TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG [0.03%]
TBX3通过诱导上皮间质转化和直接上调SLUG来促进乳腺癌前侵袭性细胞的进展
Milica Krstic,Bart Kolendowski,Matthew J Cecchini et al.
Milica Krstic et al.
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecula...
Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma [0.03%]
肝细胞癌和肝内胆管癌的基因组特征相似性研究
Nancy M Joseph,Christos G Tsokos,Sarah E Umetsu et al.
Nancy M Joseph et al.
Combined hepatocellular-cholangiocarcinomas (CHC) are mixed tumours with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) components. CHC prognosis is similar to intrahepatic CC (ICC) and worse than HCC; staging and treatment...
Comparative Study
The Journal of pathology. 2019 Jun;248(2):164-178. DOI:10.1002/path.5243 2019
Takuto Yoshioka,Akihisa Fukuda,Osamu Araki et al.
Takuto Yoshioka et al.
In the mammalian stomach, the isthmus has been considered as a stem cell zone. However, various locations and proliferative activities of gastric stem cells have been reported. We focused here on the stem cell marker Bmi1, a polycomb group ...
Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury [0.03%]
第2组固有淋巴样细胞在急性肾损伤中的治疗潜力
Guy J M Cameron,Simon H Jiang,Svenja Loering et al.
Guy J M Cameron et al.
Acute kidney injury (AKI) remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an AKI are at increased risk of developing chronic kidney disease and end stage renal failu...
The innate immune architecture of lung tumors and its implication in disease progression [0.03%]
肺肿瘤的先天免疫架构及其在疾病进展中的作用
Simon Milette,Pierre O Fiset,Logan A Walsh et al.
Simon Milette et al.
Lung malignancies are the leading cause of cancer-related mortality. By virtue of its unique physiological function, the lung microenvironment is highly dynamic and constantly subjected to mechanical, chemical and pathogenic stimuli. Thus, ...
Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells [0.03%]
丙型肝炎病毒感染诱导人胎儿肝脏干细胞内质网应激及细胞凋亡
Xuan Guo,Wei-Li Liu,Dong Yang et al.
Xuan Guo et al.
The cellular mechanisms by which hepatitis C virus (HCV) replication might mediate cytopathic effects are controversial and not entirely clear. In this study, we found that blood-borne HCV (bbHCV) infection could lead to endoplasmic reticul...
Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma [0.03%]
EB病毒致癌基因LMP1通过调控S1PR2促进弥漫大B细胞淋巴瘤侵袭性的分子机制研究
Martina Vockerodt,Katerina Vrzalikova,Maha Ibrahim et al.
Martina Vockerodt et al.
The Epstein-Barr virus (EBV) is found almost exclusively in the activated B-cell (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), yet its contribution to this tumour remains poorly understood. We have focused on the EBV-encoded laten...
NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling [0.03%]
NSD2环状RNA通过靶向miR-199b-5p介导的DDR1和JAG1信号促进结直肠癌转移
Liang-Yan Chen,Zheng Zhi,Lian Wang et al.
Liang-Yan Chen et al.
Liver metastasis is the main cause of death in patients with colorectal cancer (CRC). Here, we searched for CRC metastasis-associated circular RNA in a mouse model of liver metastasis of CRC by using RNA (transcriptome)-sequencing. We ident...
Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms [0.03%]
整合微生物学、分子病理学和流行病学：探索微生物驱动性肿瘤发病机制的新范式
Tsuyoshi Hamada,Jonathan A Nowak,Danny A Milner Jr et al.
Tsuyoshi Hamada et al.
Molecular pathological epidemiology (MPE) is an integrative transdisciplinary field that addresses heterogeneous effects of exogenous and endogenous factors (collectively termed 'exposures'), including microorganisms, on disease occurrence ...