster occupying the luminal space in the large bile duct, is rare in intrahepatic cholangiocarcinoma (iCCA). Most studies on BDTT in iCCA to date are case reports, and the clinicopathological chara...
Correction to 'Recombinant Klotho administration after myocardial infarction reduces ischaemic injury and arrhythmias by blocking intracellular calcium mishandling and CaMKII activation' [0.03%]
对“心肌梗死后给予重组Klotho可减少缺血损伤和心律失常：通过阻止细胞内钙处理异常和CaMKII激活”的修正
Published Erratum
The Journal of pathology. 2026 Jan 27. DOI:10.1002/path.70042 2026
Utility of pancreatic tumor scrapings for organoid development and precision medicine strategies [0.03%]
胰腺肿瘤刮片用于类器官培养及精准医疗的初步探索研究
Caitlin F Tsang,Hardik Patel,Fatim M Kouassi et al.
Caitlin F Tsang et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to late diagnosis and chemoresistance. Patient-derived organoids (PDOs) hold promise for predicting individualized drug responses, but their establishment is often ...
Hierarchical image pyramid transformer framework for automated breast cancer molecular subtyping using tissue microarrays [0.03%]
基于组织微阵列的乳腺癌分子亚型自动分类的层次图像金字塔变换器框架
Baizhou Li,Yuting Zhong,Zehang Xing et al.
Baizhou Li et al.
The heterogeneity of breast cancer at molecular and histological levels poses significant challenges for precise diagnosis and treatment. Current molecular subtyping, crucial for guiding personalized therapy, relies on immunohistochemistry,...