Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1 [0.03%]
长链非编码RNA影响肺动脉高压转录组：PAXIP1-AS1的作用
Katharina Jandl,Helene Thekkekara Puthenparampil,Leigh M Marsh et al.
Katharina Jandl et al.
In idiopathic pulmonary arterial hypertension (IPAH), global transcriptional changes induce a smooth muscle cell phenotype characterised by excessive proliferation, migration, and apoptosis resistance. Long non-coding RNAs (lncRNAs) are key...
Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions [0.03%]
单细胞测序揭示了胰腺癌前病变中的遗传异质性
Yuko Kuboki,Catherine G Fischer,Violeta Beleva Guthrie et al.
Yuko Kuboki et al.
Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer; however, little is known about genetic heterogeneity in these lesions. The objective of this study was to characterize genetic heterogeneity in IPMNs at t...
Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions [0.03%]
雌激素受体α阳性乳腺癌管腔内原位移植瘤动物模型再现了人类病变的组织病理特征和转移潜能
Maryse Fiche,Valentina Scabia,Patrick Aouad et al.
Maryse Fiche et al.
Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER-positive ...
Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2 [0.03%]
炎症通过下调BMPR2诱导血管内皮细胞向间充质细胞转化并促进血管钙化
Gonzalo Sánchez-Duffhues,Amaya García de Vinuesa,Vera van de Pol et al.
Gonzalo Sánchez-Duffhues et al.
Endothelial-to-mesenchymal transition (EndMT) has been unveiled as a common cause for a multitude of human pathologies, including cancer and cardiovascular disease. Vascular calcification is a risk factor for ischemic vascular disorders and...
Fc-binding proteins enhance autoantibody-induced BP180 depletion in pemphigoid [0.03%]
Fc结合蛋白增强自身抗体诱导的天疱疮BP180耗竭
Hiroaki Iwata,Mayumi Kamaguchi,Hideyuki Ujiie et al.
Hiroaki Iwata et al.
Immunoglobulins (Igs) consist of two antigen-binding regions (Fab) and one constant region (Fc). Protein A and protein G are bacterial proteins used for the purification of IgG by virtue of their high affinities for the Fc fragment. Rheumat...
Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes [0.03%]
阿霉素诱导的心脏毒性与IFNγ介导的心肌细胞代谢重编程有关
Chen Ni,Pan Ma,Ruirui Wang et al.
Chen Ni et al.
Immune responses contribute to a large extent to heart diseases. However, it is still not clear how the key inflammatory mediator interferon-γ (IFNγ) plays a role in doxorubicin (DOX)-induced cardiomyopathy. We report here that DOX-induce...
Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer [0.03%]
DOCK4作为乳腺癌骨转移风险生物标志物的鉴定与验证
Jules A Westbrook,Steven L Wood,David A Cairns et al.
Jules A Westbrook et al.
Skeletal metastasis occurs in around 75% of advanced breast cancers, with the disease incurable once cancer cells disseminate to bone, but there remains an unmet need for biomarkers to identify patients at high risk of bone recurrence. This...
UCP2-dependent improvement of mitochondrial dynamics protects against acute kidney injury [0.03%]
UCP2依赖的线粒体动态改善对急性肾损伤的保护作用
Nan Qin,Ting Cai,Qingqing Ke et al.
Nan Qin et al.
Acute kidney injury (AKI) is a public health concern, with high morbidity and mortality rates in hospitalized patients and because survivors have an increased risk of progression to chronic kidney disease. Mitochondrial damage is the critic...
Recent advances in breast cancer research impacting clinical diagnostic practice [0.03%]
近期乳腺癌研究的新进展及其对临床诊断实践的影响
Amy E McCart Reed,Priyakshi Kalita-De Croft,Jamie R Kutasovic et al.
Amy E McCart Reed et al.
During the last decade, the genomics revolution has driven critical advances in molecular oncology and pathology, and a deeper appreciation of heterogeneity that is beginning to reshape our thinking around diagnostic classification. Recent ...
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration [0.03%]
TYRO蛋白酪氨酸磷酸酶Shp-2通过促进杯状细胞功能和隐窝再生来赋予结肠炎抵抗能力
Jessica Gagné-Sansfacon,Ariane Langlois,Marie-Josée Langlois et al.
Jessica Gagné-Sansfacon et al.
The Src homology-2 domain-containing tyrosine phosphatase 2 (SHP-2) regulates many cellular processes, including proliferation, differentiation and survival. Polymorphisms in the gene encoding SHP-2 are associated with an increased suscepti...