Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness [0.03%]
前列腺周围脂肪组织扩张的独特机制：对前列腺癌侵袭性的意义
David Estève,Aurélie Toulet,Mathieu Roumiguié et al.
David Estève et al.
One of the most striking features of the adipose depot surrounding the prostate [periprostatic adipose tissue (PPAT)] is that its accumulation is independent of body mass index. Its volume varies considerably between individuals, with some ...
Clinicopathological significance of loss of Y chromosome in male meningiomas [0.03%]
男性脑膜瘤中Y染色体丢失的临床病理意义
Maki Sakaguchi,Masafumi Horie,Yukinobu Ito et al.
Maki Sakaguchi et al.
Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high-grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in var...
Xenium-based spatial transcriptomic analyses uncover prognosis-associated heterogeneity in the tumor microenvironment (TME) of angioimmunoblastic T-cell lymphoma (AITL) [0.03%]
基于Xenium的空间转录组学分析揭示了血管免疫母T细胞淋巴瘤(TME)中与预后相关的异质性
Jiyan Dong,Xiaoyue Xiao,Lin Nong et al.
Jiyan Dong et al.
Angioimmunoblastic T-cell lymphoma (AITL) exemplifies a neoplasm characterized by prominent inflammatory infiltration and robust immune responses in the tumor microenvironment (TME). The pathophysiology of refractory/recurrent (RR) AITL rem...
Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium-chrysin target in breast carcinoma [0.03%]
脂肪酸和半胱氨酸代谢的相互作用调节铁死亡并突显了塞来昔特作为乳腺癌中硒-芹菜素靶点的作用
Ana Hipólito,Bruna Abreu,Joana Gonçalves et al.
Ana Hipólito et al.
Cancer metabolic remodeling impacts the entire network of metabolic pathways, and strategies that target various points within this system could contribute to successfully abrogating cancer cell survival. Fatty acids (FAs) are essential to ...
High-grade endometrial stromal sarcoma is closely related to BCOR-altered sarcomas of the soft tissue and kidney rather than to other uterine sarcomas: implications for uterine sarcoma classification [0.03%]
高级子宫内膜间质肉瘤与软组织和肾脏BCOR改变的肉瘤密切相关，而不是与其他子宫肉瘤相关：对子宫肉瘤分类的意义
Damiano Arciuolo,Sara Patrizi,Rita Alaggio et al.
Damiano Arciuolo et al.
High-grade endometrial stromal sarcoma (HGESS), which was not recognized as a distinct entity in the third edition of the World Health Organization (WHO) classification and was therefore included in the undifferentiated uterine sarcoma (UUS...
The immune-metabolism interactome in efferocytosis: a new paradigm for the central nervous system diseases revealed by single-cell sequencing analysis [0.03%]
单细胞测序揭示的摄取 apoptotic cells过程中免疫代谢互作网络：中枢神经系统疾病的新范式
Huiyi Zhang,Wenbin Li,Peilun Xiao et al.
Huiyi Zhang et al.
Efferocytosis is a process that maintains tissue homeostasis by removing apoptotic cells (ACs) by professional or non-professional phagocytes. The intricate process can be categorized into recognition of ACs, engulfment of ACs, and degradat...
Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance [0.03%]
肺癌中的线粒体重构：一个治疗弱点及克服耐药性的策略
Woo Hyun Park
Woo Hyun Park
The conceptualization of mitochondria, previously restricted to their function as cellular 'powerhouses', has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and f...
Exploring adenoid basal carcinoma to squamous cell carcinoma of the uterine cervix transformation using spatial transcriptomics [0.03%]
利用空间转录组学探索宫颈腺基底细胞癌向鳞状细胞癌转化规律
Ruyi Ma,Yan Jin,Zhe Lei et al.
Ruyi Ma et al.
Adenoid basal carcinoma (ABC) is a rare cervical tumor that generally carries a favorable prognosis. However, when ABC is mixed with an invasive carcinoma, particularly squamous cell carcinoma (SCC), the prognosis is poor. Moreover, transit...
Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease [0.03%]
克罗恩病纤维化狭窄肠壁中血管丛与淋巴组织聚集体及固有肌层纤维化的共定位分布特点研究
Michael Glinka,Gregory J Wickham,Francesca Nadalin et al.
Michael Glinka et al.
Crohn's disease (CD) involves chronic transmural inflammation of the intestines, leading to progressive wall fibrosis with stenosis and luminal obstruction, predominantly in the terminal ileum. Fibrosis is a significant therapeutic challeng...
Roles of THBS2+ fibroblasts in malignant transformation of colorectal polyp to cancer [0.03%]
THBS2+纤维细胞在结直肠息肉恶性转化中的作用
Qizheng Han,Lu Liu,Jingyu Wang et al.
Qizheng Han et al.
Colorectal cancer (CRC) typically originates from benign polyps within the colorectum. However, the mechanisms driving this transformation remain poorly understood. In this study, we employed a comprehensive multi-omics approach, incorporat...