Mining bulk transcriptomic datasets identifies inflammasome activation and antigen presentation as key novel mechanisms of BK polyomavirus-associated nephropathy [0.03%]
挖掘大规模转录组数据集识别出炎症小体激活和抗原呈递是BK多瘤病毒相关肾病的关键新机制
Lachlan A Davidson,Natalie M Niessen,Matthew Rowlandson et al.
Lachlan A Davidson et al.
BK polyomavirus (BKPyV) is a viral infection experienced by kidney transplant recipients that can lead to the development of BKPyV-associated nephropathy (BKPyVAN), graft dysfunction, and loss. There are no BKPyV-specific treatments availab...
Relative MYC downregulation and RUNX2 upregulation orchestrate partial epithelial-mesenchymal transition in colorectal cancer tumor budding and poorly differentiated clusters [0.03%]
MYC下调和RUNX2上调在结直肠癌肿瘤芽和分化不良簇的部分上皮间质转化中的协同作用
Tsuyuha Koba,Takashi Hibiya,Takahiro Shibayama et al.
Tsuyuha Koba et al.
Tumor budding and poorly differentiated clusters are key prognostic indicators in colorectal cancer, yet the molecular mechanisms underlying their formation remain incompletely characterized. Using the GeoMx Digital Spatial Profiler, we ana...
Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing [0.03%]
内藤顿综合征的蛋白酶级联失调：从分子病理学到临床前药物试验
Eleni Zingkou,Evangelos Bisyris,Georgios Pampalakis et al.
Eleni Zingkou et al.
Netherton syndrome (NS) is a rare, severe, and often life-threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a hi...
Uncovering the potential of pathomics: prognostic prediction and mechanistic investigation of pancreatic cancer [0.03%]
揭示路径组学的潜力：胰腺癌预后预测和机制研究
Long Liu,Xiaohong Zhao,Fabiao Zhang et al.
Long Liu et al.
A machine learning-based pathomics model was investigated for its value and biological significance in predicting overall survival (OS) after surgery in pancreatic cancer patients. Data from 173 patients with pancreatic ductal adenocarcinom...
Integrated morphological, immunohistochemical, and genomic profiling identifies uterine leiomyoma patients with hereditary leiomyomatosis and renal cell cancer syndrome: a comprehensive analysis of 252 cases [0.03%]
整合形态学、免疫组化和基因组分析确定子宫肌瘤患者遗传性平滑肌瘤病和肾细胞癌综合征：252例综合分析
Yan Liu,Xiaoxi Wang,Yuxiang Wang et al.
Yan Liu et al.
Fumarate hydratase-deficient uterine leiomyomas (FHd-ULMs) represent a molecularly distinct subgroup of smooth muscle tumours associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. This study determined the detect...
Delta-like 1 homolog (DLK1) regulates cancer stemness and chemoresistance of ovarian cancer by CD44/CD133 upregulation [0.03%]
DLK1通过上调CD44/CD133调节卵巢癌的肿瘤干细胞特性及耐药性
Chao-Cheng Huang,Jian-Ching Wu,Pei-Chin Chen et al.
Chao-Cheng Huang et al.
Ovarian cancer is a heterogeneous gynecologic malignancy, with most cases diagnosed at an advanced stage. Despite the availability of effective treatments such as surgery and platinum/taxane-based chemotherapy, advanced ovarian cancer frequ...
ERBB2 amplification is a late event in the pathogenesis of high-grade endometrial carcinomas with heterogeneous HER2 expression [0.03%]
高grade子宫内膜癌异质性HER2表达的发病过程中的分子特征： erbB2扩增是一个晚期事件
Michael Herman Chui,David N Brown,Jorge S Reis-Filho et al.
Michael Herman Chui et al.
Intratumor heterogeneity of ERBB2 amplification/HER2 overexpression is frequently observed in ERBB2-amplified high-grade endometrial carcinoma (HG-EC) and contributes to anti-HER2 therapy resistance. To elucidate the molecular pathogenesis ...
Integration of histopathological characteristics by machine learning improves the prediction of neoadjuvant immunochemotherapy response in triple-negative breast cancer [0.03%]
机器学习整合组织病理特征可改善三阴性乳腺癌新辅助免疫化疗疗效预测能力
Xunxi Lu,Bin Luo,Yani Wei et al.
Xunxi Lu et al.
Neoadjuvant immunochemotherapy (NAIC) is a standard treatment for triple-negative breast cancer (TNBC), but there is no reliable biomarker to identify potential responders and optimize patient care. In this study, we developed a model named...
Fibroblast-derived neuropilin 1 alleviates renal fibrosis progression [0.03%]
成纤维细胞衍生的神经纤毛蛋白1可缓解肾纤维化进展
Yunzhu Shen,Sandrine Placier,Liliane Louedec et al.
Yunzhu Shen et al.
Chronic kidney disease (CKD) is a major global health challenge affecting over 10% of the adult population. A hallmark of CKD progression is the transdifferentiation of kidney fibroblasts into extracellular matrix-producing myofibroblasts, ...
Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell-of-origin model for osteoid osteoma and osteoblastoma [0.03%]
截短的FOS损害成骨分化并诱导软骨细胞和成骨细胞原代细胞中骨样骨瘤和成骨细胞瘤的细胞起源模型中的前列腺素和NFκB信号转导
Suk Wai Lam,Tatiana Belova,Natasja Franceschini et al.
Suk Wai Lam et al.
Osteoid osteoma and osteoblastoma are non-malignant bone-forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in...