Immune dysregulation in the prostates of C57BL/6Aire-/- mice mirrors that seen in human benign prostatic hyperplasia [0.03%]
C57BL/6Aire-/-小鼠前列腺免疫调节异常与人类良性前列腺增生相似
Nadia A Lanman,Meaghan M Broman,Harish Kothandaraman et al.
Nadia A Lanman et al.
Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remo...
Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of '-mabs'? [0.03%]
免疫检查点抑制剂治疗前列腺癌无效只是因为缺乏抗体药物吗？
Giuseppe Schepisi,Irene Torresan,Emilio Francesco Giunta et al.
Giuseppe Schepisi et al.
Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventua...
Bronchiolar adenoma-like lesions with atypical features beyond the classic morphological spectrum: integrating histomorphology and molecular profiles [0.03%]
超越经典形态谱的不典型支气管腺瘤样病变：结合组织形态和分子特征分析
Jiayu Li,Yunzhu Li,Yanqin Tan et al.
Jiayu Li et al.
Bronchiolar adenoma (BA) is a rare benign pulmonary neoplasm defined by a bilayered architecture with a continuous basal cell layer. Increasingly, BA-like lesions with atypical features have been recognized, challenging established diagnost...
Differences between mitotically old and young endometrial tumors [0.03%]
关于复制年龄较大的子宫内膜肿瘤与年轻的子宫内膜肿瘤的区别研究
Kellie Kim,Darryl Shibata
Kellie Kim
Human tumors likely differ in their mitotic ages, reflecting how many divisions elapse between the final tumor progenitor cell and surgical removal. We used a rapidly fluctuating CpG (fCpG) methylation clock to infer relative endometrial ad...
Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours [0.03%]
管状胃肠道肿瘤的知识缺口：世界卫生组织肿瘤分类第六版的批判性评估
Iris D Nagtegaal,Elizabeth A Montgomery,Alexandros D Polydorides et al.
Iris D Nagtegaal et al.
Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, ...
Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights [0.03%]
结直肠癌肿瘤浸润边界的形态学与分子特征：Tumor Invasive Border Index (TIBI)研究
Akseli Kehusmaa,Jouni Härkönen,Huayi Li et al.
Akseli Kehusmaa et al.
Tumor border configuration influences colorectal cancer (CRC) prognosis, yet its molecular determinants remain unclear and existing assessment criteria have faced challenges with reproducibility. We introduce the Tumor Invasive Border Index...
Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis [0.03%]
Wnt/脂生成轴在皮肤纤维化过程中介导脂肪营养不良和脂肪组织恢复
Suneeti R Madhavan,Piper Moore,Rohan Varshney et al.
Suneeti R Madhavan et al.
Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are ...
Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease [0.03%]
光学图谱绘制揭示了一个家族中大型结构变异的更高水平，该家族患有父系传递的肌萎缩症和独立的帕金森病
Md Mehedi Hasan,Jenna Craddock,Tingting Gong et al.
Md Mehedi Hasan et al.
Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine-thymine-guanine repeat expansio...
FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma [0.03%]
脂肪肉瘤素介导的蛋白二硫键异构酶m6A修饰激活VEGFA-VEGFR2以抑制成骨细胞凋亡
Jiashi Wang,Yingying Hao,Ming He et al.
Jiashi Wang et al.
Osteosarcoma (OS) is a primary bone malignancy, and its progression can be hindered by inducing programmed cell death (PCD). Protein disulfide-isomerase (PDI) regulates cancer cell death; however, its functional role in OS remains unclear. ...
Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model [0.03%]
多巴胺通过抑制视网膜病理性新生血管化防治氧诱导性视网膜病变小鼠模型氧化应激反应
Qi Wang,Jiajia Shi,Shuai Ouyang et al.
Qi Wang et al.
Pathological neovascularization is the leading cause of childhood blindness in retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor agents are commonly used to treat this condition, yet their variable efficacy and off-t...