Genomic landscape and homologous recombination deficiency in malignant germ cell tumors reveals sex-specific therapeutic opportunities [0.03%]
恶性生殖细胞肿瘤的基因组景观和同源重组缺陷显示了性别特异性的治疗机会
Boheng Xu,Jiahong Chen,Huiting Peng et al.
Boheng Xu et al.
Malignant germ cell tumors (GCTs) are relatively rare tumors with limited therapeutic options. This study examined the homologous recombination deficiency (HRD) status and genomic characteristics in 14 patients with GCT who underwent next-g...
Neutrophil extracellular traps aggravate lung injury by inducing pyroptosis of alveolar macrophages [0.03%]
中性粒细胞胞外诱捕网通过诱导肺泡巨噬细胞焦亡加重肺损伤
Junjuan Lu,Rouxi Song,Honghui Yang et al.
Junjuan Lu et al.
Neutrophil extracellular traps (NETs) contribute to chronic obstructive pulmonary disease (COPD) pathogenesis by amplifying airway inflammation. Gasdermin D (GSDMD)-mediated pyroptosis is a critical driver of COPD progression. This study pr...
Clinicopathological characteristics of patients with inoperable non-small cell lung cancer harboring circulating NRF2 pathway mutations [0.03%]
不可手术非小细胞肺癌患者中携带循环NRF2通路突变的临床病理特征分析
Jouni Härkönen,Satu Tiainen,Jouni Kujala et al.
Jouni Härkönen et al.
Lung cancer is the leading cause of global cancer-related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2-related factor 2 (NRF2) is a redox-regulated transcription factor frequently dy...
Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats [0.03%]
Fuchs角膜内皮营养不良的病理分类及其与CTG18.1扩增重复序列的关系
Hanielle Vaitinadapoulé,Daria Onitiu,Corantin Maurin et al.
Hanielle Vaitinadapoulé et al.
Late-onset Fuchs endothelial corneal dystrophy (FECD) is the most common primary disease of the corneal endothelium and the leading indication for corneal transplantation in Western countries. It is characterized by progressive accumulation...
What practicing pathologists and oncologists should know about the new computational pathology-based companion diagnostic tools [0.03%]
病理学家和肿瘤学家应该了解的基于计算病理学的新型伴随诊断工具的相关知识
Diana Montezuma,Sara P Oliveira,Inti Zlobec et al.
Diana Montezuma et al.
The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most...
Deep learning-based H&E-derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response [0.03%]
基于深度学习的结直肠癌H&E衍生风险评分与其肿瘤形态、生物学和预测药物反应的相关性
Nic G Reitsam,Xiaofeng Jiang,Junhao Liang et al.
Nic G Reitsam et al.
Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)-stained routine whole-slide images (WSIs). Unlike traditional studies th...
Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness [0.03%]
前列腺周围脂肪组织扩张的独特机制：对前列腺癌侵袭性的意义
David Estève,Aurélie Toulet,Mathieu Roumiguié et al.
David Estève et al.
One of the most striking features of the adipose depot surrounding the prostate [periprostatic adipose tissue (PPAT)] is that its accumulation is independent of body mass index. Its volume varies considerably between individuals, with some ...
Clinicopathological significance of loss of Y chromosome in male meningiomas [0.03%]
男性脑膜瘤中Y染色体丢失的临床病理意义
Maki Sakaguchi,Masafumi Horie,Yukinobu Ito et al.
Maki Sakaguchi et al.
Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high-grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in var...
Xenium-based spatial transcriptomic analyses uncover prognosis-associated heterogeneity in the tumor microenvironment (TME) of angioimmunoblastic T-cell lymphoma (AITL) [0.03%]
基于Xenium的空间转录组学分析揭示了血管免疫母T细胞淋巴瘤(TME)中与预后相关的异质性
Jiyan Dong,Xiaoyue Xiao,Lin Nong et al.
Jiyan Dong et al.
Angioimmunoblastic T-cell lymphoma (AITL) exemplifies a neoplasm characterized by prominent inflammatory infiltration and robust immune responses in the tumor microenvironment (TME). The pathophysiology of refractory/recurrent (RR) AITL rem...
Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium-chrysin target in breast carcinoma [0.03%]
脂肪酸和半胱氨酸代谢的相互作用调节铁死亡并突显了塞来昔特作为乳腺癌中硒-芹菜素靶点的作用
Ana Hipólito,Bruna Abreu,Joana Gonçalves et al.
Ana Hipólito et al.
Cancer metabolic remodeling impacts the entire network of metabolic pathways, and strategies that target various points within this system could contribute to successfully abrogating cancer cell survival. Fatty acids (FAs) are essential to ...