Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response [0.03%]
血小板C3G通过调节免疫反应保护肝脏免受纤维化，同时促进肿瘤生长
Cristina Baquero,Minerva Iniesta-González,Nerea Palao et al.
Cristina Baquero et al.
Primary liver cancer usually occurs in the context of chronic liver disease (CLD), in association with fibrosis. Platelets have emerged as important regulators of CLD and liver cancer, although their precise function and mechanism of action...
PI3 expression predicts recurrence after chemotherapy with DNA-damaging drugs in gastric cancer [0.03%]
PI3的表达预测了胃癌在DNA破坏药物的化疗后复发的可能性
Kenji Harada,Naoya Sakamoto,Takumi Kitaoka et al.
Kenji Harada et al.
Despite recent advances in gastric cancer therapy, chemotherapy resistance and lack of methods for selecting combination regimens remain major problems. Organoids, which provide a culture system that more closely resembles tumor cell organi...
Spatial profiling of ANO7 in prostate tissue: links to AR-signalling-associated lipid metabolism and inflammation [0.03%]
AN07在前列腺组织中的空间分布特征：与AR信号相关的脂质代谢和炎症的关联
Olli Metsälä,Gudrun Wahlström,Neha Goel et al.
Olli Metsälä et al.
Prostate cancer (PrCa) is highly prevalent in the Western world. Currently, however, there are many unmet needs in PrCa care, for example in distinguishing between clinically significant and indolent cases in early phases of the disease. AN...
A deep-learning model for predicting tyrosine kinase inhibitor response from histology in gastrointestinal stromal tumor [0.03%]
用于预测胃肠间质瘤中酪氨酸激酶抑制剂反应的深度学习模型
Xue Kong,Jun Shi,Dongdong Sun et al.
Xue Kong et al.
Over 90% of gastrointestinal stromal tumors (GISTs) harbor mutations in KIT or PDGFRA that can predict response to tyrosine kinase inhibitor (TKI) therapies, as recommended by NCCN (National Comprehensive Cancer Network) guidelines. However...
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom-up approach [0.03%]
自下而上重新定义胰腺导管腺癌的表型异质性
Marc Hilmi,Flore Delecourt,Jérôme Raffenne et al.
Marc Hilmi et al.
Pancreatic ductal adenocarcinoma (PDAC) tumor interpatient heterogeneity has been well described with two major prognostic subtypes (classical and basal-like). An important intrapatient heterogeneity has been reported but has not yet been s...
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms [0.03%]
揭秘致癌KRAS、形态变化和胰腺黏液性囊性神经内分泌肿瘤突变复杂性的关系
Schulte,Annika Beck,Ralf Marienfeld et al.
Schulte et al.
Pancreatic ductal adenocarcinoma (PDAC) often arises from preexisting cystic lesions such as intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). This study investigated the molecular heterogeneity and mutati...
Clonal dynamics of chronic myelomonocytic leukemia progression: paired-sample comparison [0.03%]
慢性粒单细胞白血病进展的克隆动力学：配对样本比较
Hsiao-Wen Kao,Ming-Chung Kuo,Che-Wei Ou et al.
Hsiao-Wen Kao et al.
This study investigated the clonal evolution of chronic myelomonocytic leukemia (CMML) progression to secondary acute myeloid leukemia (sAML) by next-generation sequencing and pyrosequencing for variant allele frequency (VAF) of gene mutati...
Downregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells [0.03%]
AATK下调通过促进吉非替尼耐药肺癌细胞中的早期内体循环来增强铁死亡敏感性
Wei-Chang Lee,Sin-Hua Moi,Sheau-Fang Yang et al.
Wei-Chang Lee et al.
Ferroptosis has been characterised by disruption of the cell membrane through iron-related lipid peroxidation. However, regulation of iron homeostasis in lung cancer cells that are resistant to epidermal growth factor receptor tyrosine kina...
SMARCB1-deficient malignant melanocytic uveal tumours: a new neural crest-derived tumour entity with SMARCB1-related germline predisposition [0.03%]
SMARCB1缺陷性恶性黑色素上皮肿瘤：一种具有SMARCB1相关遗传易感性的新神经嵴来源的肿瘤实体
Joanna Cyrta,Julien Masliah-Planchon,Owen Hoare et al.
Joanna Cyrta et al.
Rhabdoid tumours (RT) are an aggressive malignancy affecting
Alternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations [0.03%]
外周神经鞘肿瘤的替代驱动途径-包括DICER1和/或KRAS改变
Hsin-Yi Chang,Carla Saoud,Dianne Torrence et al.
Hsin-Yi Chang et al.
DICER1-associated sarcoma is an emerging entity, defined by either somatic or germline dicer 1, ribonuclease III (DICER1) mutations and sharing characteristic morphologic features irrespective of the site of origin. In addition to the DICER...