Extracellular matrix cancer-associated fibroblasts promote stromal fibrosis and immune exclusion in triple-negative breast cancer [0.03%]
细胞外基质癌相关成纤维细胞促进三阴性乳腺癌间质纤维化和免疫排斥
Xunxi Lu,Zongchao Gou,Hong Chen et al.
Xunxi Lu et al.
The impact of high heterogeneity of cancer-associated fibroblasts (CAFs) on triple-negative breast cancer (TNBC) immunotherapy response has not been fully elucidated, restricting progress in precision immuno-oncology. We integrated single-c...
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues [0.03%]
评估空间测序和成像方法以捕获存档的癌症组织中的分子和病理异质性
Tuan Vo,P Prakrithi,Kahli Jones et al.
Tuan Vo et al.
Spatial transcriptomics (ST) offers enormous potential to decipher the biological and pathological heterogeneity in precious archival cancer tissues. Traditionally, these tissues have rarely been used and only examined at a low throughput, ...
CHIT1 regulates the neuroinflammation and phagocytosis of microglia and suppresses Aβ plaque deposition in Alzheimer's disease [0.03%]
CHIT1调节小胶质细胞的神经炎症和吞噬作用并抑制阿尔茨海默病中的Aβ斑沉积
Shiyun Yuan,Fuxin Zhong,Tianchi Wan et al.
Shiyun Yuan et al.
Chitinase 1 (CHIT1), as a chitin-specific hydrolase, significantly influences the progression of Alzheimer's disease (AD) through microglia-associated inflammation and amyloid beta (Aβ) plaque accumulation. However, the precise mechanism o...
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy [0.03%]
人类和犬的口鼻黏膜黑色素瘤分为两种转录亚型对诊断及治疗具有重要意义
Kelly L Bowlt Blacklock,Kevin Donnelly,Yuting Lu et al.
Kelly L Bowlt Blacklock et al.
Mucosal melanoma is a rare melanoma subtype associated with a poor prognosis and limited existing therapeutic interventions, in part due to a lack of actionable targets and translational animal models for preclinical trials. Comprehensive d...
Recombinant Klotho administration after myocardial infarction reduces ischaemic injury and arrhythmias by blocking intracellular calcium mishandling and CaMKII activation [0.03%]
血管损伤后 administration of Recombinant Klotho通过阻断细胞内钙离子处理异常和CaMKII活化来减少缺血性损伤和心律失常
Sara Vázquez-Sánchez,Ana Blasco,Pablo Fernández-Corredoira et al.
Sara Vázquez-Sánchez et al.
Ischaemic heart disease (IHD) remains a major cause of death and morbidity. Klotho is a well-known anti-ageing factor with relevant cardioprotective actions, at least when renal dysfunction is present, but its actions are much less known wh...
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered mouse models [0.03%]
Pax3::Foxo1表达和发育谱系影响遗传工程小鼠模型横纹肌肉瘤肿瘤中的DNA甲基化模式
Wenyue Sun,Stephen M Hewitt,Hollis Wright et al.
Wenyue Sun et al.
Rhabdomyosarcoma (RMS) is a family of phenotypically myogenic paediatric cancers consisting of two major subtypes: fusion-positive (FP) RMS, most commonly involving the PAX3::FOXO1 fusion gene, formed by the fusion of paired box 3 (PAX3) an...
Dynamic change of polarity in spread through air spaces of pulmonary malignancies [0.03%]
肺部恶性肿瘤经气腔播散过程中极性的动态变化
Yoshiaki Matsuura,Kunishige Onuma,Roberto Coppo et al.
Yoshiaki Matsuura et al.
Spread through air spaces (STAS) is a histological finding of lung tumours where tumour cells exist within the air space of the lung parenchyma beyond the margin of the main tumour. Although STAS is an important prognostic factor, the patho...
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1 [0.03%]
沉默GRHL3通过增强SIRT1介导的SOX2稳定促进肺鳞状细胞癌远处多器官转移
Zhanzhan Li,Baishuang Yang,Meihua Long et al.
Zhanzhan Li et al.
Aberrant expression of grainyhead-like transcription factor 3 (GRHL3) has been extensively reported in the development and progression of several squamous cell carcinomas, such as cutaneous, head and neck, and esophageal squamous cell carci...
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome [0.03%]
计算病理学在临床结直肠癌队列中的应用识别出预测结果的免疫和内皮细胞空间模式
Nicholas Trahearn,Chirine Sakr,Abhirup Banerjee et al.
Nicholas Trahearn et al.
Colorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our underst...
Loss of Mist1 alters the characteristics of Paneth cells and impacts the function of intestinal stem cells in physiological conditions and after radiation injury [0.03%]
Mist1缺失改变潘氏细胞的特征并在生理状态下和放射损伤后影响肠道干细胞的功能
Yujun Huang,Siyu Tu,Zhenni Xu et al.
Yujun Huang et al.
Intestinal stem cells (ISCs) and Paneth cells (PCs) reside at the bottom of the crypts of Lieberkühn in the small intestine. Recent studies have shown that the transcription factor Mist1, also named BHLHA15, plays an important role in the ...