Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis [0.03%]
肾小管周围毛细血管密度和微循环的改变对肾纤维化及肾小管损伤进展的贡献
Zhengrong Ren,Fang Shao,Shuli Chen et al.
Zhengrong Ren et al.
Peritubular capillary (PTC) rarefaction is a common pathological feature of chronic kidney disease (CKD). The critical function of PTCs in maintaining blood supply for tubular epithelial cells renders PTCs a promising therapeutic target. Ho...
Jack C Henry,Angus J M Cameron
Jack C Henry
In solid tumours, malignant cells develop relationships with nonmalignant stromal cells to support tumour growth, tissue structure, and nutrient supply. In a recent issue of this journal, Zheng and Guo catalogue the cellular landscape in ch...
Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway [0.03%]
血小板生成素-1通过抑制NF-κB通路绑定整联蛋白β3来抑制血管钙化
Fang Liu,Qingchun Liang,Li Li et al.
Fang Liu et al.
Vascular calcification is an important risk factor related to all-cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). Vascular extracellular matrix (ECM) proteins have been demonstrated to regulate vascul...
Interleukin-11 expressed in the polyp-enriched fibroblast subset is a potential therapeutic target in Peutz-Jeghers syndrome [0.03%]
在息肉富集的成纤维细胞子集中表达的白介素-11是Peutz-Jeghers综合征的一个潜在治疗靶点
Eva Domènech-Moreno,Wei-Wen Lim,Melissa G Montrose et al.
Eva Domènech-Moreno et al.
Peutz-Jeghers syndrome (PJS) is associated with early-onset gastrointestinal polyposis caused by hereditary inactivating pathogenic variants in the tumor suppressor gene STK11 (LKB1). Due to lack of prophylactic therapies, management of PJS...
Emil Chteinberg,Julia Kolarova,Julia Vogt et al.
Emil Chteinberg et al.
Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial-, neuroendocrine-, and lymphoid-associated genes. Here, we focused on B-cell differentiation, which is characterised by the coexpression of PAX5 and TdT...
Nicola S Meagher,Martin Köbel,Anthony N Karnezis et al.
Nicola S Meagher et al.
Mucinous ovarian carcinoma (MOC) is a rare histotype of epithelial ovarian cancer. Its origins are obscure: while many mucinous tumours in the ovary are metastases from the gastrointestinal tract, MOC can occur as an ovarian primary; howeve...
Afadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage [0.03%]
AFADIN的丢失通过破坏E-钙粘素到F肌动蛋白的连接促进乳腺癌转移
Max Ak Rätze,Lotte Nfl Enserink,Noboru Ishiyama et al.
Max Ak Rätze et al.
Afadin is a multimodal scaffolding protein with essential functions in cell-cell adhesion. Although its loss of expression has been linked to breast cancer invasion and metastasis, the underlying mechanisms driving tumour progression upon m...
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia [0.03%]
多组学空间图谱显示恶性脑肿瘤中缺失的1(DMBT1)糖蛋白在结肠不典型增生中丢失
Emily H Green,Subhag R Kotrannavar,Megan E Rutherford et al.
Emily H Green et al.
Colorectal cancer (CRC) is responsible for over 900,000 annual deaths worldwide. Emerging evidence supports pro-carcinogenic bacteria in the colonic microbiome are at least promotional in CRC development and may be causal. We previously sho...
Should we worry about high-grade pancreatic neuroendocrine tumor progression and alkylating agents?† [0.03%]
我们应该担心高分级胰腺神经内分泌肿瘤的进展和烷化剂吗？
Wenzel M Hackeng,Koen Ma Dreijerink,Lodewijk Aa Brosens
Wenzel M Hackeng
Predicting metachronous metastases in localized pancreatic neuroendocrine tumors (PanNETs) and improving survival of patients with advanced disease are some of the most important goals in PanNET research. Both are addressed by a study publi...
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms [0.03%]
与人导管内乳头状黏液瘤进展相关的肿瘤免疫微环境变化
Kevin T Jamouss,Alexander Ioannis Damanakis,Abigail C Cornwell et al.
Kevin T Jamouss et al.
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late-stage diagnoses. To improve patient outcomes, early intervention in precursor lesions such as intraductal papillary mucinous neoplasm (IPMN) is crucial. Howev...