MAPK pathway-activating mutations drive giant cell lesions of the jaws and non-ossifying fibromas of bone [0.03%]
激活MAPK通路的突变驱动颌骨巨大细胞病变及骨非成骨性纤维瘤的发展
Carolina C Gomes,Ricardo S Gomez
Carolina C Gomes
Anna C Wilkins,Emmanuel C Patin,Kevin J Harrington et al.
Anna C Wilkins et al.
Historically, our understanding of the cytotoxicity of radiation has centred on tumour cell-autonomous mechanisms of cell death. Here, tumour cell death occurs when a threshold number of radiation-induced non-reparable double-stranded DNA b...
Molecular profiling in muscle-invasive bladder cancer: more than the sum of its parts [0.03%]
肌层浸润性膀胱癌的分子分型：整体大于部分之和
Gottfrid Sjödahl,Chelsea L Jackson,John Ms Bartlett et al.
Gottfrid Sjödahl et al.
Bladder cancers are biologically and clinically heterogeneous. Recent large-scale transcriptomic profiling studies focusing on life-threatening muscle-invasive cases have demonstrated a small number of molecularly distinct clusters that lar...
High-throughput sequencing identifies aetiology-dependent differences in ductular reaction in human chronic liver disease [0.03%]
高通量测序鉴定人慢性肝病管腔反应的病因依赖性差异
Olivier Govaere,Simon Cockell,Matthias Van Haele et al.
Olivier Govaere et al.
Ductular reaction (DR) represents the activation of hepatic progenitor cells (HPCs) and has been associated with features of advanced chronic liver disease; yet it is not clear whether these cells contribute to disease progression and how t...
Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine [0.03%]
遗传易感性结直肠癌：综合征、基因、遗传变异分类及其对精准医学的影响
Laura Valle,Eduardo Vilar,Sean V Tavtigian et al.
Laura Valle et al.
This article reviews genes and syndromes associated with predisposition to colorectal cancer (CRC), with an overview of gene variant classification. We include updates on the application of preventive and therapeutic measures, focusing on t...
Neutrophil trafficking to lymphoid tissues: physiological and pathological implications [0.03%]
中性粒细胞向淋巴组织迁移：生理与病理意义
Mathieu-Benoit Voisin,Sussan Nourshargh
Mathieu-Benoit Voisin
Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that neutrophils are short-lived prototypical innate immune cells solely involved in acute re...
Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis [0.03%]
近期关于基质金属蛋白酶在肿瘤侵袭和转移中作用研究的进展
Guy A Conlon,Graeme I Murray
Guy A Conlon
This review aims to provide an overview of recent developments regarding the roles of MMPs in tumour invasion and metastasis. Much of the mortality burden belonging to cancer relates to its ability to invade adjacent tissue and form metasta...
Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease [0.03%]
纤维芽细胞生长因子-21对高血压性心脏病的抗纤维化保护作用
Gemma Ferrer-Curriu,Ibon Redondo-Angulo,Mariona Guitart-Mampel et al.
Gemma Ferrer-Curriu et al.
FGF21 is an endocrine factor that contributes to multiple pathophysiological processes, mainly via its action as a metabolic regulator and cardioprotective agent. Recent studies have shown increased circulating FGF21 levels in hypertensive ...
Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma [0.03%]
人胰腺导管腺癌中癌症相关成纤维细胞的异质性分析
Cindy Neuzillet,Annemilaï Tijeras-Raballand,Chanthirika Ragulan et al.
Cindy Neuzillet et al.
Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus anti-tumoural) in PDAC...
Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential [0.03%]
中性粒细胞在急性肺部炎症的发生和消退中的作用：理解其生物学功能及治疗潜能
Philippe Md Potey,Adriano G Rossi,Christopher D Lucas et al.
Philippe Md Potey et al.
Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of precipitating conditions. Despite decades of intensive research and clinical trials there remain no therapies in routine clinical practice that targe...