Immunological mechanisms underlying the clinical heterogeneity of Kikuchi disease: the potential role of atypical memory B cells [0.03%]
Kikuchi病临床异质性的免疫学机制：非典型记忆B细胞的潜在作用
Shan-Chi Yu,Kung-Chao Chang,Tseng-Cheng Chen et al.
Shan-Chi Yu et al.
Building on our previous research, which classified Kikuchi disease into three subtypes based on predominant symptoms and fever status - febrile type, febrile lymphadenopathy (FebLAP), and afebrile lymphadenopathy (aLAP) - we further invest...
Tubal ligation exacerbates ovulation-driven TP53 mutagenesis and p53 signatures by depleting protective menstrual hemoglobin [0.03%]
输卵管结扎通过耗尽保护性月经血红蛋白来加剧卵泡刺激驱动的TP53基因突变和p53信号转导路径
Kanchana Subramani,Cheng-Chuan Su,Jen-Hung Wang et al.
Kanchana Subramani et al.
The fallopian tube epithelium (FTE) is the primary tissue of origin for ovarian high-grade serous carcinoma (HGSC), with ovulation implicated as a key risk factor. TP53 mutations, a hallmark of HGSC and its precursor lesions, such as p53 si...
Topological analysis of the human lymph node reticular network predicts outcome in breast cancer [0.03%]
人体淋巴结网状网络的拓扑分析可预测乳腺癌预后
Amy M Llewellyn,Sharon L D&#x;Costa,Cheun Yr Lam et al.
Amy M Llewellyn et al.
Axillary LNs (ALNs) initiate immune responses in breast cancer (BC) but how and when ALNs become dysfunctional, facilitating metastasis, is unclear. The fibroblastic reticular cell (FRC) network within ALNs provides structural support and m...
Human induced pluripotent stem cell-derived chimeric antigen receptor-macrophages eradicate IL-13Rα2-positive solid tumors [0.03%]
人诱导多能干细胞系源性嵌合抗原受体巨噬细胞能够杀伤IL-13Rα2阳性实体肿瘤细胞
Ying Yang,Lujing Wang,Yi Zhang et al.
Ying Yang et al.
Macrophages exhibit extensive tumor infiltration capacity across diverse solid malignancies, establishing macrophage-targeted immunotherapies as an emerging frontier in oncology. Genetic engineering of macrophages using chimeric antigen rec...
Cellular origins and etiological factors for squamous cell carcinoma and related cancer types of the bladder [0.03%]
膀胱鳞细胞癌及相关的肿瘤类型的细胞起源和病因因素
Xianbin Su,Xuehui Duan,Shihao Bai et al.
Xianbin Su et al.
Squamous cell carcinoma (SCC) of the bladder is a rare disease with poor prognosis and limited molecular profiling. Here we present a multi-layer, comparative investigation on bladder SCC and related cancers, namely pure urothelial carcinom...
Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions [0.03%]
肺部疾病的内质网应激和未折叠蛋白反应：分子通路及治疗干预措施
Lanlan Song,Yichen Liu,Chen Xu et al.
Lanlan Song et al.
Endoplasmic reticulum stress (ERS) occurs when the protein-folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift...
Yukako Suzuki,Maolin Ge
Yukako Suzuki
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality, and many patients derive limited benefit from current systemic therapies. Until now, clinical and translational efforts have largely focused on recurrent genomi...
Tissue-level heterogeneity in FECD: Descemet's membrane phenotypes and association with TCF4 CTG18.1 expansion† [0.03%]
FECD的组织异质性：Descemet膜表型与TCF4 CTG18.1扩张的相关性
Sayo Maeno,Yoshinori Oie,Chifune Kai et al.
Sayo Maeno et al.
Late-onset Fuchs endothelial corneal dystrophy (FECD) is commonly framed as a corneal endothelial disease characterised by guttae accumulation and progressive thickening of Descemet's membrane (DM). However, clinical forms and evolutionary ...
Sangita P Patel
Sangita P Patel
Late-onset Fuchs endothelial corneal dystrophy (FECD) is characterized by distinct extracellular matrix deposits (guttae) within the basement membrane (Descemet's membrane) of the corneal endothelium. In a recent study published in The Jour...