Multi-omics analysis unveils the role of inflammatory cancer-associated fibroblasts in chordoma progression [0.03%]
多组学分析揭示了炎症性癌相关成纤维细胞在软骨肉瘤进展中的作用
Bo-Wen Zheng,Wei Guo
Bo-Wen Zheng
Cancer-associated fibroblasts (CAFs) constitute the primary cellular component of the stroma in chordomas, characterized by an abundance of mucinous stromal elements, potentially facilitating their initiation and progression; however, this ...
Intravenous iron treatment fuels chronic kidney disease-induced arterial media calcification in rats [0.03%]
静脉铁治疗可促进慢性肾脏病诱导的Sprague-Dawley大鼠动脉中膜钙化
Astrid Van den Branden,Britt Opdebeeck,Saar Adriaensen et al.
Astrid Van den Branden et al.
Arterial media calcification is a severe cardiovascular complication commonly manifesting in patients with chronic kidney disease (CKD). Patients with CKD frequently undergo intravenous iron therapy to address iron deficiency. Iron is sugge...
LINE-1 hypomethylation characterizes the inflammatory response in coeliac disease associated-intestinal mucosa and small bowel adenocarcinomas [0.03%]
线粒体DNA甲基化与炎症性肠病及小肠腺癌的关系研究
Laura Libera,Alessandro Vanoli,Nora Sahnane et al.
Laura Libera et al.
Long interspersed nuclear elements 1 (LINE-1) are the most abundant and the only autonomous mobile elements in the human genome. When their epigenetic repression is removed, it can lead to disease, such as autoimmune diseases and cancer. Co...
Proteomic analysis of non-muscle invasive and muscle invasive bladder cancer highlights distinct subgroups with metabolic, matrisomal, and immune hallmarks and emphasizes importance of the stromal compartment [0.03%]
蛋白质组分析发现非肌层浸润性和肌层浸润性膀胱癌具有代谢、基质和免疫特征的亚群，并强调了间质区隔的重要性
Thien-Ly Julia Dinh,Manuel Rogg,Miguel Cosenza-Contreras et al.
Thien-Ly Julia Dinh et al.
We present the proteomic profiling of 79 bladder cancers, including treatment-naïve non-muscle-invasive bladder cancer (NMIBC, n = 17), muscle-invasive bladder cancer (MIBC, n = 51), and neoadjuvant-treated MIBC (n = 11). Proteins were ext...
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning [0.03%]
小鼠Kcnd3 F227del突变导致脊髓小脑共济失调22型（SCA22）的机制研究：通过损害内质网和高尔基体功能产生显性负效应
Hao-Chih Hung,Jia-Han Lin,Yuan-Chi Teng et al.
Hao-Chih Hung et al.
Spinocerebellar ataxia type 22 (SCA22) caused by KCND3 mutations is an autosomal dominant disorder. We established a mouse model carrying the Kcnd3 F227del mutation to study the molecular pathogenesis. Four findings were pinpointed. First, ...
AMIGO2 characterizes cancer-associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes [0.03%]
AMIGO2在转移性结肠癌中表征癌症相关成纤维细胞并诱导旁分泌活性肿瘤生成(secretome)释放
Yongsong Yong,Richard Demmler,Bisan Abdalfatah Zohud et al.
Yongsong Yong et al.
Secretomes of cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretome...
Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophy [0.03%]
分泌硫酸软骨素蛋白聚糖-4的巨噬细胞可诱发杜氏肌营养不良症的神经心脏连接障碍
Marika Milan,Fabio Maiullari,Maila Chirivì et al.
Marika Milan et al.
Duchenne muscular dystrophy (DMD) is caused by the absence of the full form of the dystrophin protein, which is essential for maintaining the structural integrity of muscle cells, including those in the heart and respiratory system. Despite...
Runt-related transcription factor 1 (RUNX1) is a mediator of acute kidney injury [0.03%]
运行相关转录因子1(RUNX1)是急性肾损伤的介体
Miguel Fontecha-Barriuso,Natalia Villar-Gomez,Juan Guerrero-Mauvecin et al.
Miguel Fontecha-Barriuso et al.
Treatment for acute kidney injury (AKI) is suboptimal. A better understanding of the pathogenesis of AKI may lead to new therapeutic approaches. Kidney transcriptomics of folic acid-induced AKI (FA-AKI) in mice identified Runx1 as the most ...
Exploring the molecular landscape of cutaneous mixed tumors characterized by TRPS1::PLAG1 gene fusion [0.03%]
探索由TRPS1::PLAG1基因融合特征的皮肤混合肿瘤分子景观
Ziyad Alsugair,Marie Donzel,Nicolas Macagno et al.
Ziyad Alsugair et al.
The histological similarities between pleomorphic adenomas (PAs) and cutaneous mixed tumors (CMTs) found in certain facial regions can create a diagnostic challenge. Molecular findings reveal common genetic profiles, particularly PLAG1 rear...
Anti-VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis [0.03%]
抗VEGFR2中和抗体减缓多阶段口腔癌变的进程
Yoichiro Shirogane,Yu Usami,Masashi Okumura et al.
Yoichiro Shirogane et al.
Angiogenesis plays an important role in cancer growth and metastasis, and it is considered a therapeutic target to control tumour growth following anti-angiogenic therapy. However, it is still unclear when tissues initiate angiogenesis duri...