Involvement of KEAP1/NRF2 pathway in non-BRAF mutated squamous cell carcinoma of the thyroid [0.03%]
KEAP1/NRF2信号通路在非BRAF突变甲状腺鳞状细胞癌中的作用
Elin Schoultz,Jakob Dahlberg,Lisa M Nilsson et al.
Elin Schoultz et al.
Squamous cell carcinoma (SCC) of the thyroid is a rare tumor that is classified as an anaplastic thyroid cancer (ATC) due to its similar unresponsiveness to chemoradiotherapy and an outstandingly poor prognosis. Due to its rarity, current k...
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors [0.03%]
胰腺和肝脏粘液性囊性肿瘤与卵巢粘液性肿瘤具有相似的DNA甲基化谱特征
Zoe Leoni,Teodor G Calina,Tobias Janik et al.
Zoe Leoni et al.
The origin of mucinous cystic neoplasms (MCNs) remains a major challenge in hepato-pancreato-biliary pathology. These cystic tumors are defined by their mucinous epithelium and ovarian-like stroma, with an estimated 10% risk of progression ...
Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer [0.03%]
IDH1和IDH2基因突变导致结直肠癌高甲基化表型的机制分析
Joseph C Ward,Melissa Morgan,James Wood et al.
Joseph C Ward et al.
The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have ...
Circulating metabolomics reveals guanosine monophosphate synthetase (GMPS) as a novel therapeutic target in lung adenocarcinoma [0.03%]
循环代谢组学揭示了鸟苷酸合成酶(GMPS)是肺腺癌的潜在治疗靶点
Mengjie Yu,Dou Yang,Danxia Zhu et al.
Mengjie Yu et al.
Metabolic reprogramming is pivotal in the initiation and progression of lung adenocarcinoma (LUAD). However, a substantial gap remains in the understanding of the primary drivers of metabolic reprogramming and alterations in early-stage LUA...
Genetic deletion of histone deacetylase 6 prevents peritoneal fibrosis via suppression of heat shock protein 90 deacetylation [0.03%]
遗传删除组蛋白去乙酰化酶6通过抑制热休克蛋白90脱乙酰基来预防腹膜纤维化
Yingfeng Shi,Jinqing Li,Qin Zhong et al.
Yingfeng Shi et al.
Peritoneal fibrosis (PF) is a serious complication contributing to ultrafiltration failure in patients undergoing peritoneal dialysis that currently lacks effective treatment strategies. Our recent studies highlighted the key role of histon...
Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential [0.03%]
改进的具有转移潜力的单病灶小鼠原发性肺癌模型的建立及鉴定
Ana-Rita Pedrosa,Alejandro Castillo-Kauil,Yuliia Kravchuk et al.
Ana-Rita Pedrosa et al.
Lung cancer is the leading cause of cancer-related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein-injected tumour cell lines or genetically modified mice. The current...
Soft tissue sarcoma with MN1 gene fusions: a report of three cases with aggressive clinical behavior [0.03%]
MN1基因重排的软组织肉瘤：3例具有侵袭性临床行为的病例报道
Carla Saoud,Josephine K Dermawan,Narasimhan P Agaram et al.
Carla Saoud et al.
Canonical MN1 fusions with either BEND2 or CXXC5 gene partners represent the molecular hallmark of astroblastoma, a stand-alone group among central nervous system (CNS) high-grade neuroepithelial tumors based on their distinct methylation p...
Post-COVID-19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies [0.03%]
新冠肺炎后遗症的临床分型、病理生理机制、组织病理改变及管理策略
Larissa E Vlaming-van Eijk,Guolu Tang,Arno R Bourgonje et al.
Larissa E Vlaming-van Eijk et al.
Post-COVID-19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID-19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinica...
Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization [0.03%]
黏液性囊性肿瘤和单纯黏液性囊肿是两种不同的胰腺癌前体：临床病理、基因组和转录组特征分析
Antonio Pea,Michele Bevere,Anastasios Gkountakos et al.
Antonio Pea et al.
Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian-type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, ...