Integrated morphological, immunohistochemical, and genomic profiling identifies uterine leiomyoma patients with hereditary leiomyomatosis and renal cell cancer syndrome: a comprehensive analysis of 252 cases [0.03%]
整合形态学、免疫组化和基因组分析确定子宫肌瘤患者遗传性平滑肌瘤病和肾细胞癌综合征：252例综合分析
Yan Liu,Xiaoxi Wang,Yuxiang Wang et al.
Yan Liu et al.
Fumarate hydratase-deficient uterine leiomyomas (FHd-ULMs) represent a molecularly distinct subgroup of smooth muscle tumours associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. This study determined the detect...
Delta-like 1 homolog (DLK1) regulates cancer stemness and chemoresistance of ovarian cancer by CD44/CD133 upregulation [0.03%]
DLK1通过上调CD44/CD133调节卵巢癌的肿瘤干细胞特性及耐药性
Chao-Cheng Huang,Jian-Ching Wu,Pei-Chin Chen et al.
Chao-Cheng Huang et al.
Ovarian cancer is a heterogeneous gynecologic malignancy, with most cases diagnosed at an advanced stage. Despite the availability of effective treatments such as surgery and platinum/taxane-based chemotherapy, advanced ovarian cancer frequ...
ERBB2 amplification is a late event in the pathogenesis of high-grade endometrial carcinomas with heterogeneous HER2 expression [0.03%]
高grade子宫内膜癌异质性HER2表达的发病过程中的分子特征： erbB2扩增是一个晚期事件
Michael Herman Chui,David N Brown,Jorge S Reis-Filho et al.
Michael Herman Chui et al.
Intratumor heterogeneity of ERBB2 amplification/HER2 overexpression is frequently observed in ERBB2-amplified high-grade endometrial carcinoma (HG-EC) and contributes to anti-HER2 therapy resistance. To elucidate the molecular pathogenesis ...
Integration of histopathological characteristics by machine learning improves the prediction of neoadjuvant immunochemotherapy response in triple-negative breast cancer [0.03%]
机器学习整合组织病理特征可改善三阴性乳腺癌新辅助免疫化疗疗效预测能力
Xunxi Lu,Bin Luo,Yani Wei et al.
Xunxi Lu et al.
Neoadjuvant immunochemotherapy (NAIC) is a standard treatment for triple-negative breast cancer (TNBC), but there is no reliable biomarker to identify potential responders and optimize patient care. In this study, we developed a model named...
Fibroblast-derived neuropilin 1 alleviates renal fibrosis progression [0.03%]
成纤维细胞衍生的神经纤毛蛋白1可缓解肾纤维化进展
Yunzhu Shen,Sandrine Placier,Liliane Louedec et al.
Yunzhu Shen et al.
Chronic kidney disease (CKD) is a major global health challenge affecting over 10% of the adult population. A hallmark of CKD progression is the transdifferentiation of kidney fibroblasts into extracellular matrix-producing myofibroblasts, ...
Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell-of-origin model for osteoid osteoma and osteoblastoma [0.03%]
截短的FOS损害成骨分化并诱导软骨细胞和成骨细胞原代细胞中骨样骨瘤和成骨细胞瘤的细胞起源模型中的前列腺素和NFκB信号转导
Suk Wai Lam,Tatiana Belova,Natasja Franceschini et al.
Suk Wai Lam et al.
Osteoid osteoma and osteoblastoma are non-malignant bone-forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in...
Molecular alterations in high-grade neuroendocrine tumors of the small intestine [0.03%]
高度恶性的小肠神经内分泌肿瘤的分子改变
Agathe Hercent,Julien Masliah-Planchon,David Cohen et al.
Agathe Hercent et al.
High-grade neuroendocrine tumors of the small intestine are separated into two groups: well-differentiated neuroendocrine tumors (NETs, high-grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entitie...
Spatial analysis of HPV-associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression [0.03%]
空间分析表明与宫颈癌进展相关的HPV相关宫颈上皮内瘤样组织具有不同的免疫特征
Gianna Pavilion,Hani Vu,Zherui Xiong et al.
Gianna Pavilion et al.
Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV-related cancers continue to rise. For the development of effective prevention strategies in high-risk patients, we aimed to better ...
Genome-wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas [0.03%]
B1和B2型胸腺瘤的全基因组非编码突变模式及线粒体异质性分析
Kohei Fujikura,Isabel Correa,Susanne Heck et al.
Kohei Fujikura et al.
Type B1 and B2 thymomas are lymphocyte-rich malignant tumours with few somatic mutations in protein-coding regions of the nuclear genome; nonetheless, noncoding regions remain uncharacterized. Here, we developed a method to isolate pure thy...