Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer [0.03%]
嘌呤能受体P2RX4异常剪切可使结直肠癌和胰腺癌不敏感于联合疗法治疗
Christoph Steup,Julian Dosch,Christopher Dietz-Fricke et al.
Christoph Steup et al.
Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4-expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4...
CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells [0.03%]
肝细胞癌中的CLEC14A与中性粒细胞浸润相关，并介导中性粒细胞通过肝脏内皮细胞的募集作用
Joanne M O&#x;Rourke,Dean Kavanagh,Ayla O&#x;Keeffe et al.
Joanne M O&#x;Rourke et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune ...
Ajinkya R Limkar,Sophia M Vrba,Emily A Ricke et al.
Ajinkya R Limkar et al.
Benign prostatic hyperplasia (BPH) is a widely prevalent age-associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH path...
Histiocytosis development and clinical variation through the lens of genomics [0.03%]
基因组学视角下的朗格汉斯细胞组织细胞增生症的发病机制及其临床异质性
Paul G Kemps,Astrid Gs van Halteren,Tom van Wezel et al.
Paul G Kemps et al.
Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive...
Lymph node stromal topology as a hidden regulator of breast cancer outcome: commentary on reticular network analysis† [0.03%]
淋巴结基质拓扑结构作为影响乳腺癌预后的潜在调节因素：关于网状网络分析的评论
Andrea Vethencourt,Roberto Salgado,Eva Gonzalez-Suarez
Andrea Vethencourt
The axillary lymph node remains a cornerstone of breast cancer staging and therapeutic decision-making, yet it is still largely interpreted through a static anatomical framework. Emerging evidence challenges this paradigm, positioning tumor...
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis [0.03%]
内源大麻素信号转导障碍导致急性胰腺炎系统性炎症反应失控
Paula Goncalves-Romeu,Karina Cárdenas-Jaen,Enrique de-Madaria et al.
Paula Goncalves-Romeu et al.
Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabino...
Testican-1-MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective [0.03%]
肿瘤细胞外基质重塑中testican-1-mmp轴的作用机制及计算视角下的相互作用动力学分析
Sepideh Youssefi,Kiarash Saleki,Prerna Kadam et al.
Sepideh Youssefi et al.
The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican-1 (SPOCK1), an excretory matricellular proteog...
Identifying therapeutic targets in low-grade serous ovarian carcinomas with no specific molecular profile [0.03%]
识别低级别浆液性卵巢癌中的治疗靶点（无特异性分子特征）
Kathleen I Pishas,Karla J Cowley,Evanny Marinovic et al.
Kathleen I Pishas et al.
Low-grade serous ovarian carcinoma (LGSOC) is a rare, indolent ovarian cancer subtype with limited effective therapies. Approximately 40% of cases lack canonical MAPK/ERK or PI3K/AKT/mTOR pathway alterations and are classified as having no ...
Anna Kc Wong,Vinotheni Rajendran,Lucia Mundo et al.
Anna Kc Wong et al.
It is widely recognized that latent infection is the predominant mode of Epstein-Barr virus (EBV) infection in nasopharyngeal carcinoma (NPC) in which a specific set of latent genes is responsible for driving the development of the disease....
Mikhail S Ermakov,Juliana Faria Filipe,Sylvia Eidenhammer et al.
Mikhail S Ermakov et al.
Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We inves...