MS4A4A-positive tumor-associated macrophages associate with poor prognosis and T-cell exhaustion in patients with urothelial carcinoma of the bladder [0.03%]
MS4A4A阳性肿瘤相关巨噬细胞与膀胱尿路上皮癌患者预后不良和T细胞衰竭相关
Tenghao Yang,Xi Sun,Jiaming Chen et al.
Tenghao Yang et al.
Tumor-associated macrophages (TAMs) have multiple potent functions in cancer representing important therapeutic targets. MS4A4A is a functional TAM marker with controversial implications for prognosis. This study aimed to evaluate the assoc...
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions [0.03%]
基于归档的FFPE样本对原发性神经母细胞瘤微环境进行空间转录组学探索，揭示了新的旁分泌相互作用
Joachim T Siaw,Peter Merseburger,Marcus Borenäs et al.
Joachim T Siaw et al.
High-risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single-cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about loca...
Revisionist history uncovers a simplified molecular-based classification of differentiated thyroid cancer [0.03%]
修正历史发现基于分子的分化型甲状腺癌分类被简化
Sylvia L Asa,Zubair Baloch,Chan Kwon Jung et al.
Sylvia L Asa et al.
The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and su...
Increased expression of the PIEZO2 mechanoreceptor in fibroblasts and endothelial cells within the lymphatic and vascular vessels of keloids [0.03%]
成纤维细胞和内皮细胞中的PIEZO2机械受体在瘢痕组织中表达量增加
Shinsuke Akita,Sanae Ikehara,Masahiro Kiuchi et al.
Shinsuke Akita et al.
Keloids are scars that grow abnormally due to excessive extracellular matrix production by fibroblasts and increased angiogenesis. Chronic tension is implicated in their growth, but the exact pathology remains unclear. This study investigat...
Partial-EMT cell state correlates with single cell pattern of invasion in head and neck SCC keratinocytes [0.03%]
部分上皮间质转化状态与头颈部鳞癌角化细胞单细胞侵袭模式相关性研究
Pyung Hun Park,Lauren E Israel,Michael H Alexander et al.
Pyung Hun Park et al.
The presence of a single metastatic lesion significantly decreases overall survival in patients with head and neck squamous cell carcinoma (HNSCC), and invasion of malignant keratinocytes is one of the initial steps required for HNSCC metas...
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms† [0.03%]
胰腺管内乳头状黏液性肿瘤进展中肿瘤微环境调控的重要作用
Antonio Pea,Claudio Luchini
Antonio Pea
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have attracted substantial attention since they represent the most prevalent macroscopic precursor of pancreatic cancer. Most lesions show an epithelium with low-grade dysplas...
New insights into the genetic progression of cancer through longitudinal analysis of oral lesions [0.03%]
纵向分析口腔病变揭示癌症遗传演变的新见解
Leon J Wils,Jos B Poell,Arjen Brink et al.
Leon J Wils et al.
Genetic progression models of cancer continue to determine the roadmap of carcinogenesis, although the sequence of genetic events is inferred rather than empirically determined through longitudinal analyses. Here, we present a unique longit...
Maternal-foetal immune rejection: parallels between placental CHI and allograft rejection† [0.03%]
母胎免疫排斥：胎盘CHI与同种异体移植排斥的类比
Panicos Shangaris,María Teresa Martín Monreal
Panicos Shangaris
Chronic histiocytic intervillositis (CHI) is a rare placental inflammatory lesion increasingly viewed through maternal-foetal immune rejection. In this invited commentary, we discuss how a recent study bolsters the paradigm that CHI represe...
LncRNA GAS5 ameliorates intestinal barrier injury by targeting the miR-223-3p/FBXW7 axis and inactivating NF-κB signaling in vitro and in vivo [0.03%]
长链非编码RNA GAS5通过靶向miR-223-3p/FBXW7轴并使NF-κB失活来改善体内外肠屏障损伤
Zhen Wang,Jin Yuan,Xuemei Qin et al.
Zhen Wang et al.
Sepsis is a potentially lethal syndrome that leads to multiple organ dysfunction. LncRNA GAS5 is closely related to sepsis; however, its detailed functions and mechanism in sepsis-triggered intestinal barrier dysfunction are unclear. In thi...
Spatial transcriptomics identifies SPARC as a prognostic marker in interstitial lung diseases [0.03%]
空间转录组学鉴定出SPARC是间质性肺病的预后标志物
Takayuki Niitsu,Toshiaki Kataoka,Kiyoharu Fukushima et al.
Takayuki Niitsu et al.
Interstitial lung diseases (ILDs) encompass a diverse group of pulmonary disorders, with progressive fibrosis leading to poor prognosis. Here we aimed to identify key molecules involved in progressive fibrosis across various ILDs, using spa...