NSD1 mutation status determines metabolic inhibitor sensitivity in head and neck squamous cell carcinomas by regulating mitochondrial respiration [0.03%]
NSD1突变状态通过调节线粒体呼吸决定头颈鳞癌中代谢抑制剂敏感性
Shouyi Tang,Qing Wang,Zhen Wang et al.
Shouyi Tang et al.
Head and neck squamous cell carcinomas (HNSCCs) are the most common malignant tumors in the head and neck region, characterized by a high recurrence rate and early metastasis. Despite advances in treatment, patient outcomes and prognosis re...
Cystathionine gamma-lyase-mediated hypoxia inducible factor 1-alpha expression drives clear cell ovarian cancer progression [0.03%]
半胱氨酸γ裂解酶介导的低氧诱导因子表达驱动卵巢透明细胞癌进展
Amal M El-Naggar,Yuqin Li,Busra Turgu et al.
Amal M El-Naggar et al.
Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%-11% of ovarian cancers in North America. Late-stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, ...
The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma [0.03%]
TBXT rs2305089基因多态性与良性软骨内细胞瘤及未分化脊索瘤的关系
Inga Usher,Paul O&#x;Donnell,Lorena Ligammari et al.
Inga Usher et al.
The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNC...
Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes [0.03%]
对KRAS野生型胰腺导管腺癌的临床病理和分子特征进行表征，发现具有RAS通路基因致癌突变和融合的前体病变
Kazuhiro Toriyama,Katsuhiro Masago,Noriko Shibata et al.
Kazuhiro Toriyama et al.
Pancreatic ductal adenocarcinomas (PDACs) with wild-type KRAS constitute a small fraction of PDACs, and these tumors were recently shown to harbor frequent actionable oncogenic mutations and fusions. However, the clinicopathological feature...
Comprehensive functional splicing analysis of non-canonical CNGB3 variants using in vitro minigene splice assays [0.03%]
应用体外拼接子基因分析法对非经典的CNGB3变异进行综合功能拼接分析
Katharina Rawnsley,Nicole Weisschuh,Susanne Kohl et al.
Katharina Rawnsley et al.
Variants in the CNGB3 gene, encoding the B3-subunit of the cone photoreceptor cyclic nucleotide gated channel, are a major cause of autosomal recessive achromatopsia, a rare inherited retinal disease. The mutation spectrum of achromatopsia-...
In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas [0.03%]
SOX10插入突变在胃肠道施万细胞瘤中的富集及其转录组特征分析
Pei-Hang Lee,Shih-Chiang Huang,Jen-Chieh Lee et al.
Pei-Hang Lee et al.
Gastrointestinal schwannomas are molecularly and histologically distinct from their non-gastrointestinal counterparts, lacking NF2 alterations, although the primary drivers of these tumors are barely understood. A recent study has identifie...
Comparative transcriptomics of salivary basal cell adenoma and adenocarcinoma sustain linear neoplastic evolution and intertumor heterogeneity: classification and biological implications [0.03%]
涎腺黏液基底细胞腺瘤和腺癌的转录组学比较：肿瘤间异质性、线性转化及临床病理意义
Yoshitsugu Mitani,Haneen Al-Maghrabi,Tatiana V Karpinets et al.
Yoshitsugu Mitani et al.
It remains uncertain whether basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland represent two distinct neoplasms or temporal stages of a single entity. The issue is central to reconciling their shared phenot...
Nicotine-driven enhancement of tumor malignancy in triple-negative breast cancer via additive regulation of CHRNA9 and IGF1R [0.03%]
尼古丁通过CHRNA9和IGF1R的叠加调节在三阴性乳腺癌中增强肿瘤恶性程度
Yung-Che Kuo,Chi-Long Chen,Kha-Liang Lee et al.
Yung-Che Kuo et al.
Cigarette smoking is a significant risk factor for cancer development with complex mechanisms. This study aims to investigate the impact of nicotine exposure on the regulation of stemness- and metastasis-related properties via cholinergic r...
Activated immune infiltrates expand opportunities for targeted therapy in p53-abnormal endometrial carcinoma [0.03%]
活化的免疫浸润为p53异常子宫内膜癌的靶向治疗提供了新思路
Spencer D Martin,Shelby Thornton,Christine Chow et al.
Spencer D Martin et al.
Tumor protein p53 mutated/abnormal (p53abn) endometrial carcinomas account for over 50% of deaths but comprise only 15% of all endometrial carcinomas. Most patients show limited response to standard-of-care chemotherapy with or without radi...