shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth [0.03%]
人胶质瘤干细胞中由shRNA介导的PPARα敲低可降低其在体外的增殖并抑制原位异种移植物肿瘤生长
Harry R Haynes,Helen L Scott,Clare L Killick-Cole et al.
Harry R Haynes et al.
The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcri...
Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions [0.03%]
卵巢癌前病变的基因组景观和进化轨迹
Ren-Chin Wu,Pei Wang,Shiou-Fu Lin et al.
Ren-Chin Wu et al.
The clonal relationship between ovarian high-grade serous carcinoma (HGSC) and its presumed precursor lesion, serous tubal intraepithelial carcinoma (STIC), has been reported. However, when analyzing patients with concurrent ovarian carcino...
More expression, less function: cleaved dynamin in glomerular kidney disease [0.03%]
更表达，少功能：肾小球肾脏病中的分裂动力蛋白
Mehmet M Altintas,Jochen Reiser
Mehmet M Altintas
The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes (FPs). Destruction of dynamin, for example by ca...
Silvio R Podmirseg,Jonathan Vosper,Ludger Hengst
Silvio R Podmirseg
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non-small cell lung carcinoma (NSCLC) subtype accounting for the majority of cases. Therefore, an urgent need exists for a more detailed dissection ...
Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone [0.03%]
MAPK信号通路的激活突变定义了骨纤维结构不良
Daniel Baumhoer,Michal Kovac,Jan Sperveslage et al.
Daniel Baumhoer et al.
Non-ossifying fibroma (NOF), which occasionally results in pathologic fracture, is considered the most common benign and self-limiting lesion of the growing skeleton. By DNA sequencing we have identified hotspot KRAS, FGFR1 and NF1 mutation...
Multicenter Study
The Journal of pathology. 2019 May;248(1):116-122. DOI:10.1002/path.5216 2019
Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis [0.03%]
成纤维细胞特异性的整合素αv调控类型17和类型2驱动的炎症及纤维化
Joshua C Sciurba,Richard L Gieseck,Nikhil Jiwrajka et al.
Joshua C Sciurba et al.
Fibroproliferative diseases affect a significant proportion of the world's population. Despite this, core mechanisms driving organ fibrosis of diverse etiologies remain ill defined. Recent studies suggest that integrin-alpha V serves as a m...
Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia [0.03%]
干扰素-γ直接诱导胃上皮细胞死亡并促进肠上皮化生的发展
Luciana H Osaki,Kevin A Bockerstett,Chun F Wong et al.
Luciana H Osaki et al.
Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern ma...
Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities [0.03%]
黑色素瘤亚型：基因组谱型、预后分子标志物及治疗可能性
Roy Rabbie,Peter Ferguson,Christian Molina-Aguilar et al.
Roy Rabbie et al.
Melanoma is characterised by its ability to metastasise at early stages of tumour development. Current clinico-pathologic staging based on the American Joint Committee on Cancer criteria is used to guide surveillance and management in early...
Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis [0.03%]
动脉粥样血栓形成过程中巨噬细胞、肥大细胞、嗜酸性粒细胞和中性粒细胞产生的胞外诱捕网呈时间依赖性生成
Kartika R Pertiwi,Onno J de Boer,Claire Mackaaij et al.
Kartika R Pertiwi et al.
Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory cell types in coronary atherosclerotic plaque or thrombus also release extracell...