Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma† [0.03%]
异常的TERT表达：慢性炎症与肝细胞癌之间的联系
Rui Dong,Gregoire Najjar,Cagatay Günes et al.
Rui Dong et al.
Telomerase reverse transcriptase (TERT), the catalytic enzyme component of telomerase, plays multiple roles in cellular biology. Its canonical function is primarily associated with telomere maintenance and genomic stability. In addition, se...
Eloise Clarkson,Annabelle Lewis
Eloise Clarkson
Colorectal cancer (CRC) is the third most common form of cancer globally, and arises from the hyperproliferation of epithelial cells in the intestine. The architecture and maintenance of these cells is governed by two major signalling pathw...
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination [0.03%]
组蛋白脱乙酰酶6抑制通过促进MAP1LC3B泛素化来增强自噬从而缓解病理性心室肥大
Jiayu Yao,Xiaoou Sun,Yousheng Chen et al.
Jiayu Yao et al.
Cardiac hypertrophy is an adaptive response of the heart to pathological stimuli that may lead to cardiac dysfunction and heart failure. Histone deacetylase 6 (HDAC6) participates in the progression of multiple cardiovascular diseases, incl...
Utilizing aptamers in targeted protein degradation strategies for disease therapy [0.03%]
利用适配子进行靶向蛋白质降解的疾病治疗策略
Lin Li,Songbo Xie,Jun Zhou et al.
Lin Li et al.
Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy, offering the potential to reduce disease-causing proteins that have traditionally been challenging to target using conventional small molecules. Despite sig...
A Tc1- and Th1-T-lymphocyte-rich tumor microenvironment is a hallmark of MSI colorectal cancer [0.03%]
错义突变结直肠癌肿瘤微环境富含Tc1和Th1淋巴细胞
Zhihao Huang,Tim Mandelkow,Nicolaus F Debatin et al.
Zhihao Huang et al.
Microsatellite instability is a strong predictor of response to immune checkpoint therapy and patient outcome in colorectal cancer. Although enrichment of distinct T-cell subpopulations has been determined to impact the response to immune c...
Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis [0.03%]
肾移植抗体介导性排斥反应与慢性绒毛间质细胞炎的病理及分子特征支持其具有共同发病机制
Léonie Albersammer,Juliette Leon,Jelena Martinovic et al.
Léonie Albersammer et al.
Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a 'maternal-fo...
MicroRNA-371-373 cluster and methylome analysis suggests that a subset of 'somatic-type' malignancies arising in germ cell tumors may originate in yolk sac tumor components [0.03%]
微小核糖核酸-371-373聚类和甲基定相分析表明，在生殖细胞肿瘤中出现的一组“体细胞性”恶性肿瘤可能起源于卵黄囊肿瘤成分
João Lobo,Nuno Tiago Tavares,Diana Fonseca et al.
João Lobo et al.
Somatic-type malignancies (SMs) arising in germ cell tumors (GCTs) are aggressive neoplasms resistant to systemic treatment. Most are diagnosed in metastatic sites after chemotherapy; however, they have also been well-documented in primary ...
Multi-omics analyses reveal distinct molecular characteristics and transformation mechanisms of stage I-III micropapillary lung adenocarcinoma [0.03%]
多组学分析揭示了I-III期微乳头肺癌腺癌的不同分子特征和转化机制
Yang Qu,Xiaoli Feng,Hanlin Chen et al.
Yang Qu et al.
The micropapillary (MIP) pattern is a high-grade histological subtype of lung adenocarcinoma (LUAD) with poor prognosis. In this study, surgically resected tumor samples from 101 patients with stage I-III MIP-LUAD (MIP ≥30%) were microdiss...
Phosphodiesterase 5 inactivation in vascular smooth muscle cells aggravates aortic aneurysm and dissection [0.03%]
血管平滑肌细胞中的磷酸二酯酶5失活加重了主动脉瘤和剥离
Yuyao Feng,Yunfei Xue,Xiaohang Feng et al.
Yuyao Feng et al.
Aortic aneurysm and dissection (AAD) are vascular disorders with high mortality. Previous evidence has suggested an elevated risk of AAD associated with the use of phosphodiesterase 5A (PDE5A) inhibitors. PDE5A, a cGMP-hydrolyzing enzyme, i...
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high-risk patients† [0.03%]
富含管腔（ER+）肿瘤和年轻围绝经前患者的乳腺癌PDX集合，以识别高危患者的新治疗策略†
Paola Defilippi,Francesca Nigrelli,Pietro Arina et al.
Paola Defilippi et al.
Breast cancer includes a group of neoplasms originating from mammary gland epithelial cells caused by a variety of genetic alterations, with different responses to treatments and outcomes. In clinical practice, estrogen receptor (ER), proge...