Ajinkya R Limkar,Sophia M Vrba,Emily A Ricke et al.
Ajinkya R Limkar et al.
Benign prostatic hyperplasia (BPH) is a widely prevalent age-associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH path...
Histiocytosis development and clinical variation through the lens of genomics [0.03%]
基因组学视角下的朗格汉斯细胞组织细胞增生症的发病机制及其临床异质性
Paul G Kemps,Astrid Gs van Halteren,Tom van Wezel et al.
Paul G Kemps et al.
Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive...
Lymph node stromal topology as a hidden regulator of breast cancer outcome: commentary on reticular network analysis† [0.03%]
淋巴结基质拓扑结构作为影响乳腺癌预后的潜在调节因素：关于网状网络分析的评论
Andrea Vethencourt,Roberto Salgado,Eva Gonzalez-Suarez
Andrea Vethencourt
The axillary lymph node remains a cornerstone of breast cancer staging and therapeutic decision-making, yet it is still largely interpreted through a static anatomical framework. Emerging evidence challenges this paradigm, positioning tumor...
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis [0.03%]
内源大麻素信号转导障碍导致急性胰腺炎系统性炎症反应失控
Paula Goncalves-Romeu,Karina Cárdenas-Jaen,Enrique de-Madaria et al.
Paula Goncalves-Romeu et al.
Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabino...
Testican-1-MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective [0.03%]
肿瘤细胞外基质重塑中testican-1-mmp轴的作用机制及计算视角下的相互作用动力学分析
Sepideh Youssefi,Kiarash Saleki,Prerna Kadam et al.
Sepideh Youssefi et al.
The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican-1 (SPOCK1), an excretory matricellular proteog...
Identifying therapeutic targets in low-grade serous ovarian carcinomas with no specific molecular profile [0.03%]
识别低级别浆液性卵巢癌中的治疗靶点（无特异性分子特征）
Kathleen I Pishas,Karla J Cowley,Evanny Marinovic et al.
Kathleen I Pishas et al.
Low-grade serous ovarian carcinoma (LGSOC) is a rare, indolent ovarian cancer subtype with limited effective therapies. Approximately 40% of cases lack canonical MAPK/ERK or PI3K/AKT/mTOR pathway alterations and are classified as having no ...
Anna Kc Wong,Vinotheni Rajendran,Lucia Mundo et al.
Anna Kc Wong et al.
It is widely recognized that latent infection is the predominant mode of Epstein-Barr virus (EBV) infection in nasopharyngeal carcinoma (NPC) in which a specific set of latent genes is responsible for driving the development of the disease....
Mikhail S Ermakov,Juliana Faria Filipe,Sylvia Eidenhammer et al.
Mikhail S Ermakov et al.
Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We inves...
Unraveling the spatial landscape of dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophies [0.03%]
Duchenne和Becker型肌营养不良的转录组学方法解析 Duchenne和Becker型肌营养不良的空间景观解析
Laura Gm Heezen,Qirong Mao,Stefan Nicolau et al.
Laura Gm Heezen et al.
Dystrophinopathies are caused by pathogenic variants in the DMD gene, resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD) are characterized by progressive muscle wastin...
Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular-like pleomorphic adenoma [0.03%]
管状腺瘤与HMGA2::WIF1基因重排的类似管状多形性腺瘤的转录组比较研究
Ziyad Alsugair,Anne Champagnac,Maxime Fieux et al.
Ziyad Alsugair et al.
Canalicular adenoma (CA) is a benign salivary gland tumor predominantly affecting the upper lip and is characterized by monomorphic epithelial cells arranged in branching cords within a loose and vascularized stroma. Unlike pleomorphic aden...