Spatial analysis of microRNA regulation at defined tumor hypoxia levels reveals biological traits of aggressive prostate cancer [0.03%]
空间分析定义的肿瘤缺氧水平下的微小核糖核酸调节揭示了侵袭性前列腺癌的生物学特征
Vilde E Skingen,Unn Beate Salberg,Tord Hompland et al.
Vilde E Skingen et al.
Mechanisms regulating the gene expression program at different hypoxia severity levels in patient tumors are not understood. We aimed to determine microRNA (miRNA) regulation of this program at defined hypoxia levels from moderate to severe...
TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential [0.03%]
端粒酶逆转录酶(TERT)的上调通过降解p21促进细胞增殖并增加致癌潜能
Masako Mishima,Atsushi Takai,Haruhiko Takeda et al.
Masako Mishima et al.
Telomerase reverse transcriptase (TERT) gene aberration is detectable in >80% of cases with hepatocellular carcinoma (HCC). TERT reactivation is essential for cellular immortalization because it stabilizes telomere length, although the role...
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features [0.03%]
Myxofibrosarcoma和未分化多形性肉瘤的转录组特征与临床及基因组特征相关
Shamik Mitra,Akanksha Farswan,Paul Piccinelli et al.
Shamik Mitra et al.
Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was to assess potential transcriptomic differences between MFS and UPS tumours and to...
Multicenter Study
The Journal of pathology. 2024 Nov;264(3):293-304. DOI:10.1002/path.6347 2024
Common progenitor origin for Rosai-Dorfman disease and clear cell sarcoma [0.03%]
Rosai-Dorf病与透明细胞肉瘤的共同祖细胞起源
Aki Sato,Nozomi Yusa,Hiroyuki Takamori et al.
Aki Sato et al.
Histiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While a proportion of coexisting HNs and haematological malignancies share identical genet...
Case Reports
The Journal of pathology. 2024 Nov;264(3):243-249. DOI:10.1002/path.6345 2024
Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease [0.03%]
单细胞转录组揭示WT1肾脏疾病早期阶段肾小球异常血管生成信号
Jennifer C Chandler,Daniyal J Jafree,Saif Malik et al.
Jennifer C Chandler et al.
WT1 encodes a podocyte transcription factor whose variants can cause an untreatable glomerular disease in early childhood. Although WT1 regulates many podocyte genes, it is poorly understood which of them are initiators in disease and how t...
Single-cell transcriptomic analysis reveals that the APP-CD74 axis promotes immunosuppression and progression of testicular tumors [0.03%]
单细胞转录组分析揭示APP-CD74轴促进睾丸肿瘤免疫抑制和进展
Guo Chen,Wei Wang,Xin Wei et al.
Guo Chen et al.
Testicular tumors represent the most common malignancy among young men. Nevertheless, the pathogenesis and molecular underpinning of testicular tumors remain largely elusive. We aimed to delineate the intricate intra-tumoral heterogeneity a...
Jennifer X Ji,Lien N Hoang,Dawn R Cochrane et al.
Jennifer X Ji et al.
Clear cell ovarian carcinoma (CCOC) is an aggressive malignancy affecting younger women. Despite ovarian cancer subtypes having diverse molecular and clinical characteristics, the mainstay of treatment for advanced stage disease remains cyt...
Spatial effects of infiltrating T cells on neighbouring cancer cells and prognosis in stage III CRC patients [0.03%]
浸润T细胞对结直肠癌三期患者邻近癌细胞的空间效应及其预后影响研究
Mohammadreza Azimi,Sanghee Cho,Emir Bozkurt et al.
Mohammadreza Azimi et al.
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate in more detail the spatial relationship ...
NMRK2 is an efficient diagnostic indicator for Xp11.2 translocation renal cell carcinoma [0.03%]
NMRK2是Xp11.2易位性肾细胞癌的高效诊断标志物
Huayi Feng,Shouqing Cao,Shihui Fu et al.
Huayi Feng et al.
Xp11.2 translocation renal cell carcinomas (tRCC) are a rare and highly malignant type of renal cancer, lacking efficient diagnostic indicators and therapeutic targets. Through the analysis of public databases and our cohort, we identified ...
Changes in the tumour microenvironment mark the transition from serous borderline tumour to low-grade serous carcinoma [0.03%]
肿瘤微环境的改变标志着粘液性borderline瘤向低级别粘液性癌的转变
Rodrigo Vallejos,Almira Zhantuyakova,Gian Luca Negri et al.
Rodrigo Vallejos et al.
Low-grade serous ovarian carcinoma (LGSC) is a rare and lethal subtype of ovarian cancer. LGSC is pathologically, biologically, and clinically distinct from the more common high-grade serous ovarian carcinoma (HGSC). LGSC arises from serous...